Association of Obstructive Sleep Apnea Syndrome with Leptin Receptor Gene Q223R and K109R Single Nucleotide Polymorphisms in the Iranian Kurdish Population

• Published in: Genetic testing and molecular biomarkers Vol. 29; no. 7; p. 185
• Main Authors: Alizadeh Severi, Ali, Rasouli, Sharareh, Abdolsamadi, Mohammad, Safari, Fatemeh, Salari, Farhad, Mahdieh, Nejat, Veisi, Kamal, Akbari, Bahman
• Format: Journal Article
• Language: English
• Published: United States 01.07.2025
• Subjects: Adult; Alleles; Case-Control Studies; Female; Gene Frequency - genetics; Genetic Predisposition to Disease; Genotype; Humans; Iran; Male; Middle Aged; Obesity - genetics; Polymorphism, Single Nucleotide - genetics; Polysomnography; Receptors, Leptin - genetics; Receptors, Leptin - metabolism; Sleep Apnea, Obstructive - genetics; Iran; LEPR; OSAS; PCR-RFLP; SNP

Obstructive sleep apnea syndrome (OSAS) is a kind of sleep disturbance in which breathing is reduced or stopped for a short time and, if left untreated, can lead to long-term dangerous complications such as heart attack and obesity. Previous studies have shown that leptin receptor (LEPR) gene polymo...