Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo

• Published in: Biochemical and biophysical research communications Vol. 315; no. 2; pp. 502 - 508
• Main Authors: Schallreuter, Karin U, Elwary, Souna M A, Gibbons, Nicholas C J, Rokos, Hartmut, Wood, John M
• Format: Journal Article
• Language: English
• Published: United States 05.03.2004
• Subjects: Acetylcholinesterase - chemistry; Acetylcholinesterase - metabolism; Binding Sites; Biopsy; Catalase - biosynthesis; Dihydropteridine Reductase - metabolism; Dose-Response Relationship, Drug; Epidermis - enzymology; Epidermis - metabolism; Humans; Hydro-Lyases - metabolism; Hydrogen Peroxide - chemistry; Hydrogen Peroxide - pharmacology; Immunohistochemistry; Kinetics; Microscopy, Fluorescence; Models, Molecular; Oxidative Stress; Oxygen - metabolism; Skin - metabolism; Spectrometry, Fluorescence; Tryptophan - chemistry; Up-Regulation; Vitiligo - metabolism; Vitiligo - pathology

Previously it has been demonstrated that the human epidermis synthesises and degrades acetylcholine and expresses both muscarinic and nicotinic receptors. These cholinergic systems have been implicated in the development of the epidermal calcium gradient and differentiation in normal healthy skin. I...