Association Analysis of Four Single Nucleotide Polymorpism(SNP) Variants of the Toll-Like Receptor 4 (TLR4) Gene and Gout in Males of Bai Minority from Dali Prefecture, Yunnan Province, Southwest China

• Published in: Genetic testing and molecular biomarkers Vol. 29; no. 7; p. 193
• Main Authors: Huang, Wenbing, Tang, Ximin, Yang, Yongqin, He, Jintao, Zhao, Dan, Li, Jinsong, Lin, Yaru, Li, Zhengliang, Li, Jiangyan, Xiong, Wei
• Format: Journal Article
• Language: English
• Published: United States 01.07.2025
• Subjects: Adult; Aged; Alleles; Case-Control Studies; China; East Asian People - genetics; Gene Frequency - genetics; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Genotype; Gout - genetics; Humans; Hyperuricemia - genetics; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - metabolism; Uric Acid; China; hyperuricemia (HUA); Bai minority; toll-like receptor 4 (TLR4); primary gout; single nucleotide polymorphism (SNP)

Gout is the most common arthritis, and it is associated with monosodium urate (MSU) crystal deposits in articulations, kidney, and soft tissue. The MSU crystal deposit initiates an inflammatory response, mediated by inflammasome, with the release of interleukin-1beta. Toll-like receptor 4 ( ) is inv...