Enhancement of aqueous stability and fluorescence brightness of indocyanine green using small calix[4]arene micelles for near-infrared fluorescence imaging
Indocyanine green (ICG) is the only near-infrared (NIR) fluorescent dye which is approved for medical applications. However, ICG has several drawbacks such as aqueous instability, photodegradation, and low fluorescence quantum yield (2.5% in water), which lead to the limitation on the use of ICG for...
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Published in | MedChemComm Vol. 7; no. 4; pp. 623 - 631 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.01.2016
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Abstract | Indocyanine green (ICG) is the only near-infrared (NIR) fluorescent dye which is approved for medical applications. However, ICG has several drawbacks such as aqueous instability, photodegradation, and low fluorescence quantum yield (2.5% in water), which lead to the limitation on the use of ICG for
in vitro
and
in vivo
NIR fluorescence imaging. Free ICG rapidly aggregates in physiological buffer solutions, and its fluorescence diminishes within several days. The objective of this work is to provide an easy method for the enhancement of the stability and fluorescence brightness of ICG in aqueous solutions for NIR fluorescence imaging. Herein, we report that the incorporation of ICG into small calix[4]arene (
S4-6
) micelles (<5 nm in diameter) significantly improves the aqueous stability and fluorescence brightness of ICG. The fluorescence quantum yields of ICG-calix[4]arene micelles are increased up to ∼6% in aqueous solutions. Using the ICG-calix[4]arene micelles, we achieved non-invasive NIR fluorescence imaging of the liver and lymph system in mice. Furthermore, we achieved NIR fluorescence imaging of nude mice bearing human breast tumors using an ICG conjugated antibody which is incorporated into the calix[4]arene micelles. Preparation of the calix[4]arene micelles including ICG is very easy and the micelle system does not show significant cytotoxicity. The ICG-calix[4]arene micelle system acts as a highly stable and bright probe for
in vitro
and
in vivo
NIR fluorescence imaging. |
---|---|
AbstractList | Indocyanine green (ICG) is the only near-infrared (NIR) fluorescent dye which is approved for medical applications. However, ICG has several drawbacks such as aqueous instability, photodegradation, and low fluorescence quantum yield (2.5% in water), which lead to the limitation on the use of ICG for
in vitro
and
in vivo
NIR fluorescence imaging. Free ICG rapidly aggregates in physiological buffer solutions, and its fluorescence diminishes within several days. The objective of this work is to provide an easy method for the enhancement of the stability and fluorescence brightness of ICG in aqueous solutions for NIR fluorescence imaging. Herein, we report that the incorporation of ICG into small calix[4]arene (
S4-6
) micelles (<5 nm in diameter) significantly improves the aqueous stability and fluorescence brightness of ICG. The fluorescence quantum yields of ICG-calix[4]arene micelles are increased up to ∼6% in aqueous solutions. Using the ICG-calix[4]arene micelles, we achieved non-invasive NIR fluorescence imaging of the liver and lymph system in mice. Furthermore, we achieved NIR fluorescence imaging of nude mice bearing human breast tumors using an ICG conjugated antibody which is incorporated into the calix[4]arene micelles. Preparation of the calix[4]arene micelles including ICG is very easy and the micelle system does not show significant cytotoxicity. The ICG-calix[4]arene micelle system acts as a highly stable and bright probe for
in vitro
and
in vivo
NIR fluorescence imaging. |
Author | Muranaka, Yoshinori Tsuboi, Setsuko Imamura, Yukio Sakata, Takao Yasuda, Hidehiro Komatsuzaki, Akihito Jin, Takashi |
Author_xml | – sequence: 1 givenname: Takashi surname: Jin fullname: Jin, Takashi organization: Laboratory for Nano-Bio Probes, Quantitative Biology Center (QBiC), Riken, Suita, Japan, Immunology Frontier Research Center (IFReC) – sequence: 2 givenname: Setsuko surname: Tsuboi fullname: Tsuboi, Setsuko organization: Laboratory for Nano-Bio Probes, Quantitative Biology Center (QBiC), Riken, Suita, Japan – sequence: 3 givenname: Akihito surname: Komatsuzaki fullname: Komatsuzaki, Akihito organization: Laboratory for Nano-Bio Probes, Quantitative Biology Center (QBiC), Riken, Suita, Japan – sequence: 4 givenname: Yukio surname: Imamura fullname: Imamura, Yukio organization: Laboratory for Nano-Bio Probes, Quantitative Biology Center (QBiC), Riken, Suita, Japan – sequence: 5 givenname: Yoshinori surname: Muranaka fullname: Muranaka, Yoshinori organization: Research Center for Ultra-High Voltage Electron Microscopy, Osaka University, Ibaraki, Japan – sequence: 6 givenname: Takao surname: Sakata fullname: Sakata, Takao organization: Research Center for Ultra-High Voltage Electron Microscopy, Osaka University, Ibaraki, Japan – sequence: 7 givenname: Hidehiro surname: Yasuda fullname: Yasuda, Hidehiro organization: Research Center for Ultra-High Voltage Electron Microscopy, Osaka University, Ibaraki, Japan |
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Cites_doi | 10.1038/nbt.1918 10.1039/C4CC09689D 10.1016/j.cbpa.2003.08.007 10.1039/C4RA09735A 10.1016/j.biomaterials.2013.12.096 10.1111/cas.12553 10.1021/ml400533y 10.1038/sj.bjc.6690114 10.1021/mp8001649 10.1007/s00432-014-1611-9 10.1006/jcis.1996.4648 10.1016/j.cbpa.2015.06.005 10.3109/08982104.2013.801488 10.1039/c1md00171j 10.1002/jps.10470 10.1021/bc400050k 10.1016/j.jphotobiol.2004.01.002 10.1016/j.bmc.2013.12.026 10.1158/0008-5472.CAN-10-0271 10.1158/0008-5472.CAN-08-3116 10.1117/1.2834296 10.1038/nnano.2009.326 10.1016/j.biomaterials.2013.08.022 10.1038/86684 10.1016/j.ijpharm.2005.11.003 10.3390/s8053082 10.1016/j.bmcl.2012.10.044 10.1039/C4LC01032A 10.1021/la0001833 10.1186/bcr3167 10.1117/1.3593386 10.1038/nbt1340 10.1117/1.JBO.18.12.126014 10.1038/nbt920 10.1016/j.pdpdt.2014.02.001 10.1016/j.molmed.2010.08.006 10.1039/C4PY00495G 10.1002/lsm.22269 10.1021/bc500312w 10.1021/mp200381c 10.1021/bc900311h 10.1016/j.nano.2011.01.001 10.1016/S0039-6257(00)00123-5 10.1021/bi500021j 10.1167/iovs.13-13617 10.1007/s11095-010-0190-y 10.1016/j.biomaterials.2014.10.014 10.1039/b506608e 10.1126/science.2999974 10.1016/S1011-1344(98)00216-4 10.1021/ja00269a045 10.1039/c3cc44000a 10.1016/j.biomaterials.2012.04.044 10.1016/S0168-8278(99)80227-X 10.1021/nn5062386 10.1136/bjo.2007.129395 10.1117/1.JBO.19.1.016019 10.2217/nnm.14.118 |
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References | Nakane (C5MD00580A-(cit10)/*[position()=1]) 2013; 49 Beziere (C5MD00580A-(cit32)/*[position()=1]) 2015; 37 Abuin (C5MD00580A-(cit53)/*[position()=1]) 1997; 186 Coussens (C5MD00580A-(cit62)/*[position()=1]) 1985; 230 Yang (C5MD00580A-(cit43)/*[position()=1]) 2013; 34 Shcherbakova (C5MD00580A-(cit8)/*[position()=1]) 2015; 27 Kurebayshi (C5MD00580A-(cit63)/*[position()=1]) 1998; 79 Shinkai (C5MD00580A-(cit51)/*[position()=1]) 1986; 108 Caesar (C5MD00580A-(cit11)/*[position()=1]) 1961; 21 Chen (C5MD00580A-(cit48)/*[position()=1]) 2014; 5 Jin (C5MD00580A-(cit52)/*[position()=1]) 2005 Shemesh (C5MD00580A-(cit28)/*[position()=1]) 2014; 11 Deng (C5MD00580A-(cit42)/*[position()=1]) 2012; 13 Sano (C5MD00580A-(cit59)/*[position()=1]) 2013; 24 Suganami (C5MD00580A-(cit22)/*[position()=1]) 2012; 22 Griffiths (C5MD00580A-(cit54)/*[position()=1]) 2000; 16 Yan (C5MD00580A-(cit49)/*[position()=1]) 2015; 10 Choi (C5MD00580A-(cit50)/*[position()=1]) 2007; 25 Proulx (C5MD00580A-(cit19)/*[position()=1]) 2010; 70 Zanganeh (C5MD00580A-(cit25)/*[position()=1]) 2013; 18 Toyota (C5MD00580A-(cit26)/*[position()=1]) 2014; 22 Smith (C5MD00580A-(cit2)/*[position()=1]) 2009; 4 Jiguet-Jiglaire (C5MD00580A-(cit7)/*[position()=1]) 2014; 19 Desmettre (C5MD00580A-(cit12)/*[position()=1]) 2000; 45 Yuan (C5MD00580A-(cit30)/*[position()=1]) 2015; 15 Kim (C5MD00580A-(cit41)/*[position()=1]) 2012; 9 Sheng (C5MD00580A-(cit37)/*[position()=1]) 2014; 12 Kim (C5MD00580A-(cit9)/*[position()=1]) 2004; 22 Dhaliwal (C5MD00580A-(cit5)/*[position()=1]) 2011; 2 Song (C5MD00580A-(cit31)/*[position()=1]) 2015; 5 Saxena (C5MD00580A-(cit33)/*[position()=1]) 2004; 74 Sano (C5MD00580A-(cit58)/*[position()=1]) 2012; 14 Flionov (C5MD00580A-(cit6)/*[position()=1]) 2011; 29 Kraft (C5MD00580A-(cit27)/*[position()=1]) 2014; 53 Ogawa (C5MD00580A-(cit57)/*[position()=1]) 2009; 69 Zhou (C5MD00580A-(cit61)/*[position()=1]) 2014; 25 Zheng (C5MD00580A-(cit35)/*[position()=1]) 2012; 33 Sandanaraji (C5MD00580A-(cit20)/*[position()=1]) 2010; 21 Jeong (C5MD00580A-(cit24)/*[position()=1]) 2013; 23 Yu (C5MD00580A-(cit46)/*[position()=1]) 2014; 35 Weissleder (C5MD00580A-(cit1)/*[position()=1]) 2001; 19 Portnoy (C5MD00580A-(cit21)/*[position()=1]) 2011; 7 Bahmani (C5MD00580A-(cit36)/*[position()=1]) 2014; 46 Kim (C5MD00580A-(cit40)/*[position()=1]) 2010; 27 Tsujimoto (C5MD00580A-(cit13)/*[position()=1]) 2014; 105 Hua (C5MD00580A-(cit23)/*[position()=1]) 2012; 18 Wu (C5MD00580A-(cit44)/*[position()=1]) 2013; 14 Gerega (C5MD00580A-(cit55)/*[position()=1]) 2011; 16 Watanabe (C5MD00580A-(cit60)/*[position()=1]) 2014; 5 Kirchherr (C5MD00580A-(cit16)/*[position()=1]) 2009; 6 Frangioni (C5MD00580A-(cit3)/*[position()=1]) 2003; 7 Saxena (C5MD00580A-(cit18)/*[position()=1]) 2006; 308 Kirchherr (C5MD00580A-(cit39)/*[position()=1]) 2009; 6 Meyer (C5MD00580A-(cit45)/*[position()=1]) 2014; 55 Koura (C5MD00580A-(cit56)/*[position()=1]) 1999; 31 Holzer (C5MD00580A-(cit17)/*[position()=1]) 1998; 47 Cardillo (C5MD00580A-(cit15)/*[position()=1]) 2008; 92 Amiot (C5MD00580A-(cit4)/*[position()=1]) 2008; 8 He (C5MD00580A-(cit34)/*[position()=1]) 2010; 16 Saxena (C5MD00580A-(cit14)/*[position()=1]) 2003; 92 Rodriguez (C5MD00580A-(cit38)/*[position()=1]) 2008; 13 Zhu (C5MD00580A-(cit29)/*[position()=1]) 2015; 15 Tu (C5MD00580A-(cit47)/*[position()=1]) 2014; 140 |
References_xml | – volume: 29 start-page: 757 year: 2011 ident: C5MD00580A-(cit6)/*[position()=1] publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1918 contributor: fullname: Flionov – volume: 15 start-page: 3340 year: 2015 ident: C5MD00580A-(cit30)/*[position()=1] publication-title: Chem. Commun. doi: 10.1039/C4CC09689D contributor: fullname: Yuan – volume: 7 start-page: 626 year: 2003 ident: C5MD00580A-(cit3)/*[position()=1] publication-title: Curr. Opin. Chem. Biol. doi: 10.1016/j.cbpa.2003.08.007 contributor: fullname: Frangioni – volume: 5 start-page: 3807 year: 2015 ident: C5MD00580A-(cit31)/*[position()=1] publication-title: RSC Adv. doi: 10.1039/C4RA09735A contributor: fullname: Song – volume: 35 start-page: 3467 year: 2014 ident: C5MD00580A-(cit46)/*[position()=1] publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.12.096 contributor: fullname: Yu – volume: 105 start-page: 1626 year: 2014 ident: C5MD00580A-(cit13)/*[position()=1] publication-title: Cancer Sci. doi: 10.1111/cas.12553 contributor: fullname: Tsujimoto – volume: 5 start-page: 411 year: 2014 ident: C5MD00580A-(cit60)/*[position()=1] publication-title: ACS Med. Chem. Lett. doi: 10.1021/ml400533y contributor: fullname: Watanabe – volume: 79 start-page: 707 year: 1998 ident: C5MD00580A-(cit63)/*[position()=1] publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6690114 contributor: fullname: Kurebayshi – volume: 6 start-page: 480 year: 2009 ident: C5MD00580A-(cit16)/*[position()=1] publication-title: Mol. Pharmaceutics doi: 10.1021/mp8001649 contributor: fullname: Kirchherr – volume: 140 start-page: 623 year: 2014 ident: C5MD00580A-(cit47)/*[position()=1] publication-title: J. Cancer Res. Clin. Oncol. doi: 10.1007/s00432-014-1611-9 contributor: fullname: Tu – volume: 186 start-page: 332 year: 1997 ident: C5MD00580A-(cit53)/*[position()=1] publication-title: J. Colloid Interface Sci. doi: 10.1006/jcis.1996.4648 contributor: fullname: Abuin – volume: 18 start-page: 1045 year: 2012 ident: C5MD00580A-(cit23)/*[position()=1] publication-title: Mol. Vision contributor: fullname: Hua – volume: 27 start-page: 52 year: 2015 ident: C5MD00580A-(cit8)/*[position()=1] publication-title: Curr. Opin. Chem. Biol. doi: 10.1016/j.cbpa.2015.06.005 contributor: fullname: Shcherbakova – volume: 23 start-page: 291 year: 2013 ident: C5MD00580A-(cit24)/*[position()=1] publication-title: J. Liposome Res. doi: 10.3109/08982104.2013.801488 contributor: fullname: Jeong – volume: 13 start-page: 3795 year: 2012 ident: C5MD00580A-(cit42)/*[position()=1] publication-title: Macromolecules contributor: fullname: Deng – volume: 2 start-page: 1050 year: 2011 ident: C5MD00580A-(cit5)/*[position()=1] publication-title: Med. Chem. Commun. doi: 10.1039/c1md00171j contributor: fullname: Dhaliwal – volume: 92 start-page: 2090 year: 2003 ident: C5MD00580A-(cit14)/*[position()=1] publication-title: J. Pharm. Sci. doi: 10.1002/jps.10470 contributor: fullname: Saxena – volume: 24 start-page: 811 year: 2013 ident: C5MD00580A-(cit59)/*[position()=1] publication-title: Bioconjugate Chem. doi: 10.1021/bc400050k contributor: fullname: Sano – volume: 74 start-page: 29 year: 2004 ident: C5MD00580A-(cit33)/*[position()=1] publication-title: J. Photochem. Photobiol., B doi: 10.1016/j.jphotobiol.2004.01.002 contributor: fullname: Saxena – volume: 22 start-page: 721 year: 2014 ident: C5MD00580A-(cit26)/*[position()=1] publication-title: Bioorg. Med. Chem. doi: 10.1016/j.bmc.2013.12.026 contributor: fullname: Toyota – volume: 70 start-page: 7053 year: 2010 ident: C5MD00580A-(cit19)/*[position()=1] publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-10-0271 contributor: fullname: Proulx – volume: 69 start-page: 1268 year: 2009 ident: C5MD00580A-(cit57)/*[position()=1] publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-08-3116 contributor: fullname: Ogawa – volume: 13 start-page: 014025 year: 2008 ident: C5MD00580A-(cit38)/*[position()=1] publication-title: J. Biomed. Opt. doi: 10.1117/1.2834296 contributor: fullname: Rodriguez – volume: 4 start-page: 710 year: 2009 ident: C5MD00580A-(cit2)/*[position()=1] publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2009.326 contributor: fullname: Smith – volume: 34 start-page: 9124 year: 2013 ident: C5MD00580A-(cit43)/*[position()=1] publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.08.022 contributor: fullname: Yang – volume: 19 start-page: 316 year: 2001 ident: C5MD00580A-(cit1)/*[position()=1] publication-title: Nat. Biotechnol. doi: 10.1038/86684 contributor: fullname: Weissleder – volume: 14 start-page: 3027 year: 2013 ident: C5MD00580A-(cit44)/*[position()=1] publication-title: Macromolecules contributor: fullname: Wu – volume: 6 start-page: 480 year: 2009 ident: C5MD00580A-(cit39)/*[position()=1] publication-title: Mol. Pharmaceutics doi: 10.1021/mp8001649 contributor: fullname: Kirchherr – volume: 308 start-page: 200 year: 2006 ident: C5MD00580A-(cit18)/*[position()=1] publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2005.11.003 contributor: fullname: Saxena – volume: 8 start-page: 3038 year: 2008 ident: C5MD00580A-(cit4)/*[position()=1] publication-title: Sensors doi: 10.3390/s8053082 contributor: fullname: Amiot – volume: 22 start-page: 7481 year: 2012 ident: C5MD00580A-(cit22)/*[position()=1] publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2012.10.044 contributor: fullname: Suganami – volume: 15 start-page: 646 year: 2015 ident: C5MD00580A-(cit29)/*[position()=1] publication-title: Lab Chip doi: 10.1039/C4LC01032A contributor: fullname: Zhu – volume: 16 start-page: 8248 year: 2000 ident: C5MD00580A-(cit54)/*[position()=1] publication-title: Langmuir doi: 10.1021/la0001833 contributor: fullname: Griffiths – volume: 21 start-page: 43 year: 1961 ident: C5MD00580A-(cit11)/*[position()=1] publication-title: Clin. Sci. contributor: fullname: Caesar – volume: 14 start-page: R16 year: 2012 ident: C5MD00580A-(cit58)/*[position()=1] publication-title: Breast Cancer Res. doi: 10.1186/bcr3167 contributor: fullname: Sano – volume: 16 start-page: 067010 year: 2011 ident: C5MD00580A-(cit55)/*[position()=1] publication-title: J. Biomed. Opt. doi: 10.1117/1.3593386 contributor: fullname: Gerega – volume: 25 start-page: 1165 year: 2007 ident: C5MD00580A-(cit50)/*[position()=1] publication-title: Nat. Biotechnol. doi: 10.1038/nbt1340 contributor: fullname: Choi – volume: 18 start-page: 126014 year: 2013 ident: C5MD00580A-(cit25)/*[position()=1] publication-title: J. Biomed. Opt. doi: 10.1117/1.JBO.18.12.126014 contributor: fullname: Zanganeh – volume: 22 start-page: 93 year: 2004 ident: C5MD00580A-(cit9)/*[position()=1] publication-title: Nat. Biotechnol. doi: 10.1038/nbt920 contributor: fullname: Kim – volume: 11 start-page: 193 year: 2014 ident: C5MD00580A-(cit28)/*[position()=1] publication-title: Photodiagn. Photodyn. Ther. doi: 10.1016/j.pdpdt.2014.02.001 contributor: fullname: Shemesh – volume: 16 start-page: 574 year: 2010 ident: C5MD00580A-(cit34)/*[position()=1] publication-title: Trends Mol. Med. doi: 10.1016/j.molmed.2010.08.006 contributor: fullname: He – volume: 5 start-page: 4734 year: 2014 ident: C5MD00580A-(cit48)/*[position()=1] publication-title: Polym. Chem. doi: 10.1039/C4PY00495G contributor: fullname: Chen – volume: 46 start-page: 582 year: 2014 ident: C5MD00580A-(cit36)/*[position()=1] publication-title: Lasers Surg. Med. doi: 10.1002/lsm.22269 contributor: fullname: Bahmani – volume: 25 start-page: 1801 year: 2014 ident: C5MD00580A-(cit61)/*[position()=1] publication-title: Bioconjugate Chem. doi: 10.1021/bc500312w contributor: fullname: Zhou – volume: 9 start-page: 135 year: 2012 ident: C5MD00580A-(cit41)/*[position()=1] publication-title: Mol. Pharmaceutics doi: 10.1021/mp200381c contributor: fullname: Kim – volume: 21 start-page: 93 year: 2010 ident: C5MD00580A-(cit20)/*[position()=1] publication-title: Bioconjugate Chem. doi: 10.1021/bc900311h contributor: fullname: Sandanaraji – volume: 7 start-page: 480 year: 2011 ident: C5MD00580A-(cit21)/*[position()=1] publication-title: Nanomedicine doi: 10.1016/j.nano.2011.01.001 contributor: fullname: Portnoy – volume: 45 start-page: 15 year: 2000 ident: C5MD00580A-(cit12)/*[position()=1] publication-title: Surv. Ophthalmol. doi: 10.1016/S0039-6257(00)00123-5 contributor: fullname: Desmettre – volume: 53 start-page: 1275 year: 2014 ident: C5MD00580A-(cit27)/*[position()=1] publication-title: Biochemistry doi: 10.1021/bi500021j contributor: fullname: Kraft – volume: 55 start-page: 6204 year: 2014 ident: C5MD00580A-(cit45)/*[position()=1] publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.13-13617 contributor: fullname: Meyer – volume: 27 start-page: 1900 year: 2010 ident: C5MD00580A-(cit40)/*[position()=1] publication-title: Pharm. Res. doi: 10.1007/s11095-010-0190-y contributor: fullname: Kim – volume: 37 start-page: 415 year: 2015 ident: C5MD00580A-(cit32)/*[position()=1] publication-title: Biomaterials doi: 10.1016/j.biomaterials.2014.10.014 contributor: fullname: Beziere – start-page: 4300 year: 2005 ident: C5MD00580A-(cit52)/*[position()=1] publication-title: Chem. Commun. doi: 10.1039/b506608e contributor: fullname: Jin – volume: 230 start-page: 1132 year: 1985 ident: C5MD00580A-(cit62)/*[position()=1] publication-title: Science doi: 10.1126/science.2999974 contributor: fullname: Coussens – volume: 47 start-page: 155 year: 1998 ident: C5MD00580A-(cit17)/*[position()=1] publication-title: J. Photochem. Photobiol., B doi: 10.1016/S1011-1344(98)00216-4 contributor: fullname: Holzer – volume: 108 start-page: 2409 year: 1986 ident: C5MD00580A-(cit51)/*[position()=1] publication-title: J. Am. Chem. Soc. doi: 10.1021/ja00269a045 contributor: fullname: Shinkai – volume: 49 start-page: 7584 year: 2013 ident: C5MD00580A-(cit10)/*[position()=1] publication-title: Chem. Commun. doi: 10.1039/c3cc44000a contributor: fullname: Nakane – volume: 33 start-page: 5603 year: 2012 ident: C5MD00580A-(cit35)/*[position()=1] publication-title: Biomaterials doi: 10.1016/j.biomaterials.2012.04.044 contributor: fullname: Zheng – volume: 31 start-page: 293 year: 1999 ident: C5MD00580A-(cit56)/*[position()=1] publication-title: J. Hepatol. doi: 10.1016/S0168-8278(99)80227-X contributor: fullname: Koura – volume: 12 start-page: 12310 year: 2014 ident: C5MD00580A-(cit37)/*[position()=1] publication-title: ACS Nano doi: 10.1021/nn5062386 contributor: fullname: Sheng – volume: 92 start-page: 276 year: 2008 ident: C5MD00580A-(cit15)/*[position()=1] publication-title: Br. J. Ophthalmol. doi: 10.1136/bjo.2007.129395 contributor: fullname: Cardillo – volume: 19 start-page: 016019 year: 2014 ident: C5MD00580A-(cit7)/*[position()=1] publication-title: J. Biomed. Opt. doi: 10.1117/1.JBO.19.1.016019 contributor: fullname: Jiguet-Jiglaire – volume: 10 start-page: 361 year: 2015 ident: C5MD00580A-(cit49)/*[position()=1] publication-title: Nanomedicine doi: 10.2217/nnm.14.118 contributor: fullname: Yan |
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Snippet | Indocyanine green (ICG) is the only near-infrared (NIR) fluorescent dye which is approved for medical applications. However, ICG has several drawbacks such as... |
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Title | Enhancement of aqueous stability and fluorescence brightness of indocyanine green using small calix[4]arene micelles for near-infrared fluorescence imaging |
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