Azo-Schiff base derivatives of transition metal complexes as antimicrobial agents
[Display omitted] •Average global HALE is vulnerable to morbidities mediated by (Antimicrobial Resistant) microbes with their abrupt evolutionary course.•Pharmaceutic potentiality of Azo & Azomethine moieties in Azo-Schiff Base Ligands have been subject of antimicrobial investigations.•Metalatio...
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| Published in | Coordination chemistry reviews Vol. 447; p. 214128 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
15.11.2021
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| Subjects | |
| Online Access | Get full text |
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| Abstract | [Display omitted]
•Average global HALE is vulnerable to morbidities mediated by (Antimicrobial Resistant) microbes with their abrupt evolutionary course.•Pharmaceutic potentiality of Azo & Azomethine moieties in Azo-Schiff Base Ligands have been subject of antimicrobial investigations.•Metalation of ASBLs drastically reinforce the antibacterial and antifungal face of parent compounds.•Well-founded approach to design and characterisation of metal derivatives of ASBLs have been extended over the last two decennia.
AMR (Antimicrobial-resistant) pathogens like MRSA (Methicillin-Resistant Staphylococcus aureus) have become prodigious peril to human health in the past couple of years with the failure of various antifungals and antibiotics in treating mild to chronic mycoses and septicemia. In the grave concern for the rising contagions, Azo-Schiff Bases with dual functionality and far-ranging pharmacological potential has been considered an excellent target for antimicrobial investigations. A diversity of homocyclic and heterocyclic organic precursors has been utilized for submitting novelty in the Azo-Schiff Base Ligands (ASBLs). In addition, the d-block transition metal chelates of ASBLs with infinitely diverse features have also been synthesized and characterized exploiting the classical and advanced analytical techniques. These resourceful coordination compounds owing to their characteristic polydentate ligands with multiple coordination sites, the geometry of complexes, and redox nature of metal centres are bestowed with the structural tunability to reinvigorate their potential applications. A detailed literature survey divulged that no compendious review has yet been published on ASBL-metal derivatives. Therefore, the present study encompasses the research undertaken during the last two decennia for the development and in vitro antimicrobial screening of these prospective drug agents. |
|---|---|
| AbstractList | [Display omitted]
•Average global HALE is vulnerable to morbidities mediated by (Antimicrobial Resistant) microbes with their abrupt evolutionary course.•Pharmaceutic potentiality of Azo & Azomethine moieties in Azo-Schiff Base Ligands have been subject of antimicrobial investigations.•Metalation of ASBLs drastically reinforce the antibacterial and antifungal face of parent compounds.•Well-founded approach to design and characterisation of metal derivatives of ASBLs have been extended over the last two decennia.
AMR (Antimicrobial-resistant) pathogens like MRSA (Methicillin-Resistant Staphylococcus aureus) have become prodigious peril to human health in the past couple of years with the failure of various antifungals and antibiotics in treating mild to chronic mycoses and septicemia. In the grave concern for the rising contagions, Azo-Schiff Bases with dual functionality and far-ranging pharmacological potential has been considered an excellent target for antimicrobial investigations. A diversity of homocyclic and heterocyclic organic precursors has been utilized for submitting novelty in the Azo-Schiff Base Ligands (ASBLs). In addition, the d-block transition metal chelates of ASBLs with infinitely diverse features have also been synthesized and characterized exploiting the classical and advanced analytical techniques. These resourceful coordination compounds owing to their characteristic polydentate ligands with multiple coordination sites, the geometry of complexes, and redox nature of metal centres are bestowed with the structural tunability to reinvigorate their potential applications. A detailed literature survey divulged that no compendious review has yet been published on ASBL-metal derivatives. Therefore, the present study encompasses the research undertaken during the last two decennia for the development and in vitro antimicrobial screening of these prospective drug agents. |
| ArticleNumber | 214128 |
| Author | Pervaiz, Muhammad Zuber, Muhammad Ashraf, Adnan Saeed, Zohaib Younas, Umer Sadiq, Sahar Sadiq, Amber Adnan, Ahmad |
| Author_xml | – sequence: 1 givenname: Muhammad surname: Pervaiz fullname: Pervaiz, Muhammad email: mpbhatti786@gmail.com organization: Department of Chemistry, Government College University, Lahore, Pakistan – sequence: 2 givenname: Sahar surname: Sadiq fullname: Sadiq, Sahar organization: Department of Chemistry, The University of Lahore, Lahore, Pakistan – sequence: 3 givenname: Amber surname: Sadiq fullname: Sadiq, Amber organization: Department of Chemistry, The University of Lahore, Lahore, Pakistan – sequence: 4 givenname: Umer surname: Younas fullname: Younas, Umer email: umer.younas@chem.uol.edu.pk organization: Department of Chemistry, The University of Lahore, Lahore, Pakistan – sequence: 5 givenname: Adnan orcidid: 0000-0002-6396-5059 surname: Ashraf fullname: Ashraf, Adnan organization: Department of Chemistry, The University of Lahore, Lahore, Pakistan – sequence: 6 givenname: Zohaib surname: Saeed fullname: Saeed, Zohaib organization: Department of Chemistry, Government College University, Lahore, Pakistan – sequence: 7 givenname: Muhammad surname: Zuber fullname: Zuber, Muhammad organization: Department of Chemistry, The University of Lahore, Lahore, Pakistan – sequence: 8 givenname: Ahmad surname: Adnan fullname: Adnan, Ahmad email: ahmadadnan@gcu.edu.pk organization: Department of Chemistry, Government College University, Lahore, Pakistan |
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•Average global HALE is vulnerable to morbidities mediated by (Antimicrobial Resistant) microbes with their abrupt evolutionary... |
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| SubjectTerms | Antimicrobial-resistant pathogens Azo-Schiff derivatives Growth inhibition Lipophilicity Metal chelates |
| Title | Azo-Schiff base derivatives of transition metal complexes as antimicrobial agents |
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