Oxygen-Free Csp3-H Oxidation of Pyridin-2-yl-methanes to Pyridin-2-yl-methanones with Water by Copper Catalysis

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 22; p. 7587
• Main Authors: Zeng, Ming, Chen, Jia-Le, Luo, Xue, Zou, Yan-Jiao, Liu, Zhao-Ning, Dai, Jun, Jiang, Deng-Zhao, Li, Jin-Jing
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 14.11.2023
• Subjects: Antifungal agents; By products; Catalysis; Chromatography; Copper; copper catalysis; Csp3-H oxidation; mechanism study; Oxidation; pyridin-2-yl-methanones; water

Aromatic ketones are important pharmaceutical intermediates, especially the pyridin-2-yl-methanone motifs. Thus, synthetic methods for these compounds have gained extensive attention in the last few years. Transition metals catalyze the oxidation of Csp3-H for the synthesis of aromatic ketones, whic...