A natural product-derived nanozyme regulator induced chemo-ferroptosis dual therapy in remodeling of the tumor immune microenvironment of hepatocellular carcinoma

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Vol. 482; p. 148976
• Main Authors: Lai, Chun-Mei, Xu, Jia, Zhang, Bing-Chen, He, Shao-Hua, Shao, Jing-Wei
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.02.2024
• Subjects: Ferroptosis; Hepatocellular carcinoma; Nanozyme; Tumor immune microenvironment; Hepatocellular carcinoma; Nanozyme; Ferroptosis; Tumor immune microenvironment
• ISSN: 1385-8947; 1873-3212
• DOI: 10.1016/j.cej.2024.148976

•Ursolic acid-based carbon dots (CDs) nanozyme synthesized for the first time.•UCDs exerted glutathione (GSH) oxidase-like activity by catalyzing GSH to oxidized glutathione.•CDs induced HepG2 cell ferroptosis by promoting an imbalanced redox reaction.•UCDs initiated ferroptosis-dependent immune cel...