Clinical trial design, nasal allergen challenge models, and considerations of relevance to pediatrics, nasal polyposis, and different classes of medication

• Published in: Journal of allergy and clinical immunology Vol. 115; no. 3; pp. S460 - S482
• Main Authors: Akerlund, Anders, Andersson, Morgan, Leflein, Jeffrey, Lildholdt, Torben, Mygind, Niels
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.03.2005; Elsevier Limited
• Subjects: Adolescent; Allergens - administration & dosage; Allergies; Anti-Allergic Agents - classification; Anti-Allergic Agents - therapeutic use; Child; Child, Preschool; Children & youth; Classification; Clinical trial design; Clinical trials; Drug therapy; Ear diseases; H 1-antihistamines; Humans; intermittent rhinitis; Intervention; intranasal steroids; LTRAs; Multicenter Studies as Topic - methods; nasal allergen challenge; nasal polyposis; Nasal Polyps - diagnosis; Nasal Polyps - drug therapy; Nasal Polyps - immunology; Nasal Provocation Tests - methods; Nose; Patients; pediatric rhinitis; perennial rhinitis; persistent rhinitis; Randomized Controlled Trials as Topic - methods; Rhinitis, Allergic, Perennial - diagnosis; Rhinitis, Allergic, Perennial - drug therapy; Rhinitis, Allergic, Perennial - immunology; Rhinitis, Allergic, Seasonal - diagnosis; Rhinitis, Allergic, Seasonal - drug therapy; Rhinitis, Allergic, Seasonal - immunology; seasonal rhinitis; Sinuses; nasal allergen challenge; pediatric rhinitis; PAR; SAR; OME; intranasal steroids; LTRAs; Clinical trial design; intermittent rhinitis; H 1-antihistamines; nasal polyposis; CT; seasonal rhinitis; LTRA; persistent rhinitis; perennial rhinitis; NPIF

Clinical trials in allergic rhinitis present several specific difficulties. In seasonal pollen-related disease, there are variations between subjects in the extent of pollen sensitization, individual variations in exposure to pollen even within a set area because of lifestyle differences, and variat...