An aptamer-integrated conductive microneedle biosensor for real-time transdermal cortisol monitoring

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Vol. 502; p. 157488
• Main Authors: Yue Jing, Li, Fan, Yangkai, Zhi Chen, Bo, Li, Dehui, Ting He, Yu, Liang Zhang, Guo, Liang, Ling, Du, Jie, Wang, Yuan, Dong Guo, Xin
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.12.2024
• Subjects: Aptamer; Cortisol; Dendritic Au nanoparticles; Electrochemical biosensor; Microneedles; Dendritic Au nanoparticles; Aptamer; Electrochemical biosensor; Cortisol; Microneedles

•A sensitive, stable, and selective microneedle biosensor was developed for real-time cortisol monitoring in interstitial fluid.•The sensitivity of aptamer-integrated microneedle sensor was boosted by depositing dendritic AuNPs on its surface.•Cortisol detection in healthy volunteers revealed circad...