Amphiphilic photocleavable block copolymers based on monomethyl poly(ethylene glycol) and poly(4-substituted-ε-caprolactone): synthesis, characterization, and cellular uptake

• Published in: RSC advances Vol. 3; no. 40; pp. 18453 - 18463
• Main Authors: Peng, Kang-Yu, Wang, Shiu-Wei, Hua, Mu-Yi, Lee, Ren-Shen
• Format: Journal Article
• Language: English
• Published: 01.01.2013
• Subjects: Biocompatibility; biodegradability; Block copolymers; Cellular; composite polymers; cytoplasm; doxorubicin; dyes; encapsulation; fluorescence; hydrophilicity; hydrophobicity; indomethacin; irradiation; lactones; Light irradiation; Micelles; nanoparticles; polyethylene glycol; Synthesis; Toxicity; Uptakes

This paper presents the synthesis of a novel amphiphilic block copolymer containing photodegradable linkers as junction points between hydrophilic and hydrophobic chains. MPEG-ONB-PXCL block copolymers were synthesized by a combination of ROP and "clicks" from a difunctional photoresponsiv...