Amphiphilic photocleavable block copolymers based on monomethyl poly(ethylene glycol) and poly(4-substituted-ε-caprolactone): synthesis, characterization, and cellular uptake

This paper presents the synthesis of a novel amphiphilic block copolymer containing photodegradable linkers as junction points between hydrophilic and hydrophobic chains. MPEG-ONB-PXCL block copolymers were synthesized by a combination of ROP and "clicks" from a difunctional photoresponsiv...

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Published inRSC advances Vol. 3; no. 40; pp. 18453 - 18463
Main Authors Peng, Kang-Yu, Wang, Shiu-Wei, Hua, Mu-Yi, Lee, Ren-Shen
Format Journal Article
LanguageEnglish
Published 01.01.2013
Subjects
Biocompatibility
biodegradability
Block copolymers
Cellular
composite polymers
cytoplasm
doxorubicin
dyes
encapsulation
fluorescence
hydrophilicity
hydrophobicity
indomethacin
irradiation
lactones
Light irradiation
Micelles
nanoparticles
polyethylene glycol
Synthesis
Toxicity
Uptakes
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Abstract This paper presents the synthesis of a novel amphiphilic block copolymer containing photodegradable linkers as junction points between hydrophilic and hydrophobic chains. MPEG-ONB-PXCL block copolymers were synthesized by a combination of ROP and "clicks" from a difunctional photoresponsive initiator (ONB). The copolymers are biodegradable and biocompatible, and can self-assemble into photoresponsive micelles. When polymer solutions were exposed to UV, we observed significant changes in the structure and morphology of particles. Fluorescence emission measurements showed that Nile red (NR), a hydrophobic dye, encapsulated by the MPEG-ONB-PXCL micelles, is released upon irradiation because of disruption of the micelles. Light-triggered bursts were observed for Indomethacin (IMC)-loaded MPEG-ONB-PXCL micelles upon at 30 min of light irradiation. No significant toxicity of these nanoparticles was found, at concentrations up to 1000 mu g mL super(-1), before or after light irradiation. The doxorubicin (DOX)-loaded micelles facilitated improved uptake of DOX by HeLa cells within 60 min, and were retained primarily in the cytoplasm.
AbstractList This paper presents the synthesis of a novel amphiphilic block copolymer containing photodegradable linkers as junction points between hydrophilic and hydrophobic chains. MPEG-ONB-PXCL block copolymers were synthesized by a combination of ROP and “clicks” from a difunctional photoresponsive initiator (ONB). The copolymers are biodegradable and biocompatible, and can self-assemble into photoresponsive micelles. When polymer solutions were exposed to UV, we observed significant changes in the structure and morphology of particles. Fluorescence emission measurements showed that Nile red (NR), a hydrophobic dye, encapsulated by the MPEG-ONB-PXCL micelles, is released upon irradiation because of disruption of the micelles. Light-triggered bursts were observed for Indomethacin (IMC)-loaded MPEG-ONB-PXCL micelles upon at 30 min of light irradiation. No significant toxicity of these nanoparticles was found, at concentrations up to 1000 μg mL⁻¹, before or after light irradiation. The doxorubicin (DOX)-loaded micelles facilitated improved uptake of DOX by HeLa cells within 60 min, and were retained primarily in the cytoplasm.
This paper presents the synthesis of a novel amphiphilic block copolymer containing photodegradable linkers as junction points between hydrophilic and hydrophobic chains. MPEG-ONB-PXCL block copolymers were synthesized by a combination of ROP and "clicks" from a difunctional photoresponsive initiator (ONB). The copolymers are biodegradable and biocompatible, and can self-assemble into photoresponsive micelles. When polymer solutions were exposed to UV, we observed significant changes in the structure and morphology of particles. Fluorescence emission measurements showed that Nile red (NR), a hydrophobic dye, encapsulated by the MPEG-ONB-PXCL micelles, is released upon irradiation because of disruption of the micelles. Light-triggered bursts were observed for Indomethacin (IMC)-loaded MPEG-ONB-PXCL micelles upon at 30 min of light irradiation. No significant toxicity of these nanoparticles was found, at concentrations up to 1000 mu g mL super(-1), before or after light irradiation. The doxorubicin (DOX)-loaded micelles facilitated improved uptake of DOX by HeLa cells within 60 min, and were retained primarily in the cytoplasm.
Author Lee, Ren-Shen
Peng, Kang-Yu
Hua, Mu-Yi
Wang, Shiu-Wei
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SubjectTerms Biocompatibility
biodegradability
Block copolymers
Cellular
composite polymers
cytoplasm
doxorubicin
dyes
encapsulation
fluorescence
hydrophilicity
hydrophobicity
indomethacin
irradiation
lactones
Light irradiation
Micelles
nanoparticles
polyethylene glycol
Synthesis
Toxicity
Uptakes
Title Amphiphilic photocleavable block copolymers based on monomethyl poly(ethylene glycol) and poly(4-substituted-ε-caprolactone): synthesis, characterization, and cellular uptake
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