Copper acetate - Iodine co-mediated thiolation of 2-arylpyridines with thiophenol

Copper acetate - iodine co-mediated regioselective ortho-arylthiolation of 2-arylpyridines has been accomplished with inexpensive and convenient thiophenol as the arylthiolating reagent. This protocol features excellent functional group tolerance, generating thioarylated products in moderate-to-high...

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Bibliographic Details
Published inTetrahedron Vol. 103; pp. 132552 - 132558
Main Authors He, Yayun, Hou, Senpeng, Hu, Junhao
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.01.2022
Elsevier
Subjects
2-arylpyridines
Chemistry
Chemistry, Organic
Copper acetate
Orthoarylthiolation
Physical Sciences
Science & Technology
Thiophenol
2-arylpyridines
Thiophenol
Orthoarylthiolation
Copper acetate
H FUNCTIONALIZATION
CHALCOGENATION
TRIFLUOROMETHYLTHIOLATION
ARENES
SULFENYLATION
N BOND-FORMATION
DISULFIDES
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Summary:Copper acetate - iodine co-mediated regioselective ortho-arylthiolation of 2-arylpyridines has been accomplished with inexpensive and convenient thiophenol as the arylthiolating reagent. This protocol features excellent functional group tolerance, generating thioarylated products in moderate-to-high yields. © 2021 Elsevier Science. All rights reserved. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2021.132552