M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy
M1 muscarinic receptors (M1 mAChRs) play a role in an apparent linkage of three major hallmarks of Alzheimer's disease (AD): beta-amyloid (Abeta) peptide; tau hyperphosphorylation and paired helical filaments (PHFs); and loss of cholinergic function conducive to cognitive impairments. We evalua...
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Published in | Journal of molecular neuroscience Vol. 20; no. 3; pp. 349 - 356 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
2003
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Subjects | |
Online Access | Get full text |
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