Transforming growth factor-beta enhances rhinovirus infection by diminishing early innate responses

• Published in: American journal of respiratory cell and molecular biology Vol. 41; no. 3; pp. 339 - 347
• Main Authors: Thomas, Belinda J, Lindsay, Mandy, Dagher, Hayat, Freezer, Nicholas J, Li, Dongsheng, Ghildyal, Reena, Bardin, Philip G
• Format: Journal Article
• Language: English
• Published: United States 01.09.2009
• Subjects: Adult; Asthma - immunology; Asthma - virology; Cell Death - physiology; Cell Differentiation - physiology; Cells, Cultured; Chemokines - immunology; Child; Fibroblasts - cytology; Fibroblasts - immunology; Fibroblasts - virology; Humans; Immunity, Innate - physiology; Interferon Regulatory Factor-3 - metabolism; Interferon Type I - immunology; Interleukin-8 - genetics; Interleukin-8 - metabolism; Neutrophils - immunology; Picornaviridae Infections - immunology; Respiratory Mucosa - cytology; Rhinovirus - physiology; Signal Transduction - physiology; Transforming Growth Factor beta1 - metabolism; Virus Replication - physiology

Individuals with asthma are prone to viral and bacterial infections, and most asthma exacerbations have been linked to viruses, particularly rhinovirus. Excess transforming growth factor (TGF)-beta present in asthmatic airways may cause immune suppression, as well as transdifferentiate fibroblasts t...