Synthesis of new condensed nitrogen heterocyclic systems

• Published in: Tetrahedron Vol. 64; no. 6; pp. 1071 - 1076
• Main Authors: Korbonits, Dezső, Podányi, Benjamin, Illár, Árpád, Simon, Kálmán, Hanusz, Miklós, Hermecz, István
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 04.02.2008; Elsevier
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; ISOQUINOLINIUM CATIONS; QUINOLINIUM; ASYMMETRIC-SYNTHESIS; PSEUDOBASE FORMATION; EQUILIBRIUM

A cotarnine alkaloid-based synthesis was developed for new heptacyclic condensed diisoquinolines via the double intramolecular pseudosalt bis[1,3]dioxolo[4,5- g;4′,5′- g′][1,3,4]oxadiazolo[2,3- a;5,4- a′]diisoquinoline 6. Substitution of the central O atom in 6 by C, S, or N nucleophiles afforded th...