An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β‐thalassemia major patients: A double‐blind randomized controlled clinical trial

• Published in: Phytotherapy research Vol. 32; no. 9; pp. 1828 - 1835
• Main Authors: Mohammadi, Elahe, Tamaddoni, Ahmad, Qujeq, Durdi, Nasseri, Esmat, Zayeri, Farid, Zand, Hamid, Gholami, Mahdi, Mir, Seyed Mostafa
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.09.2018
• Subjects: Adult; Alanine; Alanine transaminase; Alanine Transaminase - metabolism; analysis of covariance; Aspartate aminotransferase; Aspartate Aminotransferases - metabolism; aspartate transaminase; beta-Thalassemia - drug therapy; binding capacity; blood serum; Clinical trials; Covariance; Curcuma - chemistry; Curcumin; Curcumin - therapeutic use; Diet; Dietary intake; Double-Blind Method; Double-blind studies; Female; Ferritin; Ferritins - blood; food intake; Hemoglobin; Hemoglobins - analysis; Hepcidin; Hepcidins - blood; Humans; Iron; Iron - blood; iron overload; Iron Overload - drug therapy; Liver; Liver - metabolism; Liver diseases; liver function; Male; Patients; placebos; polyphenols; Randomization; randomized clinical trial; Serum levels; Thalassemia; Transferrin; Transferrins; turmeric; Young Adult; β‐thalassemia major; iron overload; randomized clinical trial; hepcidin; β-thalassemia major; curcumin

This study investigated the effects of curcumin, the active polyphenol in turmeric, on iron overload, hepcidin level, and liver function in β‐thalassemia major patients. This double‐blind randomized controlled clinical trial was conducted on 68 β‐thalassemia major patients. The subjects were randoml...