Fabrication of pH‐Responsive Hydrogel and Its In Vitro and In Vivo Evaluation

• Published in: Advances in polymer technology Vol. 37; no. 1; pp. 290 - 304
• Main Authors: Tulain, Ume Ruqia, Ahmad, Mahmood, Rashid, Ayesha, Malik, Muhammad Zubair, Iqbal, Furqan Muhammad
• Format: Journal Article
• Language: English
• Published: London John Wiley & Sons, Inc 01.02.2018
• Subjects: Controlled release; Copolymerization; Drug delivery systems; Formulations; Free radical polymerization; Graft copolymer; Graft copolymers; HPLC chromatography; Hydrogels; In vivo analysis; In vivo methods and tests; Kinetic Models; Pharmacology; pH‐Responsive hydrogels; Rabeprazole sodium; Stomach; Swelling; Thermal analysis

ABSTRACT The present research work deals with the development of pH‐responsive hydrogel by free radical polymerization in aqueous media to protect the rabeprazole sodium from acidic environment of stomach. Swelling behavior of hydrogels that was observed in buffer of various pH indicated highly pH‐d...