Assessment of FMO3 SNPs in Relation to TMAO in Generally Healthy United States Adults

• Published in: Current developments in nutrition Vol. 5; no. Supplement_2; p. 940
• Main Authors: James, Kristen, Gertz, Erik, Kirschke, Catherine, Huang, Liping, Stephensen, Charles, Bennett, Brian
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Inc 01.06.2021; Oxford University Press
• Subjects: Enzymes; Nutrient-Gene Interactions; Womens health

The hepatic enzyme flavin monooxygenase 3 (FMO3) oxidizes many metabolites including trimethylamine to the atherogenic molecule trimethylamine n-oxide (TMAO). Variants in the open reading frame of the FMO3 gene alter the enzyme’s activity; therefore, we genotyped two a priori missense FMO3 SNPs in a...