Adenosine-Activated Mast Cells Induce IgE Synthesis by B Lymphocytes: An A2B-Mediated Process Involving Th2 Cytokines IL-4 and IL-13 with Implications for Asthma

• Published in: The Journal of immunology (1950) Vol. 172; no. 12; pp. 7726 - 7733
• Main Authors: Ryzhov, Sergey, Goldstein, Anna E, Matafonov, Anton, Zeng, Dewan, Biaggioni, Italo, Feoktistov, Igor
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.06.2004
• Subjects: Adenosine - pharmacology; Adenosine-5'-(N-ethylcarboxamide) - pharmacology; Asthma - etiology; B-Lymphocytes - immunology; B-Lymphocytes - physiology; Cell Communication - immunology; Cells, Cultured; Coculture Techniques; Cytokines - genetics; Humans; Immunoglobulin E - biosynthesis; Interleukin-13 - immunology; Interleukin-4 - immunology; Mast Cells - immunology; Mast Cells - physiology; Receptor, Adenosine A2B - physiology; RNA, Messenger - biosynthesis; Th2 Cells - immunology; Up-Regulation - immunology

Adenosine provokes bronchoconstriction in asthmatics through acute activation of mast cells, but its potential role in chronic inflammation has not been adequately characterized. We hypothesized that adenosine up-regulates Th2 cytokines in mast cells, thus promoting IgE synthesis by B lymphocytes. W...