Mathematical modeling of ovarian follicle development: A population dynamics viewpoint

Among endocrine organs, ovaries are unique because their function is supported by an ever-changing number of histological entities, the ovarian follicles, which are themselves subject to asynchronous development from their formation up to ovulation. Follicle development combines finely controlled pr...

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Bibliographic Details
Published inCurrent opinion in endocrine and metabolic research Vol. 18; pp. 54 - 61
Main Authors Clément, Frédérique, Monniaux, Danielle
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.06.2021
Elsevier
Subjects
Cell fate
Cell kinetics
Life Sciences
Morphogenesis
Multiscale models
Ovarian follicles
Population dynamics
Regression models
Structured populations
Morphogenesis
Regression models
Multiscale models
Cell fate
Cell kinetics
Population dynamics
Structured populations
Ovarian follicles
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Summary:Among endocrine organs, ovaries are unique because their function is supported by an ever-changing number of histological entities, the ovarian follicles, which are themselves subject to asynchronous development from their formation up to ovulation. Follicle development combines finely controlled processes of cell dynamics with original morphogenesis steps. Understanding the dynamics of follicle populations, on the whole ovary level, and the coupled dynamics of the oocyte and somatic cells, on the follicle level, is crucial to understand ovarian physiology and ovarian aging. Mathematical modeling studies combined with proper experimental approaches can be particularly helpful for gaining insight into follicle dynamics on different scales.
ISSN:2451-9650
2451-9650
DOI:10.1016/j.coemr.2021.02.003