The multifaceted therapeutic potential of propolis: an integrative report on its pharmacological properties and emerging advances

Propolis, a resinous apicultural product by honeybees collected from botanical exudates, has been traditionally used in folk medicine and has recently garnered substantial scientific interest due to its diverse pharmacological properties. This report examines the chemical complexity, antimicrobial,...

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Published inDiscover applied sciences Vol. 7; no. 9; pp. 962 - 11
Main Authors Ballouk, Muhammed Al-Huda, Altinawi, Mohamed, Fudalej, Piotr S.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.09.2025
Springer Nature B.V
Springer
Subjects
Antibiotics
Antimicrobial agents
Antioxidants
Apiculture
Apitherapy
Applied and Technical Physics
Bacteria
Bioavailability
Biocompatible materials
Biotechnology
Brief Report
Chemical composition
Chemistry/Food Science
Chronic illnesses
Clinical trials
Complementary therapies
Complexity
COVID-19
Delivery of health care
Dentistry
DNA methylation
Drug resistance
Earth Sciences
Engineering
Environment
Enzymes
Epigenetics
Exudates
Flavonoids
Growth factors
Immunomodulation
Kinases
Mass spectrometry
Materials Science
Medicine
Multidrug resistant organisms
Nanotechnology
Natural products
Neuroprotection
NMR
Nuclear magnetic resonance
Patient safety
Pharmacology
Phytochemicals
Precision medicine
Production methods
Propolis
Proteins
Quality control
Resins
Staphylococcus infections
Toxicity
Wound healing
Complementary therapies
Medicine
Pharmacy
Propolis
Biocompatible materials
Delivery of health care
Dentistry
Apitherapy
Online AccessGet full text
ISSN3004-9261
2523-3963
3004-9261
2523-3971
DOI10.1007/s42452-025-07648-0

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Abstract Propolis, a resinous apicultural product by honeybees collected from botanical exudates, has been traditionally used in folk medicine and has recently garnered substantial scientific interest due to its diverse pharmacological properties. This report examines the chemical complexity, antimicrobial, anti-inflammatory, and antioxidant activities of propolis. Emphasis is placed on the most recent technological and therapeutic advances, including nanobiotechnological formulations, molecular targeting in oncology, immunomodulation in viral infections, neuroprotective potential, and biotechnological production methods. Challenges and limitations related to standardization and clinical translation of propolis applications are also discussed, highlighting the future directions for propolis research as a promising natural therapeutic agent. Highlights Propolis is a complex natural product with a highly variable chemical composition that underpins its broad-spectrum beneficial effects. Recent innovations include nanotechnology-based delivery systems and biotechnological production methods that enhance propolis’s bioavailability and therapeutic potential. Cutting-edge research has expanded propolis’s medicinal roles into highlighting its versatility in modern medicine. Future efforts should focus on personalized medicine approaches and large-scale randomized controlled studies to fully realize propolis’s clinical utility.
AbstractList Propolis, a resinous apicultural product by honeybees collected from botanical exudates, has been traditionally used in folk medicine and has recently garnered substantial scientific interest due to its diverse pharmacological properties. This report examines the chemical complexity, antimicrobial, anti-inflammatory, and antioxidant activities of propolis. Emphasis is placed on the most recent technological and therapeutic advances, including nanobiotechnological formulations, molecular targeting in oncology, immunomodulation in viral infections, neuroprotective potential, and biotechnological production methods. Challenges and limitations related to standardization and clinical translation of propolis applications are also discussed, highlighting the future directions for propolis research as a promising natural therapeutic agent.HighlightsPropolis is a complex natural product with a highly variable chemical composition that underpins its broad-spectrum beneficial effects.Recent innovations include nanotechnology-based delivery systems and biotechnological production methods that enhance propolis’s bioavailability and therapeutic potential.Cutting-edge research has expanded propolis’s medicinal roles into highlighting its versatility in modern medicine.Future efforts should focus on personalized medicine approaches and large-scale randomized controlled studies to fully realize propolis’s clinical utility.
Propolis, a resinous apicultural product by honeybees collected from botanical exudates, has been traditionally used in folk medicine and has recently garnered substantial scientific interest due to its diverse pharmacological properties. This report examines the chemical complexity, antimicrobial, anti-inflammatory, and antioxidant activities of propolis. Emphasis is placed on the most recent technological and therapeutic advances, including nanobiotechnological formulations, molecular targeting in oncology, immunomodulation in viral infections, neuroprotective potential, and biotechnological production methods. Challenges and limitations related to standardization and clinical translation of propolis applications are also discussed, highlighting the future directions for propolis research as a promising natural therapeutic agent. Highlights Propolis is a complex natural product with a highly variable chemical composition that underpins its broad-spectrum beneficial effects. Recent innovations include nanotechnology-based delivery systems and biotechnological production methods that enhance propolis’s bioavailability and therapeutic potential. Cutting-edge research has expanded propolis’s medicinal roles into highlighting its versatility in modern medicine. Future efforts should focus on personalized medicine approaches and large-scale randomized controlled studies to fully realize propolis’s clinical utility.
Abstract Propolis, a resinous apicultural product by honeybees collected from botanical exudates, has been traditionally used in folk medicine and has recently garnered substantial scientific interest due to its diverse pharmacological properties. This report examines the chemical complexity, antimicrobial, anti-inflammatory, and antioxidant activities of propolis. Emphasis is placed on the most recent technological and therapeutic advances, including nanobiotechnological formulations, molecular targeting in oncology, immunomodulation in viral infections, neuroprotective potential, and biotechnological production methods. Challenges and limitations related to standardization and clinical translation of propolis applications are also discussed, highlighting the future directions for propolis research as a promising natural therapeutic agent.
ArticleNumber 962
Author Ballouk, Muhammed Al-Huda
Fudalej, Piotr S.
Altinawi, Mohamed
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  givenname: Piotr S.
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  fullname: Fudalej, Piotr S.
  organization: Department of Orthodontics, School of Dental Medicine, Medical Faculty, University of Bern, Department of Orthodontics, Institute of Dentistry, Medical Faculty, Jagiellonian University
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Issue 9
Keywords Complementary therapies
Medicine
Pharmacy
Propolis
Biocompatible materials
Delivery of health care
Dentistry
Apitherapy
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Snippet Propolis, a resinous apicultural product by honeybees collected from botanical exudates, has been traditionally used in folk medicine and has recently garnered...
Abstract Propolis, a resinous apicultural product by honeybees collected from botanical exudates, has been traditionally used in folk medicine and has recently...
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SubjectTerms Antibiotics
Antimicrobial agents
Antioxidants
Apiculture
Apitherapy
Applied and Technical Physics
Bacteria
Bioavailability
Biocompatible materials
Biotechnology
Brief Report
Chemical composition
Chemistry/Food Science
Chronic illnesses
Clinical trials
Complementary therapies
Complexity
COVID-19
Delivery of health care
Dentistry
DNA methylation
Drug resistance
Earth Sciences
Engineering
Environment
Enzymes
Epigenetics
Exudates
Flavonoids
Growth factors
Immunomodulation
Kinases
Mass spectrometry
Materials Science
Medicine
Multidrug resistant organisms
Nanotechnology
Natural products
Neuroprotection
NMR
Nuclear magnetic resonance
Patient safety
Pharmacology
Phytochemicals
Precision medicine
Production methods
Propolis
Proteins
Quality control
Resins
Staphylococcus infections
Toxicity
Wound healing
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Title The multifaceted therapeutic potential of propolis: an integrative report on its pharmacological properties and emerging advances
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Volume 7
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