Multibarrier-penetrating drug delivery systems for deep tumor therapy based on synergistic penetration strategy

• Published in: Biomaterials science Vol. 12; no. 9; pp. 2321 - 233
• Main Authors: Zhang, Hui-Feng, Yu, Huan, Pan, Shuang-Xue, Zhang, Chuang, Ma, Ying-Hui, Zhang, Yan-Fei, Zuo, Li-Li, Hao, Cheng-Yi, Lin, Xiao-Ying, Geng, Hao, Wu, Di, Mu, Shang-Qiang, Yu, Wei-Lun, Shi, Nian-Qiu
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 30.04.2024
• Subjects: Anticancer properties; Assaying; Biocompatibility; Biomedical materials; Cell membranes; Doxorubicin; Drug delivery systems; Effectiveness; Liposomes; Peptides; Scanning microscopy; Toxicity

Nanotherapies, valued for their high efficacy and low toxicity, frequently serve as antitumor treatments, but do not readily penetrate deep into tumor tissues and cells. Here we developed an improved tumor-penetrating peptide (TPP)-based drug delivery system. Briefly, the established TPP iNGR was mo...