Near-infrared fluorescent probes based on naphthyridine derivatives for mitochondrial nucleic acid imaging

• Published in: Analyst (London) Vol. 15; no. 4; pp. 642 - 649
• Main Authors: Ma, Huan, Ni, Wen-Pei, Lin, Qi, Sun, Ru, Ge, Jian-Feng
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 10.02.2025
• Subjects: Acid digestion; Aldehydes; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA, Mitochondrial - analysis; DNA, Mitochondrial - chemistry; Emission; Fluorescent dyes; Fluorescent Dyes - chemical synthesis; Fluorescent Dyes - chemistry; Fluorescent Dyes - radiation effects; Fluorescent Dyes - toxicity; Fluorescent indicators; HeLa Cells; Humans; Infrared imaging; Mitochondria - metabolism; Naphthyridines - chemical synthesis; Naphthyridines - chemistry; Naphthyridines - radiation effects; Naphthyridines - toxicity; Near infrared radiation; Nucleic acids; Optical Imaging - methods; Ribonucleic acid; RNA; RNA - analysis; RNA - chemistry; RNA - metabolism; Spectrometry, Fluorescence

Most current nucleic acid-responsive fluorescent probes are enhanced ones with short emission wavelengths. Therefore, the development of novel near-infrared, turn-on response nucleic acid fluorescent probes is of great significance. Herein, three cationic fluorescent dyes 1a-1c were synthesized by r...