Glycosyl oxazolines serve as active donors for iterative synthesis of type I oligosaccharides

• Published in: Chemical communications (Cambridge, England) Vol. 6; no. 84; pp. 12173 - 12176
• Main Authors: Verma, Nitish, Tu, Zhijay, Renata, Septila, Lin, Chun-Hung
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 17.10.2024; Royal Society of Chemistry
• Subjects: Carbohydrates; Chemistry; Chemistry, Multidisciplinary; Disaccharides; Oligosaccharides; Physical Sciences; Science & Technology; Synthesis; MANNAN-BINDING PROTEIN; CHAIN; LIGANDS; LACTOSYLCERAMIDES

Synthesis of Galβ1 → 3GlcNAc-repeating saccharides is limited mainly by the formation of less-reactive oxazolines. We herein report an expeditious approach that requires trichloroacetyloxazolines as reactive glycosyl donors. Using only two disaccharide building blocks, the iterative oxazoline format...