1H NMR-based metabolomics approach to evaluate the effect of Xue-Fu-Zhu-Yu decoction on hyperlipidemia rats induced by high-fat diet
[Display omitted] ► Effect of XFZYD on hyperlipidemia rats were investigated by NMR-based metabolomics. ► Seventeen marker metabolites were indentified to be hyperlipidemia concerned. ► Six isolated pathways were identified to be implicated in hyperlipidemia. ► The anti-hyperlipidemia efficacy of XF...
Saved in:
| Published in | Journal of pharmaceutical and biomedical analysis Vol. 78-79; pp. 202 - 210 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
05.05.2013
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | [Display omitted]
► Effect of XFZYD on hyperlipidemia rats were investigated by NMR-based metabolomics. ► Seventeen marker metabolites were indentified to be hyperlipidemia concerned. ► Six isolated pathways were identified to be implicated in hyperlipidemia. ► The anti-hyperlipidemia efficacy of XFZYD was confirmed firstly in a global scale. ► Metabolomics is helpful for understanding of the hyperlipidemia-related mechanisms.
An NMR-based metabolomics approach was conducted to holisticly explore the effect of XFZYD (a traditional Chinese medicine formula) on high-fat diet induced hyperlipidemia rats with one of the commonly used antihyperlipidemic agents, simvastatin as the positive control. NMR spectra from blood plasma combined with statistical analysis revealed compounds distinguishing hyperlipidemia rats from normal control rats. XFZYD could ameliorate hyperlipidemia by intervening in some major metabolic pathways, such as decreasing the accumulation of ketone body (β-hydroxybutyrate) and acetyl-glycoproteins, enhancing glutathione (GSH) biosynthesis, partially reversing energy and lipid metabolism disturbance. Oral administration of XFZYD could also be helpful to hyperlipidemia rats in bettering the serum chemistry profile. The combined results demonstrated that XFZYD could ameliorate the hyperlipidemic symptoms in a global scale and restore the abnormal metabolic state to a near normal level in a time-dependent pattern. |
|---|---|
| AbstractList | [Display omitted]
► Effect of XFZYD on hyperlipidemia rats were investigated by NMR-based metabolomics. ► Seventeen marker metabolites were indentified to be hyperlipidemia concerned. ► Six isolated pathways were identified to be implicated in hyperlipidemia. ► The anti-hyperlipidemia efficacy of XFZYD was confirmed firstly in a global scale. ► Metabolomics is helpful for understanding of the hyperlipidemia-related mechanisms.
An NMR-based metabolomics approach was conducted to holisticly explore the effect of XFZYD (a traditional Chinese medicine formula) on high-fat diet induced hyperlipidemia rats with one of the commonly used antihyperlipidemic agents, simvastatin as the positive control. NMR spectra from blood plasma combined with statistical analysis revealed compounds distinguishing hyperlipidemia rats from normal control rats. XFZYD could ameliorate hyperlipidemia by intervening in some major metabolic pathways, such as decreasing the accumulation of ketone body (β-hydroxybutyrate) and acetyl-glycoproteins, enhancing glutathione (GSH) biosynthesis, partially reversing energy and lipid metabolism disturbance. Oral administration of XFZYD could also be helpful to hyperlipidemia rats in bettering the serum chemistry profile. The combined results demonstrated that XFZYD could ameliorate the hyperlipidemic symptoms in a global scale and restore the abnormal metabolic state to a near normal level in a time-dependent pattern. |
| Author | Tian, Na Wang, Junsong Yang, Minghua Wang, Pengran Song, Xingfang Kong, Lingyi |
| Author_xml | – sequence: 1 givenname: Xingfang surname: Song fullname: Song, Xingfang – sequence: 2 givenname: Junsong surname: Wang fullname: Wang, Junsong email: wang.junsong@gmail.com – sequence: 3 givenname: Pengran surname: Wang fullname: Wang, Pengran – sequence: 4 givenname: Na surname: Tian fullname: Tian, Na – sequence: 5 givenname: Minghua surname: Yang fullname: Yang, Minghua – sequence: 6 givenname: Lingyi surname: Kong fullname: Kong, Lingyi email: cpu_lykong@126.com |
| BookMark | eNp9kM1q3TAQRkVJITdJXyArvYDckfwP3ZTQNIW0hZJC2o0YS6NaF1_LSHLg7vvg8SVddREY-FZn5ptzwc7mMBNj1xIKCbJ5vy_2y4CFAlkWoAqQ1Ru2k11bCtVUj2dsB20pRQtdfc4uUtoDQC37asf-yjv-7esPMWAiyw-UcQhTOHiTOC5LDGhGngOnJ5xWzMTzSJycI5N5cPxxJXG7it_jKn6t3JIJJvsw823G40Jx8ou3dPDII-bE_WxXs50Zjnz0f0bhMHPrKV-xtw6nRO_-5SX7efvp4eZO3H___OXm470wqm-yKE1jTNU41_d1ZXGABmyvWux6o5zrQIFyVQOSFNVS4eCo7LHq60HZumkJy0vWvew1MaQUyWnjM54a54h-0hL0yabe65NNfbKpQenN5oaq_9Al-gPG4-vQhxeItqeePEWdjKd5U-DjZlDb4F_DnwGcD5IX |
| CitedBy_id | crossref_primary_10_1038_srep40318 crossref_primary_10_1016_j_anifeedsci_2020_114797 crossref_primary_10_1016_j_trac_2014_05_013 crossref_primary_10_1039_C5RA27273D crossref_primary_10_1038_s41366_024_01695_0 crossref_primary_10_1155_2018_2154603 crossref_primary_10_1186_s12967_016_0987_5 crossref_primary_10_1016_j_jpba_2017_02_015 crossref_primary_10_1111_rda_12919 crossref_primary_10_1016_j_fbio_2022_101667 crossref_primary_10_3390_nu13103573 crossref_primary_10_1016_j_taap_2017_07_013 crossref_primary_10_1016_j_ijbiomac_2020_05_003 crossref_primary_10_1016_j_jep_2014_03_050 crossref_primary_10_1155_2018_1854972 crossref_primary_10_1155_2019_5897675 crossref_primary_10_1002_jssc_202000911 crossref_primary_10_1039_D0RA06577C crossref_primary_10_1111_1750_3841_15549 crossref_primary_10_1016_j_foodchem_2014_09_161 crossref_primary_10_3390_biom14080884 crossref_primary_10_1016_j_jpha_2014_04_002 crossref_primary_10_1016_j_fct_2023_113971 crossref_primary_10_18632_oncotarget_21876 crossref_primary_10_1007_s12010_016_2352_9 crossref_primary_10_1039_C3MB70609E crossref_primary_10_1117_1_JBO_21_2_025008 crossref_primary_10_1371_journal_pone_0108678 crossref_primary_10_1186_s12944_017_0633_0 crossref_primary_10_1021_acs_jafc_5b05350 crossref_primary_10_1155_2016_2391592 crossref_primary_10_1155_2019_5920485 crossref_primary_10_18325_jkmr_2016_26_1_1 crossref_primary_10_1002_bmc_5707 crossref_primary_10_1021_acs_jafc_5b01590 crossref_primary_10_1016_j_jprot_2017_10_010 crossref_primary_10_1039_C4MB00370E crossref_primary_10_1002_jssc_201600083 crossref_primary_10_1021_acs_jproteome_8b00330 crossref_primary_10_1016_j_foodres_2020_109547 crossref_primary_10_1039_D0AY00305K crossref_primary_10_1002_cbdv_202000122 crossref_primary_10_1016_j_jpba_2015_01_029 crossref_primary_10_1039_C5AY00023H crossref_primary_10_1016_j_jep_2020_112780 crossref_primary_10_1016_j_jfda_2015_06_004 crossref_primary_10_1007_s12600_018_0682_6 crossref_primary_10_1155_2021_9920416 crossref_primary_10_1111_jfbc_14392 crossref_primary_10_1016_j_foodres_2018_10_011 crossref_primary_10_1016_j_jff_2016_11_011 crossref_primary_10_1016_j_taap_2017_01_007 crossref_primary_10_1016_j_jpba_2020_113869 crossref_primary_10_3389_fphar_2023_1233156 crossref_primary_10_3390_molecules24132380 crossref_primary_10_1016_j_jep_2019_111908 crossref_primary_10_1155_2020_5463652 crossref_primary_10_1210_en_2015_1015 crossref_primary_10_1016_j_jep_2018_01_020 crossref_primary_10_1155_2020_1247946 crossref_primary_10_1002_bmc_4872 crossref_primary_10_1038_s41598_017_11422_7 crossref_primary_10_1016_j_jep_2015_03_047 crossref_primary_10_1155_2017_6091589 crossref_primary_10_1016_j_aquatox_2013_10_024 crossref_primary_10_1017_S0007114522003166 crossref_primary_10_1016_j_biopha_2020_110448 crossref_primary_10_1155_2014_925302 crossref_primary_10_3390_nu12113511 crossref_primary_10_1016_j_jchromb_2016_02_011 crossref_primary_10_1016_S1875_5364_21_60011_0 crossref_primary_10_1039_C7FO00081B crossref_primary_10_1142_S0192415X15500779 crossref_primary_10_1016_j_jpba_2013_08_025 crossref_primary_10_1039_C6FO01753C crossref_primary_10_1016_j_ctim_2019_02_008 crossref_primary_10_1002_ptr_5240 crossref_primary_10_1242_bio_031534 crossref_primary_10_1016_S1995_7645_14_60142_5 crossref_primary_10_1039_C5TX00115C crossref_primary_10_1016_j_cbi_2017_06_011 crossref_primary_10_1016_j_jchromb_2015_10_014 crossref_primary_10_1016_j_mri_2017_01_009 crossref_primary_10_1371_journal_pone_0171628 |
| Cites_doi | 10.1007/s11655-010-0050-y 10.1248/cpb.52.1295 10.1007/s00216-007-1790-1 10.1016/j.atherosclerosis.2009.01.040 10.1016/j.jep.2011.01.033 10.1016/j.cbi.2008.05.018 10.1161/01.CIR.0000109698.70638.2B 10.1161/01.ATV.0000183928.25844.f6 10.1590/S0100-879X2006000200004 10.1056/NEJM198307213090307 10.1016/j.jep.2005.01.051 10.1172/JCI200422422 10.1007/s11655-010-9999-9 10.1016/j.pharmthera.2006.03.003 10.1093/jn/130.11.2760 10.1023/A:1018975928974 10.1093/carcin/21.10.1843 10.1079/BJN2002725 10.1016/j.nut.2009.05.023 10.1016/j.jep.2005.01.013 10.1021/ac051632c 10.1016/j.jep.2011.03.012 10.1046/j.1523-1755.1999.055003778.x 10.1042/CS20030326 10.1021/pr100892r 10.1016/S0261-5614(03)00059-1 10.1021/pr100862t 10.1158/1078-0432.CCR-08-2093 10.1021/pr900668v 10.1021/pr901203w 10.1021/pr901019z 10.1016/S0895-7061(97)00315-4 10.1055/s-2005-871231 10.1097/00000658-199202000-00004 |
| ContentType | Journal Article |
| Copyright | 2013 Elsevier B.V. |
| Copyright_xml | – notice: 2013 Elsevier B.V. |
| DBID | AAYXX CITATION |
| DOI | 10.1016/j.jpba.2013.02.014 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1873-264X |
| EndPage | 210 |
| ExternalDocumentID | 10_1016_j_jpba_2013_02_014 S0731708513000745 |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 4.4 457 4G. 5GY 5VS 7-5 71M 8P~ 9JM 9JN AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AATCM AAXUO ABFRF ABJNI ABMAC ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADECG ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AFZHZ AGHFR AGUBO AGYEJ AIEXJ AIKHN AITUG AJBFU AJOXV AJSZI ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC C45 CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FLBIZ FNPLU FYGXN G-Q GBLVA IHE J1W KOM M34 M36 M41 MO0 N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 RIG RNS ROL RPZ SCC SCH SDF SDG SDP SES SPC SPCBC SSK SSP SSZ T5K TEORI YK3 ~G- 29L 53G AAQXK AATTM AAXKI AAYWO AAYXX ABFNM ABWVN ACNNM ACRPL ACVFH ADCNI ADMUD ADNMO AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AHHHB AIGII AIIUN AJQLL AKBMS AKRWK AKYEP ANKPU APXCP ASPBG AVWKF AZFZN BNPGV CITATION FEDTE FGOYB G-2 HMT HMU HVGLF HZ~ R2- SCB SEW SPT SSH WUQ XPP |
| ID | FETCH-LOGICAL-c296t-3c6cc46ff9954dab060d927a89c2ff80202f4601e2e512abfe39a495b2d567ea3 |
| IEDL.DBID | .~1 |
| ISSN | 0731-7085 |
| IngestDate | Tue Jul 01 01:17:30 EDT 2025 Thu Apr 24 23:11:50 EDT 2025 Fri Feb 23 02:34:17 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Traditional Chinese medicines Metabolomics 1H NMR spectroscopy Hyperlipidemia OPLS-DA Xue-Fu-Zhu-Yu decoction |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c296t-3c6cc46ff9954dab060d927a89c2ff80202f4601e2e512abfe39a495b2d567ea3 |
| PageCount | 9 |
| ParticipantIDs | crossref_citationtrail_10_1016_j_jpba_2013_02_014 crossref_primary_10_1016_j_jpba_2013_02_014 elsevier_sciencedirect_doi_10_1016_j_jpba_2013_02_014 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2013-05-05 |
| PublicationDateYYYYMMDD | 2013-05-05 |
| PublicationDate_xml | – month: 05 year: 2013 text: 2013-05-05 day: 05 |
| PublicationDecade | 2010 |
| PublicationTitle | Journal of pharmaceutical and biomedical analysis |
| PublicationYear | 2013 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Kim, Kim, Noh, Hur, Sung, Hwang, Park, Yang, Kim, Kwon (bib0120) 2010; 10 Choudhary, Naheed, Jalil, Alam, Attaur (bib0005) 2005; 98 Jang, Srinivasan, Lee, Song, Lee, Lee, Jo (bib0080) 2008; 174 Shimizu, Shirakami, Iwasa, Shiraki, Yasuda, Hata, Hirose, Tsurumi, Tanaka, Moriwaki (bib0175) 2009; 15 Vinaixa, Ángel Rodríguez, Rull, Beltrán, Bladé, Brezmes, Cañellas, Joven, Correig (bib0015) 2010; 9 Shitara, Sugiyama (bib0020) 2006; 112 Hou, Zhao, Yuan, Zhu, Hiltunen (bib0150) 2005; 100 Han, Xu, Kimura, Zheng, Okuda (bib0135) 2000; 130 Stumvoll, Perriello, Meyer, Gerich (bib0115) 1999; 55 Mayr, Chung, Mayr, Yin, Ly, Troy, Fredericks, Hu, Griffiths, Xu (bib0095) 2005; 25 Hong, Rounds, Helton, Robinson, Wilmore (bib0110) 1992; 215 Oliveira, Coelho, Barbeiro, Lima, Soriano, Ribeiro, Molan, Alves, Souza, Machado (bib0105) 2006; 39 Francis, Kerem, Makkar, Becker (bib0140) 2002; 88 Khatri, Johnson, Magid, Lessner, Laude, Dikalov, Harrison, Sung, Rong, Galis (bib0100) 2004; 109 Lee, Hsu, Yen, Chang, Luo, Hsiao, Sheu (bib0045) 2011; 134 Guo, Bei, Hu, Tang, He, Liu, Huang, Cao, Hu, Zhong (bib0030) 2011; 135 Araya, Rodrigo, Videla, Thielemann, Orellana, Pettinelli, Poniachik (bib0125) 2004; 106 Liu, Ning, Shan, Zhang, Deng, Lu, Cheng (bib0165) 2005; 71 Sari, Baltaci, Bagci, Davutoglu, Erel, Celik, Ozer, Aksoy, Aksoy (bib0170) 2010; 26 Chu, Wang, Yao, Li (bib0035) 2010; 16 Martin, Canlet, Delplanque, Agnani, Lairon, Gottardi, Bencharif, Gripois, Thaminy, Paris (bib0060) 2009; 206 Jung, Kim, Lee, Lee, Kim, Park, Kim, Jeong, Choi (bib0160) 2003; 22 Hoa, Cao, Yang (bib0050) 2006; 26 Browning, Horton (bib0075) 2004; 114 Liu, Cheng, Zhang (bib0145) 2004; 52 Nakata, Katsuya, Rakugi, Takami, Sato, Kamide, Ohishi, Miki, Higaki, Ogihara (bib0010) 1997; 10 Li, Wijffels, Yu, Nielsen, Niemeyer, Fisher, Ferguson, Schirra (bib0055) 2011; 10 Teul, Rupére, Garcia, Vaysse, Balaysac, Gilard, Malet-Martino, Martin-Ventura, Blanco-Colio, Tuñón (bib0090) 2009; 8 Murakami, Nakamura, Tanaka, Kawabata, Takahashi, Koshimizu, Ohigashi (bib0155) 2000; 21 Bro, Kjeldahl, Smilde, Kiers (bib0070) 2008; 390 Foster, McGarry (bib0085) 1983; 309 Dieterle (bib0065) 2006; 78 Saheki, Terasaki, Tamai, Tsuji (bib0025) 1994; 11 Gao, Wu, Jiao, Chen, Chen, Kaptchuk, Lu, Song, Chen (bib0040) 2010; 16 Saric, Li, Swann, Utzinger, Calvert, Nicholson, Dirnhofer, Dallman, Bictash, Holmes (bib0130) 2010; 9 Lee (10.1016/j.jpba.2013.02.014_bib0045) 2011; 134 Vinaixa (10.1016/j.jpba.2013.02.014_bib0015) 2010; 9 Gao (10.1016/j.jpba.2013.02.014_bib0040) 2010; 16 Oliveira (10.1016/j.jpba.2013.02.014_bib0105) 2006; 39 Han (10.1016/j.jpba.2013.02.014_bib0135) 2000; 130 Shitara (10.1016/j.jpba.2013.02.014_bib0020) 2006; 112 Li (10.1016/j.jpba.2013.02.014_bib0055) 2011; 10 Martin (10.1016/j.jpba.2013.02.014_bib0060) 2009; 206 Sari (10.1016/j.jpba.2013.02.014_bib0170) 2010; 26 Shimizu (10.1016/j.jpba.2013.02.014_bib0175) 2009; 15 Mayr (10.1016/j.jpba.2013.02.014_bib0095) 2005; 25 Saheki (10.1016/j.jpba.2013.02.014_bib0025) 1994; 11 Francis (10.1016/j.jpba.2013.02.014_bib0140) 2002; 88 Stumvoll (10.1016/j.jpba.2013.02.014_bib0115) 1999; 55 Bro (10.1016/j.jpba.2013.02.014_bib0070) 2008; 390 Teul (10.1016/j.jpba.2013.02.014_bib0090) 2009; 8 Dieterle (10.1016/j.jpba.2013.02.014_bib0065) 2006; 78 Hong (10.1016/j.jpba.2013.02.014_bib0110) 1992; 215 Kim (10.1016/j.jpba.2013.02.014_bib0120) 2010; 10 Hou (10.1016/j.jpba.2013.02.014_bib0150) 2005; 100 Murakami (10.1016/j.jpba.2013.02.014_bib0155) 2000; 21 Liu (10.1016/j.jpba.2013.02.014_bib0165) 2005; 71 Choudhary (10.1016/j.jpba.2013.02.014_bib0005) 2005; 98 Nakata (10.1016/j.jpba.2013.02.014_bib0010) 1997; 10 Jang (10.1016/j.jpba.2013.02.014_bib0080) 2008; 174 Hoa (10.1016/j.jpba.2013.02.014_bib0050) 2006; 26 Saric (10.1016/j.jpba.2013.02.014_bib0130) 2010; 9 Araya (10.1016/j.jpba.2013.02.014_bib0125) 2004; 106 Guo (10.1016/j.jpba.2013.02.014_bib0030) 2011; 135 Foster (10.1016/j.jpba.2013.02.014_bib0085) 1983; 309 Liu (10.1016/j.jpba.2013.02.014_bib0145) 2004; 52 Jung (10.1016/j.jpba.2013.02.014_bib0160) 2003; 22 Chu (10.1016/j.jpba.2013.02.014_bib0035) 2010; 16 Browning (10.1016/j.jpba.2013.02.014_bib0075) 2004; 114 Khatri (10.1016/j.jpba.2013.02.014_bib0100) 2004; 109 |
| References_xml | – volume: 206 start-page: 127 year: 2009 end-page: 133 ident: bib0060 article-title: H NMR metabonomics can differentiate the early atherogenic effect of dairy products in hyperlipidemic hamsters publication-title: Atherosclerosis – volume: 71 start-page: 808 year: 2005 end-page: 813 ident: bib0165 article-title: Phthalide lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-mediated NF-kappaB activation publication-title: Planta Med. – volume: 22 start-page: 561 year: 2003 end-page: 568 ident: bib0160 article-title: Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects publication-title: Clin. Nutr. – volume: 134 start-page: 824 year: 2011 end-page: 830 ident: bib0045 article-title: Traditional Chinese medicine Xue-Fu-Zhu-Yu decoction, potentiates tissue plasminogen activator against thromboembolic stroke in rats publication-title: J. Ethnopharmacol. – volume: 309 start-page: 159 year: 1983 end-page: 169 ident: bib0085 article-title: The metabolic derangements and treatment of diabetic ketoacidosis publication-title: N. Engl. J. Med. Overseas Ed. – volume: 109 start-page: 520 year: 2004 end-page: 525 ident: bib0100 article-title: Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma publication-title: Circulation – volume: 21 start-page: 1843 year: 2000 end-page: 1850 ident: bib0155 article-title: Suppression by citrus auraptene of phorbol ester- and endotoxin-induced inflammatory responses: role of attenuation of leukocyte activation publication-title: Carcinogenesis – volume: 9 start-page: 2255 year: 2010 end-page: 2264 ident: bib0130 article-title: Integrated cytokine and metabolic analysis of pathological responses to parasite exposure in rodents publication-title: J. Proteome Res. – volume: 130 start-page: 2760 year: 2000 end-page: 2764 ident: bib0135 article-title: Platycodi radix affects lipid metabolism in mice with high fat diet–induced obesity publication-title: J. Nutr. – volume: 10 start-page: 1391 year: 1997 end-page: 1395 ident: bib0010 article-title: Polymorphism of angiotensin converting enzyme angiotensinogen, and apolipoprotein E genes in a Japanese population with cerebrovascular disease publication-title: Am. J. Hypertens. – volume: 135 start-page: 299 year: 2011 end-page: 307 ident: bib0030 article-title: A new TCM formula FTZ lowers serum cholesterol by regulating HMG-CoA reductase and CYP7A1 in hyperlipidemic rats publication-title: J. Ethnopharmacol. – volume: 78 start-page: 4281 year: 2006 end-page: 4290 ident: bib0065 article-title: Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures application in publication-title: Anal. Chem. – volume: 8 start-page: 5580 year: 2009 end-page: 5589 ident: bib0090 article-title: Improving metabolite knowledge in stable atherosclerosis patients by association and correlation of GC–MS and publication-title: J. Proteome Res. – volume: 52 start-page: 1295 year: 2004 end-page: 1301 ident: bib0145 article-title: Phytochemical analysis of anti-atherogenic constituents of Xue-Fu-Zhu-Yu-Tang using HPLC-DAD-ESI-MS publication-title: Chem. Pharm. Bull. – volume: 9 start-page: 2527 year: 2010 end-page: 2538 ident: bib0015 article-title: Metabolomic assessment of the effect of dietary cholesterol in the progressive development of fatty liver disease publication-title: J. Proteome Res. – volume: 55 start-page: 778 year: 1999 end-page: 792 ident: bib0115 article-title: Role of glutamine in human carbohydrate metabolism in kidney and other tissues publication-title: Kidney Int. – volume: 100 start-page: 140 year: 2005 end-page: 144 ident: bib0150 article-title: Inhibition of rat vascular smooth muscle cell proliferation by extract of publication-title: J. Ethnopharmacol. – volume: 98 start-page: 217 year: 2005 end-page: 220 ident: bib0005 article-title: Effects of ethanolic extract of Iris Germanica on lipid profile of rats fed on a high-fat diet publication-title: J. Ethnopharmacol. – volume: 174 start-page: 109 year: 2008 end-page: 117 ident: bib0080 article-title: Comparison of hypolipidemic activity of synthetic gallic acid–linoleic acid ester with mixture of gallic acid and linoleic acid gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice publication-title: Chem. Biol. Interact. – volume: 39 start-page: 189 year: 2006 end-page: 194 ident: bib0105 article-title: Liver mitochondrial dysfunction and oxidative stress in the pathogenesis of experimental nonalcoholic fatty liver disease publication-title: Braz. J. Med. Biol. Res. – volume: 16 start-page: 399 year: 2010 end-page: 405 ident: bib0035 article-title: Effect of Xuefu Zhuyu capsule on the symptoms and signs and health-related quality of life in the unstable angina patients with blood-stasis syndrome after percutaneous coronary intervention: a randomized controlled trial publication-title: Chin. J. Integr. Med. – volume: 390 start-page: 1241 year: 2008 end-page: 1251 ident: bib0070 article-title: Cross-validation of component models: a critical look at current methods publication-title: Anal. Bioanal. Chem. – volume: 11 start-page: 305 year: 1994 end-page: 311 ident: bib0025 article-title: In vivo and in vitro blood–brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors publication-title: Pharm. Res. – volume: 114 start-page: 147 year: 2004 end-page: 152 ident: bib0075 article-title: Molecular mediators of hepatic steatosis and liver injury publication-title: J. Clin. Invest. – volume: 10 start-page: 722 year: 2010 end-page: 731 ident: bib0120 article-title: Metabolomic analysis of livers and serum from high-fat diet induced obese mice publication-title: J. Proteome Res. – volume: 26 start-page: 399 year: 2010 end-page: 404 ident: bib0170 article-title: Effect of pistachio diet on lipid parameters, endothelial function, inflammation, and oxidative status: a prospective study publication-title: Nutrition – volume: 16 start-page: 50 year: 2010 end-page: 53 ident: bib0040 article-title: The effect of Xuefu Zhuyu decoction on in vitro endothelial progenitor cell tube formation publication-title: Chin. J. Integr. Med. – volume: 10 start-page: 1073 year: 2011 end-page: 1087 ident: bib0055 article-title: Altered fatty acid metabolism in long duration road transport: an NMR-based metabonomics study in sheep publication-title: J. Proteome Res. – volume: 25 start-page: 2135 year: 2005 end-page: 2142 ident: bib0095 article-title: Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation oxidative stress, and energy metabolism publication-title: Arter. Thromb. Vasc. Biol. – volume: 88 start-page: 587 year: 2002 end-page: 605 ident: bib0140 article-title: The biological action of saponins in animal systems: a review publication-title: Br. J. Nutr. – volume: 15 start-page: 3068 year: 2009 end-page: 3075 ident: bib0175 article-title: Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice publication-title: Clin. Cancer Res. – volume: 26 start-page: 125 year: 2006 end-page: 127 ident: bib0050 article-title: Intervention of Xuefu Zhuyu oral liquid on expression of adhesion molecule CDllb/CD18 in neutrophils in patients with arteriosclerosis obliterans publication-title: Chin. J. Integr. Med. – volume: 106 start-page: 635 year: 2004 end-page: 643 ident: bib0125 article-title: Increase in long-chain polyunsaturated fatty acid publication-title: Clin. Sci. – volume: 112 start-page: 71 year: 2006 end-page: 105 ident: bib0020 article-title: Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug–drug interactions and interindividual differences in transporter and metabolic enzyme functions publication-title: Pharmacol. Ther. – volume: 215 start-page: 114 year: 1992 end-page: 119 ident: bib0110 article-title: Glutamine preserves liver glutathione after lethal hepatic injury publication-title: Ann. Surg. – volume: 26 start-page: 125 year: 2006 ident: 10.1016/j.jpba.2013.02.014_bib0050 article-title: Intervention of Xuefu Zhuyu oral liquid on expression of adhesion molecule CDllb/CD18 in neutrophils in patients with arteriosclerosis obliterans publication-title: Chin. J. Integr. Med. – volume: 16 start-page: 50 year: 2010 ident: 10.1016/j.jpba.2013.02.014_bib0040 article-title: The effect of Xuefu Zhuyu decoction on in vitro endothelial progenitor cell tube formation publication-title: Chin. J. Integr. Med. doi: 10.1007/s11655-010-0050-y – volume: 52 start-page: 1295 year: 2004 ident: 10.1016/j.jpba.2013.02.014_bib0145 article-title: Phytochemical analysis of anti-atherogenic constituents of Xue-Fu-Zhu-Yu-Tang using HPLC-DAD-ESI-MS publication-title: Chem. Pharm. Bull. doi: 10.1248/cpb.52.1295 – volume: 390 start-page: 1241 year: 2008 ident: 10.1016/j.jpba.2013.02.014_bib0070 article-title: Cross-validation of component models: a critical look at current methods publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-007-1790-1 – volume: 206 start-page: 127 year: 2009 ident: 10.1016/j.jpba.2013.02.014_bib0060 article-title: 1H NMR metabonomics can differentiate the early atherogenic effect of dairy products in hyperlipidemic hamsters publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2009.01.040 – volume: 134 start-page: 824 year: 2011 ident: 10.1016/j.jpba.2013.02.014_bib0045 article-title: Traditional Chinese medicine Xue-Fu-Zhu-Yu decoction, potentiates tissue plasminogen activator against thromboembolic stroke in rats publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2011.01.033 – volume: 174 start-page: 109 year: 2008 ident: 10.1016/j.jpba.2013.02.014_bib0080 article-title: Comparison of hypolipidemic activity of synthetic gallic acid–linoleic acid ester with mixture of gallic acid and linoleic acid gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice publication-title: Chem. Biol. Interact. doi: 10.1016/j.cbi.2008.05.018 – volume: 109 start-page: 520 year: 2004 ident: 10.1016/j.jpba.2013.02.014_bib0100 article-title: Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma publication-title: Circulation doi: 10.1161/01.CIR.0000109698.70638.2B – volume: 25 start-page: 2135 year: 2005 ident: 10.1016/j.jpba.2013.02.014_bib0095 article-title: Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation oxidative stress, and energy metabolism publication-title: Arter. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.0000183928.25844.f6 – volume: 39 start-page: 189 year: 2006 ident: 10.1016/j.jpba.2013.02.014_bib0105 article-title: Liver mitochondrial dysfunction and oxidative stress in the pathogenesis of experimental nonalcoholic fatty liver disease publication-title: Braz. J. Med. Biol. Res. doi: 10.1590/S0100-879X2006000200004 – volume: 309 start-page: 159 year: 1983 ident: 10.1016/j.jpba.2013.02.014_bib0085 article-title: The metabolic derangements and treatment of diabetic ketoacidosis publication-title: N. Engl. J. Med. Overseas Ed. doi: 10.1056/NEJM198307213090307 – volume: 100 start-page: 140 year: 2005 ident: 10.1016/j.jpba.2013.02.014_bib0150 article-title: Inhibition of rat vascular smooth muscle cell proliferation by extract of Ligusticum chuanxiong and Angelica sinensis publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2005.01.051 – volume: 114 start-page: 147 year: 2004 ident: 10.1016/j.jpba.2013.02.014_bib0075 article-title: Molecular mediators of hepatic steatosis and liver injury publication-title: J. Clin. Invest. doi: 10.1172/JCI200422422 – volume: 16 start-page: 399 year: 2010 ident: 10.1016/j.jpba.2013.02.014_bib0035 article-title: Effect of Xuefu Zhuyu capsule on the symptoms and signs and health-related quality of life in the unstable angina patients with blood-stasis syndrome after percutaneous coronary intervention: a randomized controlled trial publication-title: Chin. J. Integr. Med. doi: 10.1007/s11655-010-9999-9 – volume: 112 start-page: 71 year: 2006 ident: 10.1016/j.jpba.2013.02.014_bib0020 article-title: Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug–drug interactions and interindividual differences in transporter and metabolic enzyme functions publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2006.03.003 – volume: 130 start-page: 2760 year: 2000 ident: 10.1016/j.jpba.2013.02.014_bib0135 article-title: Platycodi radix affects lipid metabolism in mice with high fat diet–induced obesity publication-title: J. Nutr. doi: 10.1093/jn/130.11.2760 – volume: 11 start-page: 305 year: 1994 ident: 10.1016/j.jpba.2013.02.014_bib0025 article-title: In vivo and in vitro blood–brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors publication-title: Pharm. Res. doi: 10.1023/A:1018975928974 – volume: 21 start-page: 1843 year: 2000 ident: 10.1016/j.jpba.2013.02.014_bib0155 article-title: Suppression by citrus auraptene of phorbol ester- and endotoxin-induced inflammatory responses: role of attenuation of leukocyte activation publication-title: Carcinogenesis doi: 10.1093/carcin/21.10.1843 – volume: 88 start-page: 587 year: 2002 ident: 10.1016/j.jpba.2013.02.014_bib0140 article-title: The biological action of saponins in animal systems: a review publication-title: Br. J. Nutr. doi: 10.1079/BJN2002725 – volume: 26 start-page: 399 year: 2010 ident: 10.1016/j.jpba.2013.02.014_bib0170 article-title: Effect of pistachio diet on lipid parameters, endothelial function, inflammation, and oxidative status: a prospective study publication-title: Nutrition doi: 10.1016/j.nut.2009.05.023 – volume: 98 start-page: 217 year: 2005 ident: 10.1016/j.jpba.2013.02.014_bib0005 article-title: Effects of ethanolic extract of Iris Germanica on lipid profile of rats fed on a high-fat diet publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2005.01.013 – volume: 78 start-page: 4281 year: 2006 ident: 10.1016/j.jpba.2013.02.014_bib0065 article-title: Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures application in 1H NMR metabonomics publication-title: Anal. Chem. doi: 10.1021/ac051632c – volume: 135 start-page: 299 year: 2011 ident: 10.1016/j.jpba.2013.02.014_bib0030 article-title: A new TCM formula FTZ lowers serum cholesterol by regulating HMG-CoA reductase and CYP7A1 in hyperlipidemic rats publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2011.03.012 – volume: 55 start-page: 778 year: 1999 ident: 10.1016/j.jpba.2013.02.014_bib0115 article-title: Role of glutamine in human carbohydrate metabolism in kidney and other tissues publication-title: Kidney Int. doi: 10.1046/j.1523-1755.1999.055003778.x – volume: 106 start-page: 635 year: 2004 ident: 10.1016/j.jpba.2013.02.014_bib0125 article-title: Increase in long-chain polyunsaturated fatty acid n−6/n−3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease publication-title: Clin. Sci. doi: 10.1042/CS20030326 – volume: 10 start-page: 722 year: 2010 ident: 10.1016/j.jpba.2013.02.014_bib0120 article-title: Metabolomic analysis of livers and serum from high-fat diet induced obese mice publication-title: J. Proteome Res. doi: 10.1021/pr100892r – volume: 22 start-page: 561 year: 2003 ident: 10.1016/j.jpba.2013.02.014_bib0160 article-title: Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects publication-title: Clin. Nutr. doi: 10.1016/S0261-5614(03)00059-1 – volume: 10 start-page: 1073 year: 2011 ident: 10.1016/j.jpba.2013.02.014_bib0055 article-title: Altered fatty acid metabolism in long duration road transport: an NMR-based metabonomics study in sheep publication-title: J. Proteome Res. doi: 10.1021/pr100862t – volume: 15 start-page: 3068 year: 2009 ident: 10.1016/j.jpba.2013.02.014_bib0175 article-title: Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-08-2093 – volume: 8 start-page: 5580 year: 2009 ident: 10.1016/j.jpba.2013.02.014_bib0090 article-title: Improving metabolite knowledge in stable atherosclerosis patients by association and correlation of GC–MS and 1H NMR fingerprints publication-title: J. Proteome Res. doi: 10.1021/pr900668v – volume: 9 start-page: 2527 year: 2010 ident: 10.1016/j.jpba.2013.02.014_bib0015 article-title: Metabolomic assessment of the effect of dietary cholesterol in the progressive development of fatty liver disease publication-title: J. Proteome Res. doi: 10.1021/pr901203w – volume: 9 start-page: 2255 year: 2010 ident: 10.1016/j.jpba.2013.02.014_bib0130 article-title: Integrated cytokine and metabolic analysis of pathological responses to parasite exposure in rodents publication-title: J. Proteome Res. doi: 10.1021/pr901019z – volume: 10 start-page: 1391 year: 1997 ident: 10.1016/j.jpba.2013.02.014_bib0010 article-title: Polymorphism of angiotensin converting enzyme angiotensinogen, and apolipoprotein E genes in a Japanese population with cerebrovascular disease publication-title: Am. J. Hypertens. doi: 10.1016/S0895-7061(97)00315-4 – volume: 71 start-page: 808 year: 2005 ident: 10.1016/j.jpba.2013.02.014_bib0165 article-title: Phthalide lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-mediated NF-kappaB activation publication-title: Planta Med. doi: 10.1055/s-2005-871231 – volume: 215 start-page: 114 year: 1992 ident: 10.1016/j.jpba.2013.02.014_bib0110 article-title: Glutamine preserves liver glutathione after lethal hepatic injury publication-title: Ann. Surg. doi: 10.1097/00000658-199202000-00004 |
| SSID | ssj0005194 |
| Score | 2.374273 |
| Snippet | [Display omitted]
► Effect of XFZYD on hyperlipidemia rats were investigated by NMR-based metabolomics. ► Seventeen marker metabolites were indentified to be... |
| SourceID | crossref elsevier |
| SourceType | Enrichment Source Index Database Publisher |
| StartPage | 202 |
| SubjectTerms | 1H NMR spectroscopy Hyperlipidemia Metabolomics OPLS-DA Traditional Chinese medicines Xue-Fu-Zhu-Yu decoction |
| Title | 1H NMR-based metabolomics approach to evaluate the effect of Xue-Fu-Zhu-Yu decoction on hyperlipidemia rats induced by high-fat diet |
| URI | https://dx.doi.org/10.1016/j.jpba.2013.02.014 |
| Volume | 78-79 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LSwMxEA6lXryIT3yWOYgXje1mH-kepViq0iJaoXpZkk1CW2pb7O6hF0_-cCf70AriQchhWTKwZIbM97Ez3xBy6nOluQo59QVHgiLxCZMCox43omkahrvG_tHt9oLOk3c78AcV0ip7YWxZZXH353d6dlsXb-rFadbno1H9EYPT4RYxuFkitI3mnsdtlF--r5R5ONkwRLuZ2t1F40xe4zWeS6s95LiZbqfj_Z6cVhJOe5NsFEgRrvKP2SIVPd0mZ_e51PTyAvrfnVOLCziD-28R6uUO-XA60Os-UJulFLzqBJ09sR3ICyhlxCGZQSH2rQFxIOS1HTAzMEg1baf0ZZjS5xQUUtSs_QFwDZG4vk1G-WBZARhAC0BejxGiQC7Byh9TIxJQI53skqf2db_VocXEBRqzMEioGwdx7AXGWJU4JWQjaKiQcdEMY2ZME6ElMx5SOM00AgUhjXZDgRRLMuUHXAt3j1Sns6neJyA9NJKsqUONjMvViDONNoiHTMxlyNQBccqjjuJCjtxOxZhEZd3ZOLLuiax7ogaL0D0H5PzLZp6Lcfy52y89GP0IqQizxR92h_-0OyLrLJuV4eM6JtXkLdUniFgSWctCskbWrm7uOr1PzV7rvw |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NaxsxEB1S59BeSvpF06btHEoujbBX-yHvMYSaTROb0Drg9iKklUQcHNvEuwff-8M72tXWLZQcCjosiwYWzaB5j515A_AxFcYKkwuWKkEERdMTJQXOEuHU0A2ciJ3_ozueZMV18mWWzvbgrOuF8WWV4e5v7_Tmtg5v-uE0--v5vP-NgjMSHjHETSJMH8G-V6dKe7B_en5RTHaVHlEzD9HvZ94g9M60ZV63a-3lh6K4ke6Mkn_npz9yzugAngawiKft9zyDPbt8DsdXrdr09gSnu-apzQke49VOh3r7An5GBU7GX5lPVAbvbEX-Xvgm5A12SuJYrTDofVskKIhteQeuHM5qy0Y1-3FTs-81GmKpTQcE0roh7nq_mLezZRVSDG2QqD0FiUG9Ra-AzJyq0Mxt9RKuR5-nZwULQxdYyfOsYnGZlWWSOeeF4ozSg2xgci7UMC-5c0NCl9wlxOIst4QVlHY2zhWxLM1Nmgmr4lfQW66W9jWgTshI86HNLZGu2BLUdNYRJHKl0Dk3hxB1Ry3LoEjuB2MsZFd6diu9e6R3jxxwSe45hE-_bdatHseDu9POg_KvqJKUMB6we_Ofdh_gcTEdX8rL88nFW3jCm9EZKa0j6FX3tX1HAKbS70OA_gLip-5w |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=1H+NMR-based+metabolomics+approach+to+evaluate+the+effect+of+Xue-Fu-Zhu-Yu+decoction+on+hyperlipidemia+rats+induced+by+high-fat+diet&rft.jtitle=Journal+of+pharmaceutical+and+biomedical+analysis&rft.au=Song%2C+Xingfang&rft.au=Wang%2C+Junsong&rft.au=Wang%2C+Pengran&rft.au=Tian%2C+Na&rft.date=2013-05-05&rft.pub=Elsevier+B.V&rft.issn=0731-7085&rft.eissn=1873-264X&rft.volume=78-79&rft.spage=202&rft.epage=210&rft_id=info:doi/10.1016%2Fj.jpba.2013.02.014&rft.externalDocID=S0731708513000745 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0731-7085&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0731-7085&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0731-7085&client=summon |