Rheumatoid arthritis in southern Spain: Toward elucidation of a unifying role of the HLA class II region in disease predisposition

• Published in: Arthritis and rheumatism Vol. 44; no. 2; pp. 307 - 314
• Main Authors: Pascual, M., Nieto, A., López‐Nevot, M. A., Ramal, L., Matarán, L., Caballero, A., Alonso, A., Martín, J., Zanelli, E.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.02.2001; Wiley
• Subjects: Alleles; Arthritis, Rheumatoid - epidemiology; Arthritis, Rheumatoid - genetics; Biological and medical sciences; Diseases of the osteoarticular system; Female; Genetic Predisposition to Disease; Histocompatibility Antigens Class II - genetics; HLA-DQ Antigens - genetics; HLA-DR Antigens - genetics; HLA-DR Serological Subtypes; HLA-DR1 Antigen - genetics; HLA-DR4 Antigen - genetics; Humans; Inflammatory joint diseases; Linkage Disequilibrium; Male; Medical sciences; Middle Aged; Spain - epidemiology; Europe; Spain; Human; Immunopathology; HLA-System; Pathogenesis; Diseases of the osteoarticular system; Class II histocompatibility antigen; Autoimmune disease; Exploration; Inflammatory joint disease; Genetic determinism; Epidemiology; Symptomatology; Chronic; DNA; Rheumatoid arthritis; Public health; Polymorphism

Objective To evaluate the contributions of HLA–DQ and –DR polymorphisms to susceptibility to rheumatoid arthritis (RA) in a population in southern Spain, and to compare the value of the shared epitope (SE) and RA protection (RAP) models in accounting for the HLA class II region's contribution t...