Nimbolide Induces Cell Apoptosis via Mediating ER Stress‐Regulated Apoptotic Signaling in Human Oral Squamous Cell Carcinoma

• Published in: Environmental toxicology Vol. 40; no. 2; pp. 347 - 356
• Main Authors: Peng, Bou‐Yue, Wu, Chia‐Yu, Lee, Chia‐Jung, Chang, Tsung‐Ming, Tsao, Ya‐Ting, Liu, Ju‐Fang
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.02.2025; Wiley Subscription Services, Inc
• Subjects: Annexin V; Antineoplastic Agents - pharmacology; antitumor agent; Apoptosis; Apoptosis - drug effects; Asia; Calcium; Calcium (intracellular); Calcium (mitochondrial); Calcium (reticular); Calcium compounds; Cancer; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - metabolism; Caspase; caspases; Cell cycle; Cell growth; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Cell survival; ecotoxicology; Endoplasmic reticulum; endoplasmic reticulum stress; Endoplasmic Reticulum Stress - drug effects; ER stress; Flow cytometry; human oral squamous cell carcinoma; Humans; Limonins - pharmacology; Membrane potential; Membrane Potential, Mitochondrial - drug effects; Mitochondria; mitochondrial membrane; Mouth Neoplasms - drug therapy; Mouth Neoplasms - metabolism; neoplasm cells; Neoplasms; nimbolide; Oral cancer; Oral carcinoma; Oral squamous cell carcinoma; Protein expression; protein synthesis; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; ROS; Signal Transduction - drug effects; Squamous cell carcinoma; therapeutics; Tumor cells; Tumors; viability; Western blotting; Asia; ER stress; antitumor agent; apoptosis; nimbolide; human oral squamous cell carcinoma; ROS

ABSTRACT Human oral squamous cell carcinoma (OSCC) poses a significant health challenge in Asia, with current therapeutic strategies failing to improve the survival rates for OSCC patients sufficiently. To elucidate the effects of Nimbolide on OSCC cell proliferation and apoptosis, we performed a se...