Importance of oral dosing rate on the hemodynamic and pharmacokinetic profile on nilvadipine

• Published in: Journal of clinical pharmacology Vol. 28; no. 11; p. 1001
• Main Authors: Cheung, W K, Sia, L L, Woodward, D L, Graveline, J F, Desjardins, R E, Yacobi, A, Silber, B M
• Format: Journal Article
• Language: English
• Published: England 01.11.1988
• Subjects: Adult; Blood Pressure - drug effects; Calcium Channel Blockers - administration & dosage; Calcium Channel Blockers - pharmacokinetics; Calcium Channel Blockers - pharmacology; Heart Rate - drug effects; Hemodynamics - drug effects; Humans; Male; Nifedipine - administration & dosage; Nifedipine - analogs & derivatives; Nifedipine - pharmacokinetics; Nifedipine - pharmacology

Nilvadipine was administered as an oral solution formulation to 12 normotensive subjects in a three-way randomized crossover study at a dose of 16 mg as three different dosing regimens: 1) as a single 16 mg dose, 2) as a 1.6 mg dose given hourly for 10 doses, and 3) as an initial dose of 4.8 mg, fol...