Differential kinetics of human cytomegalovirus load and antibody responses in primary infection of the immunocompetent and immunocompromised host

• Published in: Journal of general virology Vol. 96; no. 2; pp. 360 - 369
• Main Authors: Gerna, Giuseppe, Lilleri, Daniele, Fornara, Chiara, Bruno, Francesca, Gabanti, Elisa, Cane, Ilaria, Furione, Milena, Revello, M. Grazia
• Format: Journal Article
• Language: English
• Published: England 01.02.2015
• Subjects: Adult; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Antibody Formation; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Cytomegalovirus - immunology; Cytomegalovirus - isolation & purification; Cytomegalovirus Infections - immunology; Cytomegalovirus Infections - virology; DNA, Viral - blood; Female; Humans; Immunocompromised Host; Immunoglobulin G - blood; Male; Pregnancy; Time Factors; Transplant Recipients; Viral Load; Viral Proteins - immunology; Young Adult

The comparative long-term kinetics of human cytomegalovirus (HCMV) load and HCMV-specific antibody responses in the immunocompetent and immunocompromised solid-organ transplanted host during primary HCMV infection was investigated. In total, 40 immunocompetent subjects and 17 transplanted patients w...