Lower levels of senescence in human lung mesenchymal stromal cells compared with lung fibroblasts: implications for tissue regeneration in COPD

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 328; no. 6; pp. L858 - L865
• Main Authors: Wisman, Marissa, Kruk, Dennis M. L. W., Kooistra, Wierd, Heijink, Irene H., Woldhuis, Roy R.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.06.2025
• Subjects: Aged; Alveoli; beta-Galactosidase - metabolism; Cell culture; Cell Proliferation; Cells, Cultured; Cellular Senescence; Chronic obstructive pulmonary disease; Cyclin-dependent kinase inhibitor p21; Female; Fibroblast growth factor 10; Fibroblasts; Fibroblasts - metabolism; Fibroblasts - pathology; Galactosidase; Growth factors; GTP-binding protein; Hepatocyte growth factor; Hepatocyte Growth Factor - metabolism; Humans; Interleukin 6; Interleukin 8; Interleukin-6 - metabolism; Lung - cytology; Lung - metabolism; Lung - pathology; Lung diseases; Lungs; Male; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Mesenchymal Stem Cells - pathology; Middle Aged; Paraquat; Physiology; Proteins; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - pathology; Regeneration; Regeneration (physiology); Senescence; Sensitivity; Stromal cells; Tissue engineering; β-Galactosidase; senescence; tissue regeneration; lung mesenchymal stromal cells; COPD

We demonstrate that LMSCs are less sensitive to senescence induction by oxidative stress and replication than LFs, which was accompanied by an increased ability to expand. This makes LMSCs more suitable for cell-based therapies in COPD. As senescence affected growth factors involved in alveolar repa...