Lower levels of senescence in human lung mesenchymal stromal cells compared with lung fibroblasts: implications for tissue regeneration in COPD - Wisman, Marissa; Kruk, Dennis M. L. W.; Kooistra, Wierd; Heijink, Irene H.; Woldhuis, Roy R. (American journal of physiology. Lung cellular and molecular physiology, 2025)
Keywords: Aged; Alveoli; beta-Galactosidase - metabolism; Cell culture; Cell Proliferation; Cells, Cultured; Cellular Senescence; Chronic obstructive pulmonary disease; Cyclin-dependent kinase inhibitor p21; Female; Fibroblast growth factor 10; Fibroblasts; Fibroblasts - metabolism; Fibroblasts - pathology; Galactosidase; Growth factors; GTP-binding protein; Hepatocyte growth factor; Hepatocyte Growth Factor - metabolism; Humans; Interleukin 6; Interleukin 8; Interleukin-6 - metabolism; Lung - cytology; Lung - metabolism; Lung - pathology; Lung diseases; Lungs; Male; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Mesenchymal Stem Cells - pathology; Middle Aged; Paraquat; Physiology; Proteins; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - pathology; Regeneration; Regeneration (physiology); Senescence; Sensitivity; Stromal cells; Tissue engineering; β-Galactosidase; senescence; tissue regeneration; lung mesenchymal stromal cells; COPD