Metabolomic and secretomic approach to the resistance features of the fungus Aspergillus niger IOC 4687 to copper stress

Metabolomic and secretomic analyses of Aspergillus niger IOC 4687 indicated the features of resistance of this strain to copper stress. To investigate the metabolites produced under oxidative stress conditions, gas chromatography-mass spectrometry analysis was performed. The secretome principal comp...

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Published inMetallomics Vol. 13; no. 1
Main Authors Perdigão Cota de Almeida, Silas, Rozas, Enrique Eduardo, Oller do Nascimento, Cláudio Augusto, Dias, Meriellen, Mendes, Maria Anita
Format Journal Article
LanguageEnglish
Published England 21.01.2021
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Abstract Metabolomic and secretomic analyses of Aspergillus niger IOC 4687 indicated the features of resistance of this strain to copper stress. To investigate the metabolites produced under oxidative stress conditions, gas chromatography-mass spectrometry analysis was performed. The secretome principal component analysis results showed that mannitol could be the main metabolite responsible for conferring resistance to the fungus, and gluconic acid is the possible cause of copper desorption because of its chelating ability. The meta-analysis of the metabolome of A. niger IOC 4687 indicated that a low concentration of sorbitol and ribonolactone during growth may be an indicator of oxidative stress.
AbstractList Metabolomic and secretomic analyses of Aspergillus niger IOC 4687 indicated the features of resistance of this strain to copper stress. To investigate the metabolites produced under oxidative stress conditions, gas chromatography-mass spectrometry analysis was performed. The secretome principal component analysis results showed that mannitol could be the main metabolite responsible for conferring resistance to the fungus, and gluconic acid is the possible cause of copper desorption because of its chelating ability. The meta-analysis of the metabolome of A. niger IOC 4687 indicated that a low concentration of sorbitol and ribonolactone during growth may be an indicator of oxidative stress.
Author Oller do Nascimento, Cláudio Augusto
Dias, Meriellen
Mendes, Maria Anita
Perdigão Cota de Almeida, Silas
Rozas, Enrique Eduardo
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crossref_primary_10_1016_j_lwt_2023_114631
crossref_primary_10_1016_j_compbiomed_2022_105296
crossref_primary_10_3390_molecules27217365
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