Ectopic lipid deposition and insulin resistance in patients with GH disorders before and after treatment
Insulin resistance is associated with ectopic lipid deposition. Growth hormone (GH) status also modulates ectopic lipid accumulation, but how this associates with insulin resistance in patients with GH disorders is not well established. Twenty-one patients diagnosed with acromegaly and 12 patients w...
Saved in:
| Published in | European journal of endocrinology Vol. 188; no. 1; pp. 78 - 85 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
10.01.2023
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0804-4643 1479-683X 1479-683X |
| DOI | 10.1093/ejendo/lvac014 |
Cover
Loading…
| Abstract | Insulin resistance is associated with ectopic lipid deposition. Growth hormone (GH) status also modulates ectopic lipid accumulation, but how this associates with insulin resistance in patients with GH disorders is not well established.
Twenty-one patients diagnosed with acromegaly and 12 patients with adult GH deficiency (GHD) were studied at diagnosis and after treatment. A reference group of 12 subjects was included. Each study day comprised assessment of body composition with dual-energy X-ray absorptiometry, ectopic lipid deposition in the liver by MR spectroscopy, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR).
Disease control of acromegaly decreased lean body mass (LBM) (P < .000) and increased the percentage of total body fat (TBF) (P < .000). GH replacement increased LBM in the GHD patients (P = .007) and decreased the percentage of TBF (P = .010). The intrahepatic lipid (IHL) content increased after disease control in acromegaly (P = .004), whereas IHL did not change significantly after GH replacement in GHD (P = .34). Insulin resistance (HOMA-IR) improved after disease control of acromegaly (P < .000) and remained unaltered after GH replacement in the GHD patients (P = .829).
GH status is a significant modulator of body composition and insulin sensitivity.GH excess reduces total fat mass and intrahepatic lipid content together with induction of insulin resistance.The data support the notion that GH-induced insulin resistance is unassociated with hepatic lipid accumulation. |
|---|---|
| AbstractList | Insulin resistance is associated with ectopic lipid deposition. Growth hormone (GH) status also modulates ectopic lipid accumulation, but how this associates with insulin resistance in patients with GH disorders is not well established.OBJECTIVESInsulin resistance is associated with ectopic lipid deposition. Growth hormone (GH) status also modulates ectopic lipid accumulation, but how this associates with insulin resistance in patients with GH disorders is not well established.Twenty-one patients diagnosed with acromegaly and 12 patients with adult GH deficiency (GHD) were studied at diagnosis and after treatment. A reference group of 12 subjects was included. Each study day comprised assessment of body composition with dual-energy X-ray absorptiometry, ectopic lipid deposition in the liver by MR spectroscopy, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR).DESIGN AND METHODSTwenty-one patients diagnosed with acromegaly and 12 patients with adult GH deficiency (GHD) were studied at diagnosis and after treatment. A reference group of 12 subjects was included. Each study day comprised assessment of body composition with dual-energy X-ray absorptiometry, ectopic lipid deposition in the liver by MR spectroscopy, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR).Disease control of acromegaly decreased lean body mass (LBM) (P < .000) and increased the percentage of total body fat (TBF) (P < .000). GH replacement increased LBM in the GHD patients (P = .007) and decreased the percentage of TBF (P = .010). The intrahepatic lipid (IHL) content increased after disease control in acromegaly (P = .004), whereas IHL did not change significantly after GH replacement in GHD (P = .34). Insulin resistance (HOMA-IR) improved after disease control of acromegaly (P < .000) and remained unaltered after GH replacement in the GHD patients (P = .829).RESULTSDisease control of acromegaly decreased lean body mass (LBM) (P < .000) and increased the percentage of total body fat (TBF) (P < .000). GH replacement increased LBM in the GHD patients (P = .007) and decreased the percentage of TBF (P = .010). The intrahepatic lipid (IHL) content increased after disease control in acromegaly (P = .004), whereas IHL did not change significantly after GH replacement in GHD (P = .34). Insulin resistance (HOMA-IR) improved after disease control of acromegaly (P < .000) and remained unaltered after GH replacement in the GHD patients (P = .829).GH status is a significant modulator of body composition and insulin sensitivity.GH excess reduces total fat mass and intrahepatic lipid content together with induction of insulin resistance.The data support the notion that GH-induced insulin resistance is unassociated with hepatic lipid accumulation.CONCLUSIONSGH status is a significant modulator of body composition and insulin sensitivity.GH excess reduces total fat mass and intrahepatic lipid content together with induction of insulin resistance.The data support the notion that GH-induced insulin resistance is unassociated with hepatic lipid accumulation. Insulin resistance is associated with ectopic lipid deposition. Growth hormone (GH) status also modulates ectopic lipid accumulation, but how this associates with insulin resistance in patients with GH disorders is not well established. Twenty-one patients diagnosed with acromegaly and 12 patients with adult GH deficiency (GHD) were studied at diagnosis and after treatment. A reference group of 12 subjects was included. Each study day comprised assessment of body composition with dual-energy X-ray absorptiometry, ectopic lipid deposition in the liver by MR spectroscopy, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Disease control of acromegaly decreased lean body mass (LBM) (P < .000) and increased the percentage of total body fat (TBF) (P < .000). GH replacement increased LBM in the GHD patients (P = .007) and decreased the percentage of TBF (P = .010). The intrahepatic lipid (IHL) content increased after disease control in acromegaly (P = .004), whereas IHL did not change significantly after GH replacement in GHD (P = .34). Insulin resistance (HOMA-IR) improved after disease control of acromegaly (P < .000) and remained unaltered after GH replacement in the GHD patients (P = .829). GH status is a significant modulator of body composition and insulin sensitivity.GH excess reduces total fat mass and intrahepatic lipid content together with induction of insulin resistance.The data support the notion that GH-induced insulin resistance is unassociated with hepatic lipid accumulation. |
| Author | Ringgaard, Steffen Høgild, Morten Arlien-Søborg, Mai C Dal, Jakob Skou, Nickolaj Jørgensen, Jens Otto Lunde Madsen, Michael Alle Krusenstjerna-Hafstrøm, Thomas |
| Author_xml | – sequence: 1 givenname: Mai C orcidid: 0000-0001-8424-558X surname: Arlien-Søborg fullname: Arlien-Søborg, Mai C – sequence: 2 givenname: Michael Alle surname: Madsen fullname: Madsen, Michael Alle – sequence: 3 givenname: Jakob surname: Dal fullname: Dal, Jakob – sequence: 4 givenname: Thomas surname: Krusenstjerna-Hafstrøm fullname: Krusenstjerna-Hafstrøm, Thomas – sequence: 5 givenname: Steffen surname: Ringgaard fullname: Ringgaard, Steffen – sequence: 6 givenname: Nickolaj surname: Skou fullname: Skou, Nickolaj – sequence: 7 givenname: Morten orcidid: 0000-0002-2442-6992 surname: Høgild fullname: Høgild, Morten – sequence: 8 givenname: Jens Otto Lunde surname: Jørgensen fullname: Jørgensen, Jens Otto Lunde |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36651164$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kUtLAzEUhYNU7EO3LiVLN9NmJvNcSqmtILhRcBcyyQ1NmUnGJFX896a23Qiubm74zoF7zhSNjDWA0G1K5ilp6AJ2YKRddJ9ckDS_QJM0r5qkrOn7CE1ITfIkL3M6RlPvd4Sk8U2u0JiWZZHGZYK2KxHsoAXu9KAlljBYr4O2BnMjsTZ-32mDHXjtAzcC4hceeNBggsdfOmzxeoOl9tZJcB63oKyDXy1XARwODnjoI32NLhXvPNyc5gy9Pa5el5vk-WX9tHx4TkTWFCGpogMvaKkaWhDC63iJVE3WFqKslKKkESm0mcybTELLBc0yQVVbK8lzVVEo6AzdH30HZz_24APrtRfQddyA3XuWVWVZZYdkInp3QvdtD5INTvfcfbNzOhHIj4Bw1nsHigkd-CGd4LjuWErYoQR2LIGdSoiy-R_Z2fkfwQ9GNY8f |
| CitedBy_id | crossref_primary_10_1210_jendso_bvad028 crossref_primary_10_1093_ejendo_lvae016 crossref_primary_10_3390_medicina60081241 crossref_primary_10_1007_s40618_024_02384_5 crossref_primary_10_1210_clinem_dgad490 |
| Cites_doi | 10.1093/ajcn/71.4.885 10.1210/jc.2014-1532 10.1146/annurev.ph.54.030192.002323 10.2337/diacare.27.6.1487 10.1530/EJE-10-0969 10.2337/db17-0524 10.1210/er.2008-0009 10.1210/clinem/dgac405 10.1210/en.2010-0537 10.1007/s12020-018-1742-x 10.1210/jc.2009-0438 10.1074/jbc.M109.014308 10.1253/circj.68.975 10.1136/gut.52.6.914 10.3390/biomedicines8090298 10.1111/cen.13042 10.1210/clinem/dgac088 10.1016/j.cccn.2004.09.022 10.1038/ncpendmet0190 10.1152/ajpendo.00117.2003 10.1530/EJE-19-0139 10.1016/j.cyto.2016.06.028 10.1210/jendso/bvab004 10.1210/jc.2015-1917 10.1016/j.ebiom.2021.103763 10.1038/oby.2008.487 10.1210/er.2008-0027 10.1046/j.1365-2265.1996.8720883.x 10.1530/EJE-12-0002 10.1016/j.cell.2012.02.017 10.1038/90984 10.2337/db16-0649 10.1161/01.ATV.20.6.1595 10.1210/jcem.86.12.8075 10.1016/j.metabol.2012.05.019 10.1016/j.transproceed.2015.10.068 10.1172/JCI113451 10.1016/j.tem.2016.02.005 10.1152/ajpendo.00374.2006 10.1023/B:REMD.0000021434.98627.dc 10.1016/j.ghir.2022.101482 10.1042/CS20070217 10.1053/j.gastro.2006.12.024 10.1155/2018/4125013 10.1007/s11892-008-0032-z 10.1210/jc.2003-032023 10.3389/fendo.2019.00509 10.1016/j.diabet.2008.01.014 10.1210/jc.2013-3059 10.1210/jc.2017-01210 10.2337/diabetes.53.12.3048 10.1152/ajpendo.00279.2003 10.1210/jc.2011-2681 10.1530/JOE-20-0326 10.1210/endo.141.1.7263 10.1530/EJE-17-0546 10.1210/clinem/dgz033 10.1210/jc.2007-2780 10.1210/jc.2016-1806 10.1210/jc.2014-2242 10.1172/jci.insight.134638 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2023. Published by Oxford University Press on behalf of (ESE) European Society of Endocrinology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
| Copyright_xml | – notice: The Author(s) 2023. Published by Oxford University Press on behalf of (ESE) European Society of Endocrinology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1093/ejendo/lvac014 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1479-683X |
| EndPage | 85 |
| ExternalDocumentID | 36651164 10_1093_ejendo_lvac014 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: Independent Research Fund Denmark grantid: 7016-00303A |
| GroupedDBID | --- -~X 0R~ 18M 2WC 4.4 5GY 5RE 5VS 5WD AABZA AACZT AAPXW AARHZ AAUAY AAVAP AAYXX ABDFA ABEJV ABGNP ABJNI ABMNT ABNHQ ABOCM ABPQP ABPTD ABQNK ABSQV ABVGC ABWST ABXVV ABXZS ACGFO ACNCT ACPRK ACUTJ ADBBV ADGKP ADIPN ADNBA ADQBN ADVEK ADVOB AEMQT AENEX AFGWE AFHIN AFXAL AGORE AGQXC AGUTN AHGBF AHMMS AJBYB AJEEA AJNCP ALMA_UNASSIGNED_HOLDINGS ALXQX ATGXG BAWUL BCRHZ BTFSW CITATION CS3 DU5 E3Z EBS EMOBN F9R GX1 H13 HZ~ INIJC KOP KQ8 L7B O9- OAUYM OBOKY OCZFY OJZSN OK1 OPAEJ OVD OWPYF P2P ROX SJN TBS TEORI TR2 W8F WOQ CGR CUY CVF DIK ECM EIF NPM RHF 7X8 NU- |
| ID | FETCH-LOGICAL-c295t-7befa536f93500a8683df92b5c67ff309c1eb2d492debac322c3fb8fda4f73e53 |
| ISSN | 0804-4643 1479-683X |
| IngestDate | Thu Jul 10 19:01:28 EDT 2025 Wed Feb 19 02:25:42 EST 2025 Tue Jul 01 04:13:37 EDT 2025 Thu Apr 24 22:57:27 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | acromegaly ectopic lipid deposition GH disorders growth hormone deficiency insulin resistance |
| Language | English |
| License | https://academic.oup.com/pages/standard-publication-reuse-rights The Author(s) 2023. Published by Oxford University Press on behalf of (ESE) European Society of Endocrinology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c295t-7befa536f93500a8683df92b5c67ff309c1eb2d492debac322c3fb8fda4f73e53 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-8424-558X 0000-0002-2442-6992 |
| PMID | 36651164 |
| PQID | 2766720804 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_2766720804 pubmed_primary_36651164 crossref_citationtrail_10_1093_ejendo_lvac014 crossref_primary_10_1093_ejendo_lvac014 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-01-10 |
| PublicationDateYYYYMMDD | 2023-01-10 |
| PublicationDate_xml | – month: 01 year: 2023 text: 2023-01-10 day: 10 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | European journal of endocrinology |
| PublicationTitleAlternate | Eur J Endocrinol |
| PublicationYear | 2023 |
| References | Schilbach (2023072118394301100_lvac014-B34) 2019; 181 Wiesli (2023072118394301100_lvac014-B58) 2005; 352 Arlien-Soborg (2023072118394301100_lvac014-B36) 2020; 105 Meienberg (2023072118394301100_lvac014-B29) 2016; 85 Arlien-Soborg (2023072118394301100_lvac014-B35) 2022; 75 Liu (2023072118394301100_lvac014-B54) 2016; 86 Moller (2023072118394301100_lvac014-B41) 1992; 74 Krssak (2023072118394301100_lvac014-B10) 2004; 53 Madsen (2023072118394301100_lvac014-B43) 2012; 97 Ichikawa (2023072118394301100_lvac014-B28) 2003; 52 Moller (2023072118394301100_lvac014-B44) 1995; 80 Vila (2023072118394301100_lvac014-B4) 2019; 10 Moller (2023072118394301100_lvac014-B38) 2008; 114 Fellinger (2023072118394301100_lvac014-B32) 2020; 5 Takahashi (2023072118394301100_lvac014-B51) 2007; 132 Corbit (2023072118394301100_lvac014-B15) 2018; 67 Chiang (2023072118394301100_lvac014-B62) 2016; 48 Moller (2023072118394301100_lvac014-B42) 2009; 30 Kantartzis (2023072118394301100_lvac014-B57) 2009; 17 Samuel (2023072118394301100_lvac014-B7) 2012; 148 Guo (2023072118394301100_lvac014-B2) 2018; 2018 Gardner (2023072118394301100_lvac014-B31) 2012; 166 Dal (2023072118394301100_lvac014-B45) 2016; 101 Bidlingmaier (2023072118394301100_lvac014-B33) 2014; 99 Sarmento-Cabral (2023072118394301100_lvac014-B27) 2021; 248 Xie (2023072118394301100_lvac014-B40) 2018; 62 Ryo (2023072118394301100_lvac014-B53) 2004; 68 Grat (2023072118394301100_lvac014-B63) 2020; 8 Yuen (2023072118394301100_lvac014-B50) 2014; 99 Kuker (2023072118394301100_lvac014-B46) 2021; 5 Barclay (2023072118394301100_lvac014-B47) 2011; 152 Osganian (2023072118394301100_lvac014-B49) 2022; 65 Dichtel (2023072118394301100_lvac014-B19) 2022; 107 Freda (2023072118394301100_lvac014-B30) 2008; 93 Rigamonti (2023072118394301100_lvac014-B60) 2012; 61 Yamauchi (2023072118394301100_lvac014-B55) 2001; 7 Bredella (2023072118394301100_lvac014-B1) 2017; 102 Lettner (2023072118394301100_lvac014-B5) 2008; 8 Hotta (2023072118394301100_lvac014-B52) 2000; 20 Roden (2023072118394301100_lvac014-B9) 2006; 2 Neggers (2023072118394301100_lvac014-B25) 2011; 164 Dichtel (2023072118394301100_lvac014-B20) 2022; 107 Olarescu (2023072118394301100_lvac014-B14) 2016; 27 Stefan (2023072118394301100_lvac014-B56) 2008; 29 Faraj (2023072118394301100_lvac014-B61) 2008; 34 Reyes-Vidal (2023072118394301100_lvac014-B21) 2015; 100 Dal (2023072118394301100_lvac014-B24) 2018; 178 Goodpaster (2023072118394301100_lvac014-B12) 2000; 71 Lam (2023072118394301100_lvac014-B59) 2004; 89 Goodpaster (2023072118394301100_lvac014-B11) 2001; 86 Kelley (2023072118394301100_lvac014-B8) 2003; 285 Wallace (2023072118394301100_lvac014-B37) 2004; 27 Liu (2023072118394301100_lvac014-B26) 2016; 65 Bredella (2023072118394301100_lvac014-B17) 2009; 94 Lewin (2023072118394301100_lvac014-B23) 1992; 54 Krssak (2023072118394301100_lvac014-B6) 2004; 5 Jorgensen (2023072118394301100_lvac014-B3) 1996; 45 Perseghin (2023072118394301100_lvac014-B13) 2003; 285 Caro (2023072118394301100_lvac014-B48) 1988; 81 Krag (2023072118394301100_lvac014-B18) 2007; 292 Fan (2023072118394301100_lvac014-B16) 2009; 284 Strowski (2023072118394301100_lvac014-B22) 2000; 141 Winhofer (2023072118394301100_lvac014-B39) 2014; 99 |
| References_xml | – volume: 71 start-page: 885 issue: 4 year: 2000 ident: 2023072118394301100_lvac014-B12 article-title: Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus publication-title: Am J Clin Nutr doi: 10.1093/ajcn/71.4.885 – volume: 80 start-page: 1789 year: 1995 ident: 2023072118394301100_lvac014-B44 article-title: Somatostatin enhances insulin-stimulated glucose uptake in the perfused human forearm publication-title: J Clin Endocrinol Metab – volume: 99 start-page: E1862 issue: 10 year: 2014 ident: 2023072118394301100_lvac014-B50 article-title: Short-term, low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2014-1532 – volume: 54 start-page: 455 issue: 1 year: 1992 ident: 2023072118394301100_lvac014-B23 article-title: The somatostatin receptor in the GI tract publication-title: Annu Rev Physiol doi: 10.1146/annurev.ph.54.030192.002323 – volume: 27 start-page: 1487 issue: 6 year: 2004 ident: 2023072118394301100_lvac014-B37 article-title: Use and abuse of HOMA modeling publication-title: Diabetes Care doi: 10.2337/diacare.27.6.1487 – volume: 164 start-page: 11 issue: 1 year: 2011 ident: 2023072118394301100_lvac014-B25 article-title: Hypothesis: extra-hepatic acromegaly: a new paradigm? publication-title: Eur J Endocrinol doi: 10.1530/EJE-10-0969 – volume: 67 start-page: 208 issue: 2 year: 2018 ident: 2023072118394301100_lvac014-B15 article-title: Adipocyte JAK2 regulates hepatic insulin sensitivity independently of body composition, liver lipid content, and hepatic insulin signaling publication-title: Diabetes doi: 10.2337/db17-0524 – volume: 29 start-page: 939 issue: 7 year: 2008 ident: 2023072118394301100_lvac014-B56 article-title: Causes and metabolic consequences of fatty liver publication-title: Endocr Rev doi: 10.1210/er.2008-0009 – volume: 107 start-page: e3624 issue: 9 year: 2022 ident: 2023072118394301100_lvac014-B20 article-title: The GH/IGF-1 axis is associated with intrahepatic lipid content and hepatocellular damage in overweight/obesity publication-title: J Clin Endocrinol Metab doi: 10.1210/clinem/dgac405 – volume: 152 start-page: 181 issue: 1 year: 2011 ident: 2023072118394301100_lvac014-B47 article-title: GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism publication-title: Endocrinology doi: 10.1210/en.2010-0537 – volume: 62 start-page: 552 issue: 3 year: 2018 ident: 2023072118394301100_lvac014-B40 article-title: Dynamic changes in the distribution of facial and abdominal adipose tissue correlated with surgical treatment in acromegaly publication-title: Endocrine doi: 10.1007/s12020-018-1742-x – volume: 94 start-page: 3995 issue: 10 year: 2009 ident: 2023072118394301100_lvac014-B17 article-title: Peak growth hormone-releasing hormone-arginine-stimulated growth hormone is inversely associated with intramyocellular and intrahepatic lipid content in premenopausal women with obesity publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2009-0438 – volume: 284 start-page: 19937 issue: 30 year: 2009 ident: 2023072118394301100_lvac014-B16 article-title: Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism publication-title: J Biol Chem doi: 10.1074/jbc.M109.014308 – volume: 68 start-page: 975 issue: 11 year: 2004 ident: 2023072118394301100_lvac014-B53 article-title: Adiponectin as a biomarker of the metabolic syndrome publication-title: Circ J doi: 10.1253/circj.68.975 – volume: 52 start-page: 914 issue: 6 year: 2003 ident: 2023072118394301100_lvac014-B28 article-title: Non-alcoholic steatohepatitis and hepatic steatosis in patients with adult onset growth hormone deficiency publication-title: Gut doi: 10.1136/gut.52.6.914 – volume: 8 start-page: 298 issue: 9 year: 2020 ident: 2023072118394301100_lvac014-B63 article-title: Usefulness of different imaging modalities in evaluation of patients with non-alcoholic fatty liver disease publication-title: Biomedicines doi: 10.3390/biomedicines8090298 – volume: 85 start-page: 76 issue: 1 year: 2016 ident: 2023072118394301100_lvac014-B29 article-title: Liver fat in adults with GH deficiency: comparison to matched controls and the effect of GH replacement publication-title: Clin Endocrinol (Oxf) doi: 10.1111/cen.13042 – volume: 107 start-page: 1812 issue: 7 year: 2022 ident: 2023072118394301100_lvac014-B19 article-title: Growth hormone and insulin-like growth factor 1 regulation of nonalcoholic fatty liver disease publication-title: J Clin Endocrinol Metab doi: 10.1210/clinem/dgac088 – volume: 74 start-page: 1012 year: 1992 ident: 2023072118394301100_lvac014-B41 article-title: Basal- and insulin-stimulated substrate metabolism in patients with active acromegaly before and after adenomectomy publication-title: J Clin Endocrinol Metab – volume: 352 start-page: 175 issue: 1-2 year: 2005 ident: 2023072118394301100_lvac014-B58 article-title: Effect of pituitary surgery in patients with acromegaly on adiponectin serum concentrations and alanine aminotransferase activity publication-title: Clin Chim Acta doi: 10.1016/j.cccn.2004.09.022 – volume: 2 start-page: 335 issue: 6 year: 2006 ident: 2023072118394301100_lvac014-B9 article-title: Mechanisms of disease: hepatic steatosis in type 2 diabetes–pathogenesis and clinical relevance publication-title: Nat Clin Pract Endocrinol Metab doi: 10.1038/ncpendmet0190 – volume: 285 start-page: E906 issue: 4 year: 2003 ident: 2023072118394301100_lvac014-B8 article-title: Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00117.2003 – volume: 181 start-page: 55 issue: 1 year: 2019 ident: 2023072118394301100_lvac014-B34 article-title: Determinants of the growth hormone nadir during oral glucose tolerance test in adults publication-title: Eur J Endocrinol doi: 10.1530/EJE-19-0139 – volume: 86 start-page: 100 year: 2016 ident: 2023072118394301100_lvac014-B54 article-title: Adiponectin, TNF-alpha and inflammatory cytokines and risk of type 2 diabetes: a systematic review and meta-analysis publication-title: Cytokine doi: 10.1016/j.cyto.2016.06.028 – volume: 5 start-page: bvab004 issue: 3 year: 2021 ident: 2023072118394301100_lvac014-B46 article-title: Body composition changes with long-term pegvisomant therapy of acromegaly publication-title: J Endocr Soc doi: 10.1210/jendso/bvab004 – volume: 100 start-page: 2946 issue: 8 year: 2015 ident: 2023072118394301100_lvac014-B21 article-title: Adipose tissue redistribution and ectopic lipid deposition in active acromegaly and effects of surgical treatment publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2015-1917 – volume: 75 start-page: 103763 year: 2022 ident: 2023072118394301100_lvac014-B35 article-title: Reversible insulin resistance in muscle and fat unrelated to the metabolic syndrome in patients with acromegaly publication-title: EBioMedicine doi: 10.1016/j.ebiom.2021.103763 – volume: 17 start-page: 390 issue: 2 year: 2009 ident: 2023072118394301100_lvac014-B57 article-title: Adiponectin oligomers and ectopic fat in liver and skeletal muscle in humans publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2008.487 – volume: 30 start-page: 152 issue: 2 year: 2009 ident: 2023072118394301100_lvac014-B42 article-title: Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects publication-title: Endocr Rev doi: 10.1210/er.2008-0027 – volume: 45 start-page: 681 issue: 6 year: 1996 ident: 2023072118394301100_lvac014-B3 article-title: Growth hormone versus placebo treatment for one year in growth hormone deficient adults: increase in exercise capacity and normalization of body composition publication-title: Clin Endocrinol (Oxf) doi: 10.1046/j.1365-2265.1996.8720883.x – volume: 166 start-page: 993 issue: 6 year: 2012 ident: 2023072118394301100_lvac014-B31 article-title: Hepatic steatosis, GH deficiency and the effects of GH replacement: a liverpool magnetic resonance spectroscopy study publication-title: Eur J Endocrinol doi: 10.1530/EJE-12-0002 – volume: 148 start-page: 852 issue: 5 year: 2012 ident: 2023072118394301100_lvac014-B7 article-title: Mechanisms for insulin resistance: common threads and missing links publication-title: Cell doi: 10.1016/j.cell.2012.02.017 – volume: 7 start-page: 941 issue: 8 year: 2001 ident: 2023072118394301100_lvac014-B55 article-title: The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity publication-title: Nat Med doi: 10.1038/90984 – volume: 65 start-page: 3598 issue: 12 year: 2016 ident: 2023072118394301100_lvac014-B26 article-title: Growth hormone control of hepatic lipid metabolism publication-title: Diabetes doi: 10.2337/db16-0649 – volume: 20 start-page: 1595 issue: 6 year: 2000 ident: 2023072118394301100_lvac014-B52 article-title: Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.20.6.1595 – volume: 86 start-page: 5755 issue: 12 year: 2001 ident: 2023072118394301100_lvac014-B11 article-title: Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.86.12.8075 – volume: 61 start-page: 1797 issue: 12 year: 2012 ident: 2023072118394301100_lvac014-B60 article-title: Effect of a somatostatin infusion on circulating levels of adipokines in obese women publication-title: Metab Clin Exp. doi: 10.1016/j.metabol.2012.05.019 – volume: 48 start-page: 1003 issue: 4 year: 2016 ident: 2023072118394301100_lvac014-B62 article-title: Magnetic resonance spectroscopy in living-donor liver transplantation publication-title: Transplant Proc doi: 10.1016/j.transproceed.2015.10.068 – volume: 81 start-page: 976 issue: 4 year: 1988 ident: 2023072118394301100_lvac014-B48 article-title: Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver publication-title: J Clin Invest doi: 10.1172/JCI113451 – volume: 27 start-page: 226 issue: 4 year: 2016 ident: 2023072118394301100_lvac014-B14 article-title: The impact of adipose tissue on insulin resistance in acromegaly publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2016.02.005 – volume: 292 start-page: E920 issue: 3 year: 2007 ident: 2023072118394301100_lvac014-B18 article-title: Growth hormone-induced insulin resistance is associated with increased intramyocellular triglyceride content but unaltered VLDL-triglyceride kinetics publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00374.2006 – volume: 5 start-page: 127 issue: 2 year: 2004 ident: 2023072118394301100_lvac014-B6 article-title: The role of lipid accumulation in liver and muscle for insulin resistance and type 2 diabetes mellitus in humans publication-title: Rev Endocr Metab Disord doi: 10.1023/B:REMD.0000021434.98627.dc – volume: 65 start-page: 101482 year: 2022 ident: 2023072118394301100_lvac014-B49 article-title: Expression of IGF-1 receptor and GH receptor in hepatic tissue of patients with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis publication-title: Growth Horm IGF Res doi: 10.1016/j.ghir.2022.101482 – volume: 114 start-page: 547 issue: 8 year: 2008 ident: 2023072118394301100_lvac014-B38 article-title: Fasting in healthy subjects is associated with intrahepatic accumulation of lipids as assessed by 1H-magnetic resonance spectroscopy publication-title: Clin Sci (Lond) doi: 10.1042/CS20070217 – volume: 132 start-page: 938 issue: 3 year: 2007 ident: 2023072118394301100_lvac014-B51 article-title: Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency publication-title: Gastroenterology doi: 10.1053/j.gastro.2006.12.024 – volume: 2018 start-page: 4125013 year: 2018 ident: 2023072118394301100_lvac014-B2 article-title: Pre- and postoperative body composition and metabolic characteristics in patients with acromegaly: a prospective study publication-title: Int J Endocrinol doi: 10.1155/2018/4125013 – volume: 8 start-page: 185 issue: 3 year: 2008 ident: 2023072118394301100_lvac014-B5 article-title: Ectopic fat and insulin resistance publication-title: Curr Diab Rep doi: 10.1007/s11892-008-0032-z – volume: 89 start-page: 5448 issue: 11 year: 2004 ident: 2023072118394301100_lvac014-B59 article-title: Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-032023 – volume: 10 start-page: 509 year: 2019 ident: 2023072118394301100_lvac014-B4 article-title: Insulin resistance in patients with acromegaly publication-title: Front Endocrinol (Lausanne) doi: 10.3389/fendo.2019.00509 – volume: 34 start-page: 334 issue: 4 year: 2008 ident: 2023072118394301100_lvac014-B61 article-title: Regulation of leptin, adiponectin and acylation-stimulating protein by hyperinsulinaemia and hyperglycaemia in vivo in healthy lean young men publication-title: Diabetes Metab doi: 10.1016/j.diabet.2008.01.014 – volume: 99 start-page: 1712 issue: 5 year: 2014 ident: 2023072118394301100_lvac014-B33 article-title: Reference intervals for insulin-like growth factor-1 (IGF-I) from birth to senescence: results from a multicenter study using a new automated chemiluminescence IGF-I immunoassay conforming to recent international recommendations publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2013-3059 – volume: 102 start-page: 4218 issue: 11 year: 2017 ident: 2023072118394301100_lvac014-B1 article-title: Body composition and ectopic lipid changes with biochemical control of acromegaly publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2017-01210 – volume: 53 start-page: 3048 issue: 12 year: 2004 ident: 2023072118394301100_lvac014-B10 article-title: Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes publication-title: Diabetes doi: 10.2337/diabetes.53.12.3048 – volume: 285 start-page: E1174 issue: 6 year: 2003 ident: 2023072118394301100_lvac014-B13 article-title: Insulin resistance, intramyocellular lipid content, and plasma adiponectin in patients with type 1 diabetes publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00279.2003 – volume: 97 start-page: 1227 issue: 4 year: 2012 ident: 2023072118394301100_lvac014-B43 article-title: Fat content in liver and skeletal muscle changes in a reciprocal manner in patients with acromegaly during combination therapy with a somatostatin analog and a GH receptor antagonist: a randomized clinical trial publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2011-2681 – volume: 248 start-page: 31 issue: 1 year: 2021 ident: 2023072118394301100_lvac014-B27 article-title: GH directly inhibits steatosis and liver injury in a sex-dependent and IGF1-independent manner publication-title: J Endocrinol doi: 10.1530/JOE-20-0326 – volume: 141 start-page: 111 issue: 1 year: 2000 ident: 2023072118394301100_lvac014-B22 article-title: Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice publication-title: Endocrinology doi: 10.1210/endo.141.1.7263 – volume: 178 start-page: 65 issue: 1 year: 2018 ident: 2023072118394301100_lvac014-B24 article-title: Targeting either GH or IGF-I during somatostatin analogue treatment in patients with acromegaly: a randomized multicentre study publication-title: Eur J Endocrinol doi: 10.1530/EJE-17-0546 – volume: 105 start-page: dgz033 issue: 1 year: 2020 ident: 2023072118394301100_lvac014-B36 article-title: Fibroblast activation protein is a GH target: a prospective study of patients with acromegaly before and after treatment publication-title: J Clin Endocrinol Metab doi: 10.1210/clinem/dgz033 – volume: 93 start-page: 2334 issue: 6 year: 2008 ident: 2023072118394301100_lvac014-B30 article-title: Lower visceral and subcutaneous but higher intermuscular adipose tissue depots in patients with growth hormone and insulin-like growth factor I excess due to acromegaly publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2007-2780 – volume: 101 start-page: 3716 issue: 10 year: 2016 ident: 2023072118394301100_lvac014-B45 article-title: Growth hormone and insulin signaling in acromegaly: impact of surgery versus somatostatin analog treatment publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2016-1806 – volume: 99 start-page: 4299 issue: 11 year: 2014 ident: 2023072118394301100_lvac014-B39 article-title: No evidence of ectopic lipid accumulation in the pathophysiology of the acromegalic cardiomyopathy publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2014-2242 – volume: 5 start-page: e134638 issue: 5 year: 2020 ident: 2023072118394301100_lvac014-B32 article-title: Increased ATP synthesis might counteract hepatic lipid accumulation in acromegaly publication-title: JCI Insight doi: 10.1172/jci.insight.134638 |
| SSID | ssj0016430 |
| Score | 2.4262254 |
| Snippet | Insulin resistance is associated with ectopic lipid deposition. Growth hormone (GH) status also modulates ectopic lipid accumulation, but how this associates... |
| SourceID | proquest pubmed crossref |
| SourceType | Aggregation Database Index Database Enrichment Source |
| StartPage | 78 |
| SubjectTerms | Acromegaly - complications Acromegaly - drug therapy Adult Body Composition Growth Hormone - deficiency Human Growth Hormone - therapeutic use Humans Insulin Resistance Insulin-Like Growth Factor I - metabolism Lipids |
| Title | Ectopic lipid deposition and insulin resistance in patients with GH disorders before and after treatment |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/36651164 https://www.proquest.com/docview/2766720804 |
| Volume | 188 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKkKa9INi4jJuMhOChMkvjxIkfC4xVSOOFTepb5FtGR5tUbYoE_4H_zPElaVeoBLxEkS-xku-LfXz8-RihlywHK38gUjJINSeJMYZwGPcJZ5nMcp5kiXBqi09sdJl8HKfjXu_nhmpp1cg36scf95X8D6qQBrjaXbL_gGz3UEiAe8AXroAwXP8K41PV1POJ6k8n84m2otagwAohlbzKHObT1ka0P_A6jmrY1HY2sis0Lvzmsi8NGLB-NcGfHN6J0He674MpaypdQ-9z00U_XIB5W5HPdin-bQ5Uu_J7gyZrx-y50MEBFNT7_eF02jHtvfDuafG1lt24sLAuo2Vzbd2YZCTKZbPwDcy25E7BkxFbHRcJmlbje98k44Tl7oDgje453-bhb92-D4llru3rws30m1CR35u6wYL5zNGAMgZGpg-dvhVqu826hW7HMOtwJ4GMO8UQZNCoi_tJT3xzJ6GxA7TfVr9p4uyYtzj75eIuuhMmHnjoWXQP9Ux1iI6GlWjq2Xf8CjspsAPwEO2fB8XFEfoSOIYdx_CaYxh4ggPH8JpjkIRbjmHLMXw2wh3HsOeYq-s4hjuO3UeXH04v3o1IOJ2DqJinDcmghkgpKzlNo0jkgJsueSxTxbKypBFXAyNjnfBYGykUDByKljIvtUjKjJqUPkB7VV2ZRwgnsuQm0cpGX0tKa5WySOnUpDk1sc7kMSLtBy1UCF1vT1CZFl5CQQuPRRGwOEavu_JzH7RlZ8kXLT4F9Kt2sUxUpl4tizhjDCiQR1DmoQeue1YL9OOdOU_QwZrhT9Fes1iZZ2C9NvK549QvBFOh4g |
| linkProvider | Geneva Foundation for Medical Education and Research |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Ectopic+lipid+deposition+and+insulin+resistance+in+patients+with+GH+disorders+before+and+after+treatment&rft.jtitle=European+journal+of+endocrinology&rft.au=Arlien-S%C3%B8borg%2C+Mai+C&rft.au=Madsen%2C+Michael+Alle&rft.au=Dal%2C+Jakob&rft.au=Krusenstjerna-Hafstr%C3%B8m%2C+Thomas&rft.date=2023-01-10&rft.eissn=1479-683X&rft.volume=188&rft.issue=1&rft_id=info:doi/10.1093%2Fejendo%2Flvac014&rft_id=info%3Apmid%2F36651164&rft.externalDocID=36651164 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0804-4643&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0804-4643&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0804-4643&client=summon |