Inhibition of GPR4 attenuates SH-SY5Y cell injury in cerebral ischemia/reperfusion via anti-apoptotic pathways

• Published in: Acta biochimica Polonica
• Main Authors: Xing, Chunli, Yan, Guizhen, Liu, Qishuai
• Format: Journal Article
• Language: English
• Published: Poland 07.04.2021

Cerebral ischemia/reperfusion injury (CIRI) can lead to increased vascular endothelial permeability and blood-brain barrier damage in patients with stroke. G protein-coupled receptor 4 (GPR4) is a functional pH sensor that plays a key role in renal ischemia-reperfusion-induced apoptosis. However, wh...