Assessment of the recovery of dynamic balance after intravenous sedation with midazolam

• Published in: Journal of anesthesia Vol. 19; no. 1; pp. 26 - 30
• Main Authors: Fujisawa, Toshiaki, Takuma, Shigeru, Koseki, Hiroyo, Kimura, Kunie, Fukushima, Kazuaki
• Format: Journal Article
• Language: English
• Published: Japan Springer 01.02.2005
• Subjects: Adult; Conscious Sedation; Diagnosis; Diagnostic imaging; Dosage and administration; Dynamic balance; Equilibrium (Physiology); Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - pharmacology; Injections, Intravenous; Male; Midazolam; Midazolam - administration & dosage; Midazolam - pharmacology; Postural Balance - drug effects; Recovery of function; Walking; Japan
• ISSN: 0913-8668; 1438-8359
• DOI: 10.1007/s00540-004-0286-9

To assess street fitness after sedation, computerized dynamic posturography (CDP) involving movement of the center of gravity may be more accurate than the conventional computerized static posturography (CSP). The purpose of this study was to evaluate the recovery of dynamic balance function after intravenous sedation by CDP in comparison with CSP, and to find a simple dynamic balance test that is well correlated with CDP. The subjects were 20 male volunteers aged 20-27 years. After intravenous injection of midazolam (0.07 mg . kg(-1)), four balance tests were performed. The recovery time and the percentage of subjects showing recovery (difference from the baseline value < or =10%) were compared. As CDP, a test in which unexpected perturbation stimuli are given using an unstable platform was performed. As CSP, standing sway tests were performed. Maximum speed walking (MSW) and usual speed walking (USW) tests were performed as simple balance tests. The recovery time in CDP (80 min) was longer than that in CSP (40-60 min). The percentage of subjects showing recovery in CDP (20%) was significantly lower than that in CSP (55%-70%) 60 min after the administration of midazolam. There was a significant positive correlation between the CDP test and the MSW test (r = 0.67). CDP with perturbation stimuli detects the balance inhibitory effects of midazolam with greater sensitivity than CSP. The MSW test is well correlated with CDP with perturbation stimuli.