Design and synthesis of novel type VI-like β-turn mimetics. Diversity at the i+1 and the i+2 position

In this paper, a synthetic approach for functionalised 5-aminopiperidinone-2-carboxylate (APC) systems as non-pro cis-peptide bond containing external β-turn mimics is presented. The scope and limitations of the synthetic method are discussed and the potential turn inducing properties of a model com...

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Published inTetrahedron Vol. 60; no. 50; pp. 11597 - 11612
Main Authors De Borggraeve, Wim M., Verbist, Bie M.P., Rombouts, Frederik J.R., Pawar, Vijaykumar G., Smets, Wim J., Kamoune, Laila, Alen, Jo, Van der Eycken, Erik V., Compernolle, Frans, Hoornaert, Georges J.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 06.12.2004
Elsevier
Subjects
Chemistry
Chemistry, Organic
Diels–Alder reaction
Physical Sciences
Pyrazinone
Science & Technology
Turn mimics
Diels–Alder reaction
Turn mimics
Pyrazinone
PEPTIDE-BONDS
DIELS-ALDER REACTIONS
turn mimics
POLYPEPTIDES
STABILIZE SECONDARY STRUCTURES
GLY-PRO
AMINO-ACIDS
pyrazinone
2(1H)-PYRAZINONES
GENERATION
Diels-Alder reaction
CONFORMATIONAL-ANALYSIS
DERIVATIVES
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Abstract In this paper, a synthetic approach for functionalised 5-aminopiperidinone-2-carboxylate (APC) systems as non-pro cis-peptide bond containing external β-turn mimics is presented. The scope and limitations of the synthetic method are discussed and the potential turn inducing properties of a model compound are evaluated by means of molecular modelling and NMR analysis. Graphical Abstract
AbstractList In this paper, a synthetic approach for functionalised 5-aminopiperidinone-2-carboxylate (APC) systems as non-pro cis-peptide bond containing external β-turn mimics is presented. The scope and limitations of the synthetic method are discussed and the potential turn inducing properties of a model compound are evaluated by means of molecular modelling and NMR analysis. Graphical Abstract
In this paper, a synthetic approach for functionalised 5-aminopiperidinone-2-carboxylate (APC) systems as non-pro cis-peptide bond containing external beta-turn mimics is presented. The scope and limitations of the synthetic method are discussed and the potential turn inducing properties of a model compound are evaluated by means of molecular modelling and NMR analysis. (C) 2004 Elsevier Ltd. All rights reserved.
Author Rombouts, Frederik J.R.
Pawar, Vijaykumar G.
De Borggraeve, Wim M.
Kamoune, Laila
Alen, Jo
Hoornaert, Georges J.
Compernolle, Frans
Verbist, Bie M.P.
Smets, Wim J.
Van der Eycken, Erik V.
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Cites_doi 10.1021/jo0263216
10.1021/cc0300098
10.1006/abio.2000.4757
10.1016/S0040-4020(03)00826-3
10.1016/j.tetlet.2004.03.186
10.1016/j.tetlet.2004.01.017
10.1002/ejoc.200200652
10.1016/S0040-4020(03)00741-5
10.1016/S0040-4020(03)00732-4
10.1016/S0040-4039(00)87700-X
10.1006/jmbi.1998.2459
10.1021/jo00186a042
10.1002/recl.19941130102
10.1016/S0040-4039(01)01080-2
10.2174/0929867003374499
10.1038/1368
10.1016/S0040-4039(01)02188-8
10.1023/B:MODI.0000006807.43408.d5
10.1016/S0040-4020(98)00802-3
10.1021/ol049979+
10.1016/S0040-4039(00)76740-2
10.1002/jcc.540110405
10.1016/S0040-4039(00)87699-6
10.1021/jo960012w
10.1002/jhet.5570200414
10.1016/0040-4020(95)00802-F
10.1016/S0040-4020(97)00298-6
10.1016/S0040-4020(01)90216-9
10.1016/S0040-4039(00)75983-1
10.1021/ja970855k
10.1016/S0040-4020(01)90207-8
10.1016/S0040-4039(01)01545-3
10.1002/jmr.300030202
10.1039/p19960000231
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Issue 50
Keywords Diels–Alder reaction
Turn mimics
Pyrazinone
PEPTIDE-BONDS
DIELS-ALDER REACTIONS
turn mimics
POLYPEPTIDES
STABILIZE SECONDARY STRUCTURES
GLY-PRO
AMINO-ACIDS
pyrazinone
2(1H)-PYRAZINONES
GENERATION
Diels-Alder reaction
CONFORMATIONAL-ANALYSIS
DERIVATIVES
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References Gramberg, Robinson (bib8) 1994; 35
Ball, Alewood (bib4) 1990; 3
Kemp, McNamara, Kemp, McNamara, Kemp, Sun (bib6) 1982; 23
Nagai, Sato, Nakamura, Kato (bib5) 1993; 49
Rombouts, De Borggraeve, Delaere, Froeyen, Toppet, Compernolle, Hoornaert, Takeuchi, Marshall (bib9) 2003; 120
Hruby, Balse, Hanessian, McNaughtonSmith, Lombart, Lubell, Liskamp (bib3) 2000; 7
Hoye, Eklov, Ryba, Voloshin, Yao (bib23) 2004; 6
Mohamadi, Richards, Guida, Liskamp, Lipton, Caufield, Chang, Hendrickson, Still (bib10) 1990; 11
Weiss, Jabs, Hilgenfeld, Jabs, Weiss, Hilgenfeld (bib1) 1998; 5
In the publication by Marshall, another definition of the angle β is used. We took the original definition as given by Ball.
bib25
Ball, Hughes, Alewood, Andrews (bib11) 1993; 49
bib24
Verbist, Smets, De Borggraeve, Compernolle, Hoornaert (bib20) 2004; 45
De Borggraeve, Rombouts, Van der Eycken, Toppet, Hoornaert (bib14) 2001; 42
Rogiers, De Borggraeve, Toppet, Compernolle, Hoornaert (bib21) 2003; 59
Van der Eycken, Appukkuttan, De Borggraeve, Dehaen, Dallinger, Kappe (bib19) 2002; 67
Azzam, De Borggraeve, Compernolle, Hoornaert, De Borggraeve, Rombouts, Verbist, Van der Eycken, Hoornaert, Rombouts, De Borggraeve, Toppet, Compernolle, Hoornaert, Rombouts, Van den Bossche, Toppet, Compernolle, Hoornaert, Govaerts, Vogels, Compernolle, Hoornaert, Tahri, Buysens, Van der Eycken, Vandenberghe, Hoornaert, Buysens, Vandenberghe, Toppet, Hoornaert, Buysens, Vandenberghe, Toppet, Hoornaert, Kaval, Van Der Eycken, Caroen, Dehaen, Strohmeier, Kappe, Van Der Eycken, Kaval, Bisztray, Dehaen, Kappe, Van der Eycken (bib15) 2004; 45
bib18
Vekemans, Pollers-Wieërs, Hoornaert (bib13) 1983; 20
bib16
bib17
Pataï (bib22) 1970
Dumas, Germanas, Kim, Dumas, Germanas (bib7) 1994; 35
Chou (bib2) 2000; 286
HOYE TR (WOS:000225148000031.13) 2004; 6
Rogiers, J (WOS:000183860800016) 2003; 59
BALL, JB (WOS:A1993LA10200004) 1993; 49
Takeuchi, Y (WOS:000074213800002) 1998; 120
VEKEMANS, J (WOS:A1983RE04100014) 1983; 20
KEMP, DS (WOS:A1982PE98500007) 1982; 23
Govaerts, TC (WOS:000184164900013) 2003; 59
Jabs, A (WOS:000078702000023) 1999; 286
MOHAMADI, F (WOS:A1990CZ22100004) 1990; 11
Tahri, A (WOS:000076290600019) 1998; 54
LISKAMP, RMJ (WOS:A1994NC25600001) 1994; 113
Verbist, BMP (WOS:000221564200039) 2004; 45
Rombouts, FJR (WOS:000183780900002) 2003; 59
PATAI S (WOS:000225148000031.25) 1970
De Borggraeve, WM (WOS:000173262000026) 2002; 43
Chou, KC (WOS:000165201200001) 2000; 286
Kim, KH (WOS:A1996UJ09400037) 1996; 61
BUYSENS, KJ (WOS:A1995TD21800027) 1995; 51
Rombouts, FJR (WOS:000171456400017) 2001; 42
Weiss, MS (WOS:000075044600009) 1998; 5
Rombouts, FJR (WOS:000183105000007) 2003; 2003
KEMP, DS (WOS:A1982PE98500006) 1982; 23
Kaval, N (WOS:000207200600005) 2003; 7
GRAMBERG, D (WOS:A1994MV16900014) 1994; 35
Azzam, R (WOS:000189116200016) 2004; 45
NAGAI, U (WOS:A1993LA10200013) 1993; 49
Van der Eycken, E (WOS:000178820200052) 2002; 67
De Borggraeve, WM (WOS:000170309700025) 2001; 42
Kaval, N (WOS:000185247200003) 2003; 5
KEMP, DS (WOS:A1984SW65900042) 1984; 49
Hanessian, S (WOS:A1997XW84000002) 1997; 53
Hruby, VJ (WOS:000088981000006) 2000; 7
DUMAS, JP (WOS:A1994MZ86100007) 1994; 35
Buysens, KJ (WOS:A1996TU46300004) 1996
Ball, J B (MEDLINE:2163268) 1990; 3
Chou (10.1016/j.tet.2004.09.054_bib2) 2000; 286
Hoye (10.1016/j.tet.2004.09.054_bib23) 2004; 6
Ball (10.1016/j.tet.2004.09.054_bib4) 1990; 3
Weiss (10.1016/j.tet.2004.09.054_bib1_1) 1998; 5
Kim (10.1016/j.tet.2004.09.054_bib7_2) 1996; 61
Kaval (10.1016/j.tet.2004.09.054_bib15_10) 2003; 7
Hanessian (10.1016/j.tet.2004.09.054_bib3_2) 1997; 53
Van der Eycken (10.1016/j.tet.2004.09.054_bib19) 2002; 67
Azzam (10.1016/j.tet.2004.09.054_bib15_1) 2004; 45
Ball (10.1016/j.tet.2004.09.054_bib11) 1993; 49
Mohamadi (10.1016/j.tet.2004.09.054_bib10) 1990; 11
De Borggraeve (10.1016/j.tet.2004.09.054_bib14) 2001; 42
Hruby (10.1016/j.tet.2004.09.054_bib3_1) 2000; 7
10.1016/j.tet.2004.09.054_bib12
Rombouts (10.1016/j.tet.2004.09.054_bib9_1) 2003
Takeuchi (10.1016/j.tet.2004.09.054_bib9_2) 1998; 120
Vekemans (10.1016/j.tet.2004.09.054_bib13) 1983; 20
Dumas (10.1016/j.tet.2004.09.054_bib7_1) 1994; 35
Rombouts (10.1016/j.tet.2004.09.054_bib15_3) 2001; 42
Liskamp (10.1016/j.tet.2004.09.054_bib3_3) 1994; 113
Buysens (10.1016/j.tet.2004.09.054_bib15_8) 1996
Pataï (10.1016/j.tet.2004.09.054_bib22) 1970
Kemp (10.1016/j.tet.2004.09.054_bib6_1) 1982; 23
Nagai (10.1016/j.tet.2004.09.054_bib5) 1993; 49
Kemp (10.1016/j.tet.2004.09.054_bib6_3) 1982; 23
Kemp (10.1016/j.tet.2004.09.054_bib6_2) 1984; 49
De Borggraeve (10.1016/j.tet.2004.09.054_bib15_2) 2002; 43
Govaerts (10.1016/j.tet.2004.09.054_bib15_5) 2003; 59
Jabs (10.1016/j.tet.2004.09.054_bib1_2) 1999; 286
Kaval (10.1016/j.tet.2004.09.054_bib15_9) 2003; 5
Gramberg (10.1016/j.tet.2004.09.054_bib8) 1994; 35
Buysens (10.1016/j.tet.2004.09.054_bib15_7) 1995; 51
Rogiers (10.1016/j.tet.2004.09.054_bib21) 2003; 59
Rombouts (10.1016/j.tet.2004.09.054_bib15_4) 2003; 59
Tahri (10.1016/j.tet.2004.09.054_bib15_6) 1998; 54
Verbist (10.1016/j.tet.2004.09.054_bib20) 2004; 45
References_xml – ident: bib17
– volume: 5
  start-page: 676
  year: 1998
  end-page: 304
  ident: bib1
  publication-title: Nat. Struct. Biol.
  contributor:
    fullname: Hilgenfeld
– volume: 20
  start-page: 919
  year: 1983
  end-page: 923
  ident: bib13
  publication-title: J. Heterocycl. Chem.
  contributor:
    fullname: Hoornaert
– volume: 35
  start-page: 1493
  year: 1994
  end-page: 1496
  ident: bib7
  publication-title: Tetrahedron Lett.
  contributor:
    fullname: Germanas
– volume: 35
  start-page: 861
  year: 1994
  end-page: 864
  ident: bib8
  publication-title: Tetrahedron Lett.
  contributor:
    fullname: Robinson
– volume: 49
  start-page: 3577
  year: 1993
  end-page: 3592
  ident: bib5
  publication-title: Tetrahedron
  contributor:
    fullname: Kato
– ident: bib24
– volume: 120
  start-page: 1868
  year: 2003
  end-page: 1878
  ident: bib9
  publication-title: Eur. J. Org. Chem.
  contributor:
    fullname: Marshall
– volume: 11
  start-page: 440
  year: 1990
  end-page: 467
  ident: bib10
  publication-title: J. Comput. Chem.
  contributor:
    fullname: Still
– volume: 59
  start-page: 5047
  year: 2003
  end-page: 5054
  ident: bib21
  publication-title: Tetrahedron
  contributor:
    fullname: Hoornaert
– volume: 45
  start-page: 4371
  year: 2004
  end-page: 4374
  ident: bib20
  publication-title: Tetrahedron Lett.
  contributor:
    fullname: Hoornaert
– volume: 7
  start-page: 945
  year: 2000
  end-page: 970
  ident: bib3
  publication-title: Curr. Med. Chem.
  contributor:
    fullname: Liskamp
– volume: 45
  start-page: 1885
  year: 2004
  end-page: 1888
  ident: bib15
  publication-title: Tetrahedron Lett.
  contributor:
    fullname: Van der Eycken
– ident: bib16
– ident: bib18
– volume: 49
  start-page: 3467
  year: 1993
  end-page: 3478
  ident: bib11
  publication-title: Tetrahedron
  contributor:
    fullname: Andrews
– volume: 67
  start-page: 7904
  year: 2002
  end-page: 7907
  ident: bib19
  publication-title: J. Org. Chem.
  contributor:
    fullname: Kappe
– volume: 6
  start-page: 953
  year: 2004
  end-page: 956
  ident: bib23
  publication-title: J. Org. Lett.
  contributor:
    fullname: Yao
– year: 1970
  ident: bib22
  article-title: The Chemistry of Amides
  contributor:
    fullname: Pataï
– volume: 3
  start-page: 55
  year: 1990
  end-page: 64
  ident: bib4
  publication-title: J. Mol. Recognit.
  contributor:
    fullname: Alewood
– ident: bib25
– volume: 42
  start-page: 5693
  year: 2001
  end-page: 5695
  ident: bib14
  publication-title: Tetrahedron Lett.
  contributor:
    fullname: Hoornaert
– volume: 286
  start-page: 1
  year: 2000
  end-page: 16
  ident: bib2
  publication-title: Anal. Biochem.
  contributor:
    fullname: Chou
– volume: 23
  start-page: 3761
  year: 1982
  end-page: 3764
  ident: bib6
  publication-title: Tetrahedron Lett.
  contributor:
    fullname: Sun
– volume: 5
  start-page: 676
  year: 1998
  ident: WOS:000075044600009
  article-title: Peptide bonds revisited
  publication-title: NATURE STRUCTURAL BIOLOGY
  contributor:
    fullname: Weiss, MS
– volume: 67
  start-page: 7904
  year: 2002
  ident: WOS:000178820200052
  article-title: High-speed microwave-promoted hetero-Diels-Alder reactions of 2(1H)-pyrazinones in ionic liquid doped solvents
  publication-title: JOURNAL OF ORGANIC CHEMISTRY
  doi: 10.1021/jo0263216
  contributor:
    fullname: Van der Eycken, E
– volume: 49
  start-page: 3577
  year: 1993
  ident: WOS:A1993LA10200013
  article-title: BICYCLIC TURNED DIPEPTIDE (BTD) AS A BETA-TURN MIMETIC - ITS DESIGN, SYNTHESIS AND INCORPORATION INTO BIOACTIVE PEPTIDES
  publication-title: TETRAHEDRON
  contributor:
    fullname: NAGAI, U
– volume: 11
  start-page: 440
  year: 1990
  ident: WOS:A1990CZ22100004
  article-title: MACROMODEL - AN INTEGRATED SOFTWARE SYSTEM FOR MODELING ORGANIC AND BIOORGANIC MOLECULES USING MOLECULAR MECHANICS
  publication-title: JOURNAL OF COMPUTATIONAL CHEMISTRY
  contributor:
    fullname: MOHAMADI, F
– volume: 61
  start-page: 3138
  year: 1996
  ident: WOS:A1996UJ09400037
  article-title: Novel bicyclic lactams as XaaPro type VI beta turn mimics: Design, synthesis, and evaluation
  publication-title: JOURNAL OF ORGANIC CHEMISTRY
  contributor:
    fullname: Kim, KH
– volume: 35
  start-page: 861
  year: 1994
  ident: WOS:A1994MV16900014
  article-title: DESIGN AND SYNTHESIS OF A CIS-GLY-PRO, TYPE-VI TURN, DIPEPTIDE MIMETIC AND ITS USE IN FMOC-SOLID PHASE PEPTIDE-SYNTHESIS
  publication-title: TETRAHEDRON LETTERS
  contributor:
    fullname: GRAMBERG, D
– volume: 7
  start-page: 125
  year: 2003
  ident: WOS:000207200600005
  article-title: Microwave-enhanced transition metal-catalyzed decoration of 2(1H)-pyrazinone scaffolds
  publication-title: MOLECULAR DIVERSITY
  contributor:
    fullname: Kaval, N
– volume: 5
  start-page: 560
  year: 2003
  ident: WOS:000185247200003
  article-title: An exploratory study on microwave-assisted solid-phase Diels-Alder reactions of 2(1H)-pyrazinones: the elaboration of a new tailor-made acid-labile linker
  publication-title: JOURNAL OF COMBINATORIAL CHEMISTRY
  doi: 10.1021/cc0300098
  contributor:
    fullname: Kaval, N
– volume: 43
  start-page: 447
  year: 2002
  ident: WOS:000173262000026
  article-title: Stereoselective intramolecular Diels-Alder reactions of 3-alkenyl(oxy)-2(1H)-pyrazinones
  publication-title: TETRAHEDRON LETTERS
  contributor:
    fullname: De Borggraeve, WM
– volume: 49
  start-page: 2286
  year: 1984
  ident: WOS:A1984SW65900042
  article-title: AN EFFICIENT SYNTHESIS OF ETHYL LL-3-AMINO-2-PIPERIDONE-6-CARBOXYLATE
  publication-title: JOURNAL OF ORGANIC CHEMISTRY
  contributor:
    fullname: KEMP, DS
– volume: 286
  start-page: 1
  year: 2000
  ident: WOS:000165201200001
  article-title: Prediction of tight turns and their types in proteins
  publication-title: ANALYTICAL BIOCHEMISTRY
  doi: 10.1006/abio.2000.4757
  contributor:
    fullname: Chou, KC
– volume: 54
  start-page: 13211
  year: 1998
  ident: WOS:000076290600019
  article-title: Synthesis of alpha-carbolines and beta-carbolinones via intramolecular Diels-Alder reactions of 2(1H)-pyrazinones
  publication-title: TETRAHEDRON
  contributor:
    fullname: Tahri, A
– volume: 286
  start-page: 291
  year: 1999
  ident: WOS:000078702000023
  article-title: Non-proline cis peptide bonds in proteins
  publication-title: JOURNAL OF MOLECULAR BIOLOGY
  contributor:
    fullname: Jabs, A
– volume: 59
  start-page: 5481
  year: 2003
  ident: WOS:000184164900013
  article-title: Diels-Alder reactions of pyridinone o-quinodimethanes generated from substituted sulfolene[3,4-c]pyridin-4(1H)-ones
  publication-title: TETRAHEDRON
  doi: 10.1016/S0040-4020(03)00826-3
  contributor:
    fullname: Govaerts, TC
– start-page: 824
  year: 1970
  ident: WOS:000225148000031.25
  publication-title: CHEM AMIDES
  contributor:
    fullname: PATAI S
– volume: 45
  start-page: 4371
  year: 2004
  ident: WOS:000221564200039
  article-title: Acid catalysed methanolysis of 2,5-diazabicyclo[2.2.2]octane-3,6-diones: scope and limitations
  publication-title: TETRAHEDRON LETTERS
  doi: 10.1016/j.tetlet.2004.03.186
  contributor:
    fullname: Verbist, BMP
– volume: 45
  start-page: 1885
  year: 2004
  ident: WOS:000189116200016
  article-title: New routes for the synthesis of 3-and 5-substituted 2(1H)-pyrazinones
  publication-title: TETRAHEDRON LETTERS
  doi: 10.1016/j.tetlet.2004.01.017
  contributor:
    fullname: Azzam, R
– volume: 113
  start-page: 1
  year: 1994
  ident: WOS:A1994NC25600001
  article-title: CONFORMATIONALLY RESTRICTED AMINO-ACIDS AND DIPEPTIDES, (NON)PEPTIDOMIMETICS AND SECONDARY STRUCTURE MIMETICS
  publication-title: RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS-JOURNAL OF THE ROYAL NETHERLANDS CHEMICAL SOCIETY
  contributor:
    fullname: LISKAMP, RMJ
– volume: 20
  start-page: 919
  year: 1983
  ident: WOS:A1983RE04100014
  article-title: A NEW SYNTHESIS OF SUBSTITUTED 2(1H)-PYRAZINONES
  publication-title: JOURNAL OF HETEROCYCLIC CHEMISTRY
  contributor:
    fullname: VEKEMANS, J
– volume: 53
  start-page: 12789
  year: 1997
  ident: WOS:A1997XW84000002
  article-title: Design and synthesis of conformationally constrained amino acids as versatile scaffolds and peptide mimetics
  publication-title: TETRAHEDRON
  contributor:
    fullname: Hanessian, S
– volume: 6
  start-page: 953
  year: 2004
  ident: WOS:000225148000031.13
  publication-title: J ORG LETT
  contributor:
    fullname: HOYE TR
– volume: 35
  start-page: 1493
  year: 1994
  ident: WOS:A1994MZ86100007
  article-title: DESIGN, SYNTHESIS AND EVALUATION OF A NOVEL BICYCLIC LACTAM AS A GLY-PRO TYPE-VI BETA-TURN MIMIC
  publication-title: TETRAHEDRON LETTERS
  contributor:
    fullname: DUMAS, JP
– volume: 51
  start-page: 12463
  year: 1995
  ident: WOS:A1995TD21800027
  article-title: INTRAMOLECULAR DIELS-ALDER REACTIONS OF 2(1H)-PYRAZINONES - SYNTHESIS OF NEW FURO/PYRANO-PYRIDINONES AND FURO/PYRANO-PYRIDINES
  publication-title: TETRAHEDRON
  contributor:
    fullname: BUYSENS, KJ
– volume: 42
  start-page: 7397
  year: 2001
  ident: WOS:000171456400017
  article-title: Intramolecular Diels-Alder reactions of N-alkenyl-2(1H)-pyrazinones: generation of a novel type of cis-1,7-naphthyridine
  publication-title: TETRAHEDRON LETTERS
  contributor:
    fullname: Rombouts, FJR
– volume: 3
  start-page: 55
  year: 1990
  ident: MEDLINE:2163268
  article-title: Conformational constraints: nonpeptide beta-turn mimics.
  publication-title: Journal of molecular recognition : JMR
  contributor:
    fullname: Ball, J B
– volume: 42
  start-page: 5693
  year: 2001
  ident: WOS:000170309700025
  article-title: Synthesis of a conformationally restricted dipeptide analogue and its evaluation as a beta-turn mimic
  publication-title: TETRAHEDRON LETTERS
  contributor:
    fullname: De Borggraeve, WM
– volume: 23
  start-page: 3759
  year: 1982
  ident: WOS:A1982PE98500006
  article-title: AMINO-ACID DERIVATIVES THAT STABILIZE SECONDARY STRUCTURES OF POLYPEPTIDES .1. SYNTHESIS OF LL-3-AMINO-2-PIPERIDONE-6-CARBOXYLIC ACID (LL-ACP), A NOVEL BETA-TURN-FORMING AMINO-ACID
  publication-title: TETRAHEDRON LETTERS
  contributor:
    fullname: KEMP, DS
– start-page: 231
  year: 1996
  ident: WOS:A1996TU46300004
  article-title: Generation of 6-alkylidene/benzylidene-3,6-dihydropyrazin-2(1H)-ones by reaction of 6-bromomethylpyrazin-2(1H)-ones with methoxide and further conversion into specific piperazine-2,5-diones and pyrazin-2(1H)-ones
  publication-title: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
  contributor:
    fullname: Buysens, KJ
– volume: 2003
  start-page: 1868
  year: 2003
  ident: WOS:000183105000007
  article-title: Development of a functionalizable external beta-turn mimic based on a cis-fused 1,7-naphthyridine scaffold
  publication-title: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
  doi: 10.1002/ejoc.200200652
  contributor:
    fullname: Rombouts, FJR
– volume: 59
  start-page: 5047
  year: 2003
  ident: WOS:000183860800016
  article-title: Stereoselective transformation of pyrazinones into substituted analogues of cis-5-amino-6-oxo-2-piperidinemethanol and cis-5-amino-2-piperidinemethanol
  publication-title: TETRAHEDRON
  doi: 10.1016/S0040-4020(03)00741-5
  contributor:
    fullname: Rogiers, J
– volume: 23
  start-page: 3761
  year: 1982
  ident: WOS:A1982PE98500007
  article-title: AMINO-ACID DERIVATIVES THAT STABILIZE SECONDARY STRUCTURES OF POLYPEPTIDES .2. THE MOST STABLE CONFORMATION OF PEPTIDES CONTAINING 3-AMINO-2-PIPERIDONE-6-CARBOXYLIC ACID (ACP)
  publication-title: TETRAHEDRON LETTERS
  contributor:
    fullname: KEMP, DS
– volume: 120
  start-page: 5363
  year: 1998
  ident: WOS:000074213800002
  article-title: Conformational analysis of reverse-turn constraints by N-methylation and N-hydroxylation of amide bonds in peptides and non-peptide mimetics
  publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
  contributor:
    fullname: Takeuchi, Y
– volume: 59
  start-page: 4721
  year: 2003
  ident: WOS:000183780900002
  article-title: Synthesis and conformational analysis of Substance P antagonist analogues based on a 1,7-naphthyridine scaffold
  publication-title: TETRAHEDRON
  doi: 10.1016/S0040-4020(03)00732-4
  contributor:
    fullname: Rombouts, FJR
– volume: 49
  start-page: 3467
  year: 1993
  ident: WOS:A1993LA10200004
  article-title: BETA-TURN TOPOGRAPHY
  publication-title: TETRAHEDRON
  contributor:
    fullname: BALL, JB
– volume: 7
  start-page: 945
  year: 2000
  ident: WOS:000088981000006
  article-title: Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads
  publication-title: CURRENT MEDICINAL CHEMISTRY
  contributor:
    fullname: Hruby, VJ
– volume: 23
  start-page: 3761
  year: 1982
  ident: 10.1016/j.tet.2004.09.054_bib6_1
  publication-title: Tetrahedron Lett.
  doi: 10.1016/S0040-4039(00)87700-X
  contributor:
    fullname: Kemp
– volume: 286
  start-page: 291
  year: 1999
  ident: 10.1016/j.tet.2004.09.054_bib1_2
  publication-title: J. Mol. Biol.
  doi: 10.1006/jmbi.1998.2459
  contributor:
    fullname: Jabs
– volume: 49
  start-page: 2286
  year: 1984
  ident: 10.1016/j.tet.2004.09.054_bib6_2
  publication-title: J. Org. Chem.
  doi: 10.1021/jo00186a042
  contributor:
    fullname: Kemp
– volume: 59
  start-page: 5047
  year: 2003
  ident: 10.1016/j.tet.2004.09.054_bib21
  publication-title: Tetrahedron
  doi: 10.1016/S0040-4020(03)00741-5
  contributor:
    fullname: Rogiers
– volume: 113
  start-page: 1
  year: 1994
  ident: 10.1016/j.tet.2004.09.054_bib3_3
  publication-title: Recl. Trav. Chim. Pays-Bas.
  doi: 10.1002/recl.19941130102
  contributor:
    fullname: Liskamp
– volume: 42
  start-page: 5693
  year: 2001
  ident: 10.1016/j.tet.2004.09.054_bib14
  publication-title: Tetrahedron Lett.
  doi: 10.1016/S0040-4039(01)01080-2
  contributor:
    fullname: De Borggraeve
– year: 1970
  ident: 10.1016/j.tet.2004.09.054_bib22
  contributor:
    fullname: Pataï
– volume: 7
  start-page: 945
  year: 2000
  ident: 10.1016/j.tet.2004.09.054_bib3_1
  publication-title: Curr. Med. Chem.
  doi: 10.2174/0929867003374499
  contributor:
    fullname: Hruby
– volume: 5
  start-page: 676
  year: 1998
  ident: 10.1016/j.tet.2004.09.054_bib1_1
  publication-title: Nat. Struct. Biol.
  doi: 10.1038/1368
  contributor:
    fullname: Weiss
– volume: 43
  start-page: 447
  year: 2002
  ident: 10.1016/j.tet.2004.09.054_bib15_2
  publication-title: Tetrahedron Lett.
  doi: 10.1016/S0040-4039(01)02188-8
  contributor:
    fullname: De Borggraeve
– volume: 7
  start-page: 125
  year: 2003
  ident: 10.1016/j.tet.2004.09.054_bib15_10
  publication-title: Mol. Divers.
  doi: 10.1023/B:MODI.0000006807.43408.d5
  contributor:
    fullname: Kaval
– volume: 54
  start-page: 13211
  year: 1998
  ident: 10.1016/j.tet.2004.09.054_bib15_6
  publication-title: Tetrahedron
  doi: 10.1016/S0040-4020(98)00802-3
  contributor:
    fullname: Tahri
– volume: 6
  start-page: 953
  year: 2004
  ident: 10.1016/j.tet.2004.09.054_bib23
  publication-title: J. Org. Lett.
  doi: 10.1021/ol049979+
  contributor:
    fullname: Hoye
– volume: 286
  start-page: 1
  year: 2000
  ident: 10.1016/j.tet.2004.09.054_bib2
  publication-title: Anal. Biochem.
  doi: 10.1006/abio.2000.4757
  contributor:
    fullname: Chou
– volume: 5
  start-page: 560
  year: 2003
  ident: 10.1016/j.tet.2004.09.054_bib15_9
  publication-title: J. Comb. Chem.
  doi: 10.1021/cc0300098
  contributor:
    fullname: Kaval
– volume: 35
  start-page: 1493
  year: 1994
  ident: 10.1016/j.tet.2004.09.054_bib7_1
  publication-title: Tetrahedron Lett.
  doi: 10.1016/S0040-4039(00)76740-2
  contributor:
    fullname: Dumas
– volume: 11
  start-page: 440
  year: 1990
  ident: 10.1016/j.tet.2004.09.054_bib10
  publication-title: J. Comput. Chem.
  doi: 10.1002/jcc.540110405
  contributor:
    fullname: Mohamadi
– volume: 23
  start-page: 3759
  year: 1982
  ident: 10.1016/j.tet.2004.09.054_bib6_3
  publication-title: Tetrahedron Lett.
  doi: 10.1016/S0040-4039(00)87699-6
  contributor:
    fullname: Kemp
– volume: 61
  start-page: 3138
  year: 1996
  ident: 10.1016/j.tet.2004.09.054_bib7_2
  publication-title: J. Org. Chem.
  doi: 10.1021/jo960012w
  contributor:
    fullname: Kim
– volume: 59
  start-page: 4721
  year: 2003
  ident: 10.1016/j.tet.2004.09.054_bib15_4
  publication-title: Tetrahedron
  doi: 10.1016/S0040-4020(03)00732-4
  contributor:
    fullname: Rombouts
– volume: 20
  start-page: 919
  year: 1983
  ident: 10.1016/j.tet.2004.09.054_bib13
  publication-title: J. Heterocycl. Chem.
  doi: 10.1002/jhet.5570200414
  contributor:
    fullname: Vekemans
– volume: 51
  start-page: 12463
  year: 1995
  ident: 10.1016/j.tet.2004.09.054_bib15_7
  publication-title: Tetrahedron
  doi: 10.1016/0040-4020(95)00802-F
  contributor:
    fullname: Buysens
– volume: 45
  start-page: 4371
  year: 2004
  ident: 10.1016/j.tet.2004.09.054_bib20
  publication-title: Tetrahedron Lett.
  doi: 10.1016/j.tetlet.2004.03.186
  contributor:
    fullname: Verbist
– volume: 45
  start-page: 1885
  year: 2004
  ident: 10.1016/j.tet.2004.09.054_bib15_1
  publication-title: Tetrahedron Lett.
  doi: 10.1016/j.tetlet.2004.01.017
  contributor:
    fullname: Azzam
– start-page: 1868
  year: 2003
  ident: 10.1016/j.tet.2004.09.054_bib9_1
  publication-title: Eur. J. Org. Chem.
  doi: 10.1002/ejoc.200200652
  contributor:
    fullname: Rombouts
– volume: 67
  start-page: 7904
  year: 2002
  ident: 10.1016/j.tet.2004.09.054_bib19
  publication-title: J. Org. Chem.
  doi: 10.1021/jo0263216
  contributor:
    fullname: Van der Eycken
– volume: 53
  start-page: 12789
  year: 1997
  ident: 10.1016/j.tet.2004.09.054_bib3_2
  publication-title: Tetrahedron
  doi: 10.1016/S0040-4020(97)00298-6
  contributor:
    fullname: Hanessian
– volume: 49
  start-page: 3577
  year: 1993
  ident: 10.1016/j.tet.2004.09.054_bib5
  publication-title: Tetrahedron
  doi: 10.1016/S0040-4020(01)90216-9
  contributor:
    fullname: Nagai
– volume: 59
  start-page: 5481
  year: 2003
  ident: 10.1016/j.tet.2004.09.054_bib15_5
  publication-title: Tetrahedron
  doi: 10.1016/S0040-4020(03)00826-3
  contributor:
    fullname: Govaerts
– volume: 35
  start-page: 861
  year: 1994
  ident: 10.1016/j.tet.2004.09.054_bib8
  publication-title: Tetrahedron Lett.
  doi: 10.1016/S0040-4039(00)75983-1
  contributor:
    fullname: Gramberg
– volume: 120
  start-page: 5363
  year: 1998
  ident: 10.1016/j.tet.2004.09.054_bib9_2
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja970855k
  contributor:
    fullname: Takeuchi
– volume: 49
  start-page: 3467
  year: 1993
  ident: 10.1016/j.tet.2004.09.054_bib11
  publication-title: Tetrahedron
  doi: 10.1016/S0040-4020(01)90207-8
  contributor:
    fullname: Ball
– volume: 42
  start-page: 7397
  year: 2001
  ident: 10.1016/j.tet.2004.09.054_bib15_3
  publication-title: Tetrahedron Lett.
  doi: 10.1016/S0040-4039(01)01545-3
  contributor:
    fullname: Rombouts
– ident: 10.1016/j.tet.2004.09.054_bib12
– volume: 3
  start-page: 55
  year: 1990
  ident: 10.1016/j.tet.2004.09.054_bib4
  publication-title: J. Mol. Recognit.
  doi: 10.1002/jmr.300030202
  contributor:
    fullname: Ball
– start-page: 231
  year: 1996
  ident: 10.1016/j.tet.2004.09.054_bib15_8
  publication-title: J. Chem. Soc., Perkin Trans. 1
  doi: 10.1039/p19960000231
  contributor:
    fullname: Buysens
SSID ssj0001123
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Snippet In this paper, a synthetic approach for functionalised 5-aminopiperidinone-2-carboxylate (APC) systems as non-pro cis-peptide bond containing external β-turn...
In this paper, a synthetic approach for functionalised 5-aminopiperidinone-2-carboxylate (APC) systems as non-pro cis-peptide bond containing external...
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SubjectTerms Chemistry
Chemistry, Organic
Diels–Alder reaction
Physical Sciences
Pyrazinone
Science & Technology
Turn mimics
Title Design and synthesis of novel type VI-like β-turn mimetics. Diversity at the i+1 and the i+2 position
URI https://dx.doi.org/10.1016/j.tet.2004.09.054
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