Cyclin D1b Splice Variant Promotes αvβ3-mediated EMT Induced by LPS in Breast Cancer Cells

• Published in: Current medical science Vol. 38; no. 3; pp. 467 - 472
• Main Authors: Luo, Bao-ping, Luo, Jing, Hu, Yi-bing, Yao, Xiao-wei, Wu, Feng-hua
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.06.2018; Department of Tumor, Hubei Provincial Hospital of Traditional Chinese Medicine/The First Clinic College, Hubei University of Chinese Medicine, Wuhan 430065, China%Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430032,China%Department of Physiology, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065,China
• Subjects: Medicine; Medicine & Public Health; breast cancer; lipopolysaccharide; cyclin D1b; epithelial-to-mesenchymal transition; αvβ3- integrin; αvβ3-integrin

Summary Epithelial-to-mesenchymal transition (EMT) plays a critical role in cancer metastasis, and is relevant to the inflammatory microenvironment. Lipopolysaccharide (LPS), a cell wall constituent of gram-negative bacteria, has been reported to induce EMT of cancer cells through TLR4 signal. We pr...