Enhancement of Cholesterol Esterification in Macrophages by Platelets' Secretory Products

Macrophages derived foam cells and platelets are found in many lesions of atherosclerosis. The object of the study is to evaluate the effect of platelets' secretory products on foam cell formation of macrophages. Firstly, we got two kinds of platelet free supernatants, which one is prepared fro...

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Published inDōmyaku kōka = The Journal of Japan Atherosclerosis Society Vol. 16; no. 3; pp. 391 - 393
Main Authors HAYASHI, Toshio, NAITO, Michitaka, KUZUYA, Masafumi, FUNAKI, Chiaki, ASAI, Kanichi, KUZUYA, Fumio
Format Journal Article
LanguageEnglish
Published Japan Atherosclerosis Society 1988
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Abstract Macrophages derived foam cells and platelets are found in many lesions of atherosclerosis. The object of the study is to evaluate the effect of platelets' secretory products on foam cell formation of macrophages. Firstly, we got two kinds of platelet free supernatants, which one is prepared from platelets rich plasma frozen and thawed three times (PSPα), another one from thrombin activated platelets (PSPβ). We studied whether these supernatants and other platelets' secretory products (PDGF, STA2, and SEROTONIN) enhanced macrophages lipid storage or not by using a microscale enzymatic assay system. PSPα, PSPβ and PDGF enhanced esterified cholesterol accumulation. We supposed that platelets contributed to the lipid storage of macrophages in developing atherosclerosis.
AbstractList Macrophages derived foam cells and platelets are found in many lesions of atherosclerosis. The object of the study is to evaluate the effect of platelets' secretory products on foam cell formation of macrophages. Firstly, we got two kinds of platelet free supernatants, which one is prepared from platelets rich plasma frozen and thawed three times (PSPα), another one from thrombin activated platelets (PSPβ). We studied whether these supernatants and other platelets' secretory products (PDGF, STA2, and SEROTONIN) enhanced macrophages lipid storage or not by using a microscale enzymatic assay system. PSPα, PSPβ and PDGF enhanced esterified cholesterol accumulation. We supposed that platelets contributed to the lipid storage of macrophages in developing atherosclerosis.
Author KUZUYA Masafumi
ASAI Kanichi
HAYASHI Toshio
FUNAKI Chiaki
NAITO Michitaka
KUZUYA Fumio
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  organization: Department of Geriatrics, Nagoya University School of Medicine
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PublicationTitle Dōmyaku kōka = The Journal of Japan Atherosclerosis Society
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Title Enhancement of Cholesterol Esterification in Macrophages by Platelets' Secretory Products
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