Oral Olanzapine Disposition in Adolescents with Schizophrenia or Bipolar I Disorder A Population Pharmacokinetic Model

• Published in: Paediatric drugs Vol. 12; no. 3; pp. 201 - 211
• Main Authors: Lobo, Evelyn D., Robertson-Plouch, Carol, Quinlan, Tonya, Hong, Quan, Bergstrom, Richard F.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2010; Wolters Kluwer Health, Inc; Springer Nature B.V
• Subjects: Bipolar disorder; Dosage and administration; Drug therapy; Internal Medicine; Medicine; Medicine & Public Health; Olanzapine; Original Research Article; Pediatrics; Pharmacokinetics; Pharmacotherapy; Schizophrenia; United States; Oral Olanzapine; Olanzapine; Population Pharmacokinetic Model; Interpatient Variability; Parameter Sensitivity Analysis

Background Olanzapine is an atypical antipsychotic approved for the treatment of adults and adolescents (aged 13–17 years) with schizophrenia or bipolar I disorder (manic or mixed episodes). Objectives To characterize the pharmacokinetics of olanzapine in adolescents, to estimate the sources of vari...