Readministration of adenoviral gene delivery to dopamine neurons

• Published in: Neuroreport Vol. 18; no. 15; p. 1609
• Main Authors: Gonzalez, Sarah C, McMenamin, Margaret M, Charlton, Harry M, Goodman, James, Lantos, Tibor, Simpson, Christine, Wood, Matthew J A
• Format: Journal Article
• Language: English
• Published: England 08.10.2007
• Subjects: Adenoviridae - genetics; Animals; DNA, Viral - biosynthesis; DNA, Viral - genetics; Dopamine - physiology; Gene Transfer Techniques; Genetic Vectors - administration & dosage; Humans; Immunohistochemistry; Lac Operon - genetics; Mice; Mice, Inbred C3H; Microinjections; Neurons - physiology; Reverse Transcriptase Polymerase Chain Reaction; Stereotaxic Techniques; Substantia Nigra - physiology; Transgenes - physiology

An approach currently being explored as treatment for Parkinson's disease is gene therapy. An important question concerns the duration of transgene expression in dopamine neurons and the issues of vector persistence, neuronal damage and the feasibility of readministering vector to the same neur...