Stopping power and range estimations in proton therapy based on prompt gamma timing: motion models and automated parameter optimization

• Published in: Physics in medicine & biology Vol. 69; no. 14; pp. 14 - 21
• Main Authors: Werner, Julius, Pennazio, Francesco, Schmid, Niklas, Fiorina, Elisa, Bersani, Davide, Cerello, Piergiorgio, Kasprzak, Jona, Mosco, Nicola, Ranjbar, Sahar, Sacchi, Roberto, Ferrero, Veronica, Rafecas, Magdalena
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 15.07.2024
• Subjects: Automation; Gamma Rays; Monte Carlo Method; Monte-Carlo simulations; optimization; Phantoms, Imaging; prompt gamma timing; proton therapy; Proton Therapy - methods; Radiotherapy Planning, Computer-Assisted - methods; range monitoring; stopping power; Time Factors; treatment verification; proton therapy; optimization; treatment verification; range monitoring; Monte-Carlo simulations; stopping power; prompt gamma timing

Particle therapy treatments are currently limited by uncertainties of the delivered dose. Verification techniques like Prompt-Gamma-Timing-based Stopping Power Estimation (PGT-SPE) may allow for reduction of safety margins in treatment planning. From Prompt-Gamma-Timing measurements, we reconstruct...