Increased circulating resistin is associated with insulin resistance, oxidative stress and platelet activation in type 2 diabetes mellitus

• Published in: Thrombosis and haemostasis Vol. 116; no. 6; p. 1089
• Main Authors: Santilli, Francesca, Liani, Rossella, Di Fulvio, Patrizia, Formoso, Gloria, Simeone, Paola, Tripaldi, Romina, Ueland, Thor, Aukrust, Pål, Davì, Giovanni
• Format: Journal Article
• Language: English
• Published: Germany 01.12.2016
• Subjects: Aged; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - blood; Female; Humans; Hyperglycemia; Insulin Resistance; Male; Middle Aged; Oxidative Stress; Platelet Activation; Resistin - blood; adipokine; insulin resistance; Diabetes mellitus; oxidative stress; platelet activation

Resistin is an adipokine that promotes inflammation and insulin resistance by targeting several cells including platelets. We hypothesised that in type 2 diabetes (T2DM), resistin may foster in vivo oxidative stress, thromboxane-dependent platelet activation and platelet-derived inflammatory protein...