Glypican-4 trajectory predicts the risk of gestational diabetes mellitus and the requirement for insulin therapy during pregnancy

• Published in: Frontiers in endocrinology (Lausanne) Vol. 16; p. 1483567
• Main Authors: Tang, Lei, Li, Ping, Li, Ling
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 21.03.2025
• Subjects: Adult; Biomarkers - blood; Blood Glucose - analysis; Blood Glucose - metabolism; Diabetes, Gestational - blood; Diabetes, Gestational - diagnosis; Diabetes, Gestational - drug therapy; Female; gestational diabetes mellitus; Glucose Tolerance Test; glypican-4; Glypicans - blood; Humans; Hypoglycemic Agents - therapeutic use; Insulin - therapeutic use; insulin therapy; oral glucose tolerance test; postpartum glucose metabolism; Pregnancy; Risk Factors; oral glucose tolerance test; gestational diabetes mellitus; glypican-4; insulin therapy; postpartum glucose metabolism

Gestational diabetes mellitus (GDM), characterized by the onset of glucose intolerance during pregnancy, results in a series of complications for maternal and fetal health. Oral glucose tolerance test (OGTT) for screening glucose metabolism is performed in mid-to-late pregnancy, which remains less t...