The Prognostic Significance of Mast Cell Count in Soft Tissue Sarcomas
Mast cells (MC) are known to play an important role in IgE-dependent allergic reaction, host defense against parasite infestation, local hemostasis, inflammation, and angiogenesis. The significance of MC in tumor surveillance has been studied with conflicting results. The presence of MC in tumor has...
Saved in:
| Published in | International journal of surgical pathology Vol. 7; no. 3; pp. 141 - 148 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Thousand Oaks, CA
SAGE Publications
01.07.1999
SAGE PUBLICATIONS, INC |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Mast cells (MC) are known to play an important role in IgE-dependent allergic reaction, host defense against parasite infestation, local hemostasis, inflammation, and angiogenesis. The significance of MC in tumor surveillance has been studied with conflicting results. The presence of MC in tumor has been described as evidence of a host immunologic antitumor response, and a high count of tumor-associated MC has been considered as a favorable prognostic factor in sarcomas. In other studies, MC have been shown to have an adverse role in neoplastic proliferation. In this study, tumor-associated MC were histologically quantitated in 75 soft tissue sarcomas. We found that soft tissue sarcomas with a higher MC count (n=or>six) were associated with significant better survival and relatively low incidence of metastasis in contrast to those with a lower count (n<six). There was no correlation between MC count and the histologic type, grade, or size of the sarcomas. Although the role of mast cells in tumor surveillance is still under investigation, quantitive assessment of tumorassociated MC on routine histologic sections could be used as an additional prognostic factor in soft tissue sarcomas. |
|---|---|
| AbstractList | Mast cells (MC) are known to play an important role in IgE-dependent allergic reaction, host defense against parasite infestation, local hemostasis, inflammation, and angiogenesis. The significance of MC in tumor surveillance has been studied with conflicting results. The presence of MC in tumor has been described as evidence of a host immunologic antitumor response, and a high count of tumor-associated MC has been considered as a favorable prognostic factor in sarcomas. In other studies, MC have been shown to have an adverse role in neoplastic proliferation. In this study, tumor-associated MC were histologically quantitated in 75 soft tissue sarcomas. We found that soft tissue sarcomas with a higher MC count (n=or>six) were associated with significant better survival and relatively low incidence of metastasis in contrast to those with a lower count (n<six). There was no correlation between MC count and the histologic type, grade, or size of the sarcomas. Although the role of mast cells in tumor surveillance is still under investigation, quantitive assessment of tumorassociated MC on routine histologic sections could be used as an additional prognostic factor in soft tissue sarcomas. |
| Author | Zhang, Paul J. Kobos, Jozef W. Brooks, John J. |
| Author_xml | – sequence: 1 givenname: Paul J. surname: Zhang fullname: Zhang, Paul J. organization: Division of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY – sequence: 2 givenname: Jozef W. surname: Kobos fullname: Kobos, Jozef W. organization: Medical University of LodY, Poland – sequence: 3 givenname: John J. surname: Brooks fullname: Brooks, John J. organization: Division of Pathology & Laboratory Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263 |
| BookMark | eNp9kE1LAzEURYNUsK3-AVfBhbuxL58zWcpgVagodPZDmiY1pU3qZGbhvzelgqDg6r3FOZfLnaBRiMEidE3gjpCynBGQslJSKQVQAjBgZ2hMFIeCcilG-c9AcSQu0CSlLQBQSckYzZt3i9-6uAkx9d7gpd8E77zRwVgcHX7Rqce13e1wHYfQYx_wMroeNz6lweKl7kzc63SJzp3eJXv1faeomT809VOxeH18ru8XhaGK9wWnZeksYZpaDXq1cqKqHLNcuhW4ygkhOVVrAVqUkrKKgODGCLY2TAtLKjZFt6fYQxc_Bpv6du-Tye10sHFILSVECa4ggze_wG0cupCrZYaTKm8kMkRPkOliSp117aHze919tgTa46zt31mzNDtJSW_sT-o_xhed0neH |
| CODEN | IJSPFL |
| Cites_doi | 10.1093/ajcp/89.3.335 10.1084/jem.152.4.931 10.1038/365340a0 10.1111/1523-1747.ep12475169 10.1111/j.1365-2222.1991.tb01757.x 10.1084/jem.153.3.520 10.1172/JCI114344 10.1016/0006-291X(84)90470-4 10.1038/bjc.1961.41 10.1002/path.1711480208 10.1038/293103a0 10.1080/09553009114552021 10.1002/path.1711620204 10.1002/path.1711340103 10.1111/j.2517-6161.1972.tb00899.x 10.1016/0008-8749(80)90162-8 10.1002/1097-0142(197710)40:4<1562::AID-CNCR2820400428>3.0.CO;2-6 10.1080/01621459.1958.10501452 10.1164/ajrccm/142.4.863 10.1002/ijc.2910420110 10.1002/ijc.2910180520 10.1002/1097-0142(19840201)53:3<530::AID-CNCR2820530327>3.0.CO;2-D 10.1016/S0344-0338(85)80184-9 10.1007/BF00119080 10.1016/0167-5699(90)90176-A 10.1038/bjc.1991.192 |
| ContentType | Journal Article |
| Copyright | Copyright Westminster Publications, Inc. Jul 1999 |
| Copyright_xml | – notice: Copyright Westminster Publications, Inc. Jul 1999 |
| DBID | AAYXX CITATION 3V. 7X7 7XB 88E 88I 8AF 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. M0S M1P M2P PQEST PQQKQ PQUKI PRINS Q9U 7T5 H94 |
| DOI | 10.1177/106689699900700303 |
| DatabaseName | CrossRef ProQuest Central (Corporate) Health & Medical Complete (ProQuest Database) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Science Database (Alumni Edition) STEM Database Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials AUTh Library subscriptions: ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest Science Journals ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Immunology Abstracts AIDS and Cancer Research Abstracts |
| DatabaseTitle | CrossRef ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest AP Science ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) AIDS and Cancer Research Abstracts Immunology Abstracts |
| DatabaseTitleList | CrossRef AIDS and Cancer Research Abstracts |
| Database_xml | – sequence: 1 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1940-2465 |
| EndPage | 148 |
| ExternalDocumentID | 48771670 10_1177_106689699900700303 10.1177_106689699900700303 |
| GroupedDBID | --- -MK -TM .2E .2F .2G .2J .2N 01A 0R~ 18M 1~K 29J 31R 31S 31U 31X 31Y 31Z 36B 3V. 4.4 53G 54M 5GY 5VS 7X7 88E 88I 8AF 8FI 8FJ 8R4 8R5 AABMB AACKU AACMV AACTG AADTT AADUE AAEWN AAGGD AAGMC AAJIQ AAJOX AAJPV AAKGS AAMGE AANSI AAPEO AAQDB AAQXH AARDL AARIX AATAA AATBZ AAUAS AAXOT AAYTG AAZBJ ABAWP ABCCA ABDWY ABEIX ABFWQ ABHKI ABHQH ABJIS ABJNI ABKRH ABLUO ABPGX ABPNF ABQKF ABQXT ABRHV ABUWG ABVFX ABVVC ABYTW ACARO ACDSZ ACDXX ACFEJ ACFMA ACFYK ACGBL ACGFO ACGFS ACGOD ACGZU ACJTF ACLFY ACLHI ACLZU ACOFE ACOXC ACROE ACSBE ACSIQ ACTQU ACUAV ACUIR ACXKE ACXMB ADBBV ADEIA ADMPF ADNBR ADRRZ ADTBJ ADUKL ADZZY AECGH AECVZ AEDTQ AEGXH AEKYL AENEX AEPTA AEQLS AERKM AESZF AEUHG AEUIJ AEWDL AEWHI AEXFG AEXNY AFEET AFKBI AFKRA AFKRG AFMOU AFQAA AFUIA AGKLV AGNHF AGWFA AHHFK AHMBA AIAGR AIGRN AIIQI AIOMO AJABX AJEFB AJMMQ AJSCY AJUZI AJXAJ ALIPV ALJHS ALMA_UNASSIGNED_HOLDINGS ALTZF AMCVQ ANDLU ARTOV ASPBG AUTPY AUVAJ AVWKF AYAKG AZFZN AZQEC B3H B8M B8O B8R B8Z B93 B94 BBRGL BDDNI BENPR BKIIM BKSCU BPACV BPHCQ BSEHC BVXVI BWJAD C45 CAG CBRKF CCPQU CDWPY CFDXU COF CORYS CQQTX CS3 CUTAK DB0 DC- DC0 DD- DD0 DE- DF0 DO- DOPDO DU5 DV7 DV9 DWQXO D~Y EBC EBD EBS EHN EJD EMB EMOBN EPT F5P FEDTE FHBDP FYUFA GNUQQ GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION HCIFZ HF~ HMCUK HVGLF HZ~ J8X JCYGO K.F K.J M1P M2P M2Q M4V N9A O9- OVD P.B P2P PQQKQ PROAC PSQYO Q1R Q2X Q7K Q7L Q7R Q7U Q7X Q82 Q83 Q~Q ROL RWL RXW S01 SCNPE SDB SFB SFC SFK SFN SFT SGA SGO SGP SGR SGV SGX SGZ SHG SNB SPJ SPQ SPV SQCSI STM SV3 TAE TEORI UKHRP ZONMY ZPPRI ZRKOI ZSSAH AAYXX ACJER ALKWR CITATION H13 7XB 8FK AGWNL K9. PQEST PQUKI PRINS Q9U 7T5 H94 |
| ID | FETCH-LOGICAL-c294t-4277fe13a2ea0abbf588f3e46fb0f8f556429d50a5762381054cc53dc3a5e183 |
| IEDL.DBID | BENPR |
| ISSN | 1066-8969 |
| IngestDate | Sun Sep 29 07:38:19 EDT 2024 Thu Oct 10 17:38:17 EDT 2024 Wed Sep 25 14:08:54 EDT 2024 Tue Jul 16 20:45:14 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | mast cell count sarcoma Giemsa stain prognosis |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c294t-4277fe13a2ea0abbf588f3e46fb0f8f556429d50a5762381054cc53dc3a5e183 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| PQID | 214187005 |
| PQPubID | 30171 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_21195490 proquest_journals_214187005 crossref_primary_10_1177_106689699900700303 sage_journals_10_1177_106689699900700303 |
| PublicationCentury | 1900 |
| PublicationDate | 1999-07-01 |
| PublicationDateYYYYMMDD | 1999-07-01 |
| PublicationDate_xml | – month: 07 year: 1999 text: 1999-07-01 day: 01 |
| PublicationDecade | 1990 |
| PublicationPlace | Thousand Oaks, CA |
| PublicationPlace_xml | – name: Thousand Oaks, CA – name: Glen Head |
| PublicationTitle | International journal of surgical pathology |
| PublicationYear | 1999 |
| Publisher | SAGE Publications SAGE PUBLICATIONS, INC |
| Publisher_xml | – name: SAGE Publications – name: SAGE PUBLICATIONS, INC |
| References | Farram E, Nelson DS 1980; 55 Ehrlich P 1879; 3 Djukanovic R, Wilson JW, Britten KM, Wilson SJ, Walls AF, Roche WR, Howarth PH, Holgate ST 1990; 142 Fisher ER, Fisher B 1965; 79 Dabbous MKH, Haney L, Nicolson GL, Eckley D, Wooley DE 1991; 63 Tanooka H, Kitamura Y, Sado T, Tanaka K, Nagase M, Kondo S 1982; 69 Gauchat JF, Henchoz S, Mazzei G, Aurby JP, Brunner T, Blasey H, Life P, Talabot D, Flores-Romo L, Thompson J, Kishi K, Butterfield J, Dahinden C, Bonnefoy JY 1993; 365 Azizkhan RG, Azizkhan JC, Zetter BR, Folkman J 1980; 152 Dabbous MK, Wooley DE, Haney J, Carter LM, Nicolson GL 1986; 4 Gruber BL, Marchase MJ, Suzuki K, Schwartz LB, Okada Y, Nagase H, Ramamurthy NS 1989; 84 Ueda T, Aozasa K, Tsujimoto M, Yoshikawa H, Kato T, Ono K, Matsumoto K 1988; 64 Starkey JR, Crowe PK, Taubenburger S 1988; 42 Cox DR 1972; 34 Toffe JR, Taylor DJ, Woolley DE 1984; 122 Claman HN, On scleroderma 1989; 464 Hendersin WR, Chi EY, Long EC, Klebanoff SJ 1981; 153 Burtin C, Ponvert C, Fray A 1985; 74 Ionov ID 1991; 60 Csaba G, Acs T, Horvath C, Mold K 1961; 15 Hartveit F, Thoresen S, Tangen M, Maartmann-Moe H 1984; 4 Donhuijsen K, Sastry M, Volker B, Leder LD 1994; 188 Costa J, Wesley RA, Glatstein E, Rosenberg SA 1984; 53 Roche WR 1986; 148 Ionov ID 1989; 2 Holgren H, Wohlfart G 1947; 7 Kaminer MS, Lavker RM, Walsh LJ, Whitaker D, Zweiman B, Murphy GF 1991; 96 Walls AF, Jones DB, Williams JH, Church MK, Holgate ST 1990; 164 Horny HP, Reimann O, Kaiserling E 1988; 89 Hartveit F 1981; 134 Graham RM, Graham JB 1966; 123 Roche WR 1985; 119 Parwaresch MR, Horny HP, Lennart K 1985; 179 Russell WO, Cohen J, Enzinger F, Hajdu SI, Heise H, Martin RG, Meissner W, Miller WT, Schmitz RL, Suit HD 1977; 40 Kaplan EL, Meier P 1958; 53 Gordon JR, Parris RB, Galli SJ 1990; 11 Lewis RA, Austen KF 1981; 293 Kessker DA, Langer RS, Pless NA, Folkman J 1976; 18 Church MK, El-Lati S, Okayama Y 1991; 41 Sylven B 1945; 59 Fisher ER (atypb17) 1965; 79 Roche WR (atypb25) 1985; 119 atypb8 Donhuijsen K (atypb33) 1994; 188 Ionov ID (atypb10) 1989; 2 Ueda T (atypb12) 1988; 64 Cotran RS (atypb1) 1994 atypb19 Burtin C (atypb20) 1985; 74 Hartveit F (atypb22) 1984; 4 atypb26 atypb27 Sylven B (atypb28) 1945; 59 atypb29 Holgren H (atypb32) 1947; 7 Westphal E (atypb11) 1891 Tanooka H (atypb16) 1982; 69 atypb23 atypb24 atypb40 atypb41 atypb42 atypb21 atypb43 Ehrlich P (atypb9) 1879; 3 Graham RM (atypb18) 1966; 123 Enzinger FM (atypb34) 1994 atypb37 Ewing J (atypb15) 1928 Cox DR (atypb38) 1972; 34 atypb39 atypb13 atypb35 atypb14 atypb36 atypb30 atypb3 atypb31 atypb2 atypb4 Claman HN (atypb5) 1989; 464 atypb7 atypb6 |
| References_xml | – volume: 2 start-page: 204 year: 1989 end-page: 212 article-title: Mast-cell-basophil system in tumor growth publication-title: Neurofibromatosis contributor: fullname: Ionov ID – volume: 123 start-page: 3 year: 1966 end-page: 9 article-title: Mast cells and cancer of the cervix publication-title: Surg Gynecol Obstet contributor: fullname: Graham JB – volume: 74 start-page: 671 year: 1985 end-page: 674 article-title: Inverse correlation between tumor incidence and tissue histamine levels in W/Wv, Wv/+, and +/+ mice publication-title: J Natl Cancer Inst contributor: fullname: Fray A – volume: 188 start-page: 61 year: 1994 end-page: 66 article-title: Mast cell frequency in soft tissue tumors publication-title: Relation to type and gr.de of malignancy. Pathol Res Pract contributor: fullname: Leder LD – volume: 15 start-page: 327 year: 1961 end-page: 335 article-title: Genesis and function of mast cells. Mast cell and plasmacyte reaction to induced, homologous and heterologous tumors publication-title: Br J Cancer contributor: fullname: Mold K – volume: 40 start-page: 1562 year: 1977 end-page: 1570 article-title: A clinical and pathological staging system for soft tissue sarcomas publication-title: Cancer contributor: fullname: Suit HD – volume: 464 start-page: 671 year: 1989 end-page: 674 article-title: Mast cells, endothelial cells, and fibroblasts publication-title: JAMA contributor: fullname: On scleroderma – volume: 63 start-page: 873 year: 1991 end-page: 878 article-title: Mast cell modulation of tumor cell proliferation in rat mammary adenocarcinoma 13764NF publication-title: Br J Cancer contributor: fullname: Wooley DE – volume: 7 start-page: 686 year: 1947 end-page: 691 article-title: Mast cells in experimental rat sarcomas publication-title: Cancer Res contributor: fullname: Wohlfart G – volume: 4 start-page: 141 year: 1986 end-page: 141 article-title: Host mediated effectors of tumor invasion: Role of mast cells in matrix degradation publication-title: Clin Exp Metast contributor: fullname: Nicolson GL – volume: 179 start-page: 439 year: 1985 end-page: 439 article-title: Tissue mast cells in health and disease publication-title: Pathol Res Pract contributor: fullname: Lennart K – volume: 84 start-page: 1657 year: 1989 end-page: 1657 article-title: Synovial procollegenase activation by human mast cell tryptase. Dependence upon matrix metalloproteinase 3 activation publication-title: J Clin Invest contributor: fullname: Ramamurthy NS – volume: 64 start-page: 4416 year: 1988 end-page: 4419 article-title: Prognostic significance of mast cells in soft tissue sarcoma publication-title: Cancer contributor: fullname: Matsumoto K – volume: 55 start-page: 294 year: 1980 end-page: 301 article-title: Mouse mast cells as antitumor effector cells publication-title: Cell Immunol contributor: fullname: Nelson DS – volume: 42 start-page: 48 year: 1988 end-page: 48 article-title: Mast cell-deficient W/Wv mice exhibit a decreased rate of tumor angiogenesis publication-title: Int J Cancer contributor: fullname: Taubenburger S – volume: 53 start-page: 530 year: 1984 end-page: 541 article-title: The grading of soft tissue sarcomas. Results of a clinicohistopathologic correlation in a series of 163 cases publication-title: Cancer contributor: fullname: Rosenberg SA – volume: 293 start-page: 103 year: 1981 end-page: 103 article-title: Mediation of local hemostasis and inflammation by leukotrienes and other mast cell compounds publication-title: Nature contributor: fullname: Austen KF – volume: 142 start-page: 863 year: 1990 end-page: 871 article-title: Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry publication-title: Am Rev Respir Dis contributor: fullname: Holgate ST – volume: 122 start-page: 270 year: 1984 end-page: 270 article-title: Mast cell products stimulate collagenase and prostaglandin E production by cultures of adherent rheumatoid synovial cells publication-title: Biochem Biophys Res Commun contributor: fullname: Woolley DE – volume: 60 start-page: 487 year: 1991 end-page: 491 article-title: Inhibition of mast cell activity as a new approach to anticancer therapy publication-title: Int J Radiat Biol contributor: fullname: Ionov ID – volume: 59 start-page: 1 year: 1945 end-page: 99 article-title: Ester sulphuric acids of high molecular weight and mast cells in mesenchymal tumors publication-title: Acta Radiol contributor: fullname: Sylven B – volume: 11 start-page: 458 year: 1990 end-page: 464 article-title: Mast cells as a source of multifunctional cytokines publication-title: Immunology Today contributor: fullname: Galli SJ – volume: 53 start-page: 457 year: 1958 end-page: 486 article-title: Nonparametric estimation from incomplete observation publication-title: J Am Stat Assoc contributor: fullname: Meier P – volume: 18 start-page: 703 year: 1976 end-page: 709 article-title: Mast cells and tumor angiogenesis publication-title: Int J Cancer contributor: fullname: Folkman J – volume: 79 start-page: 185 year: 1965 end-page: 191 article-title: Role of mast cells in tumor growth publication-title: Arch Pathol contributor: fullname: Fisher B – volume: 89 start-page: 335 year: 1988 end-page: 340 article-title: Immunoreactivity of normal and neoplastic human tissue mast cells publication-title: Am J Clin Pathol contributor: fullname: Kaiserling E – volume: 4 start-page: 146 year: 1984 end-page: 146 article-title: Mast cell changes and tumour dissemination in human breast carcinoma publication-title: Invasion & Metastasis contributor: fullname: Maartmann-Moe H – volume: 34 start-page: 187 year: 1972 end-page: 220 article-title: Regression models and life-tables publication-title: J R Stat Soc B contributor: fullname: Cox DR – volume: 119 start-page: 57 year: 1985 end-page: 64 article-title: Mast cells and tumors. The specific enhancement of tumor proliferation in vitro publication-title: Am J Pathol contributor: fullname: Roche WR – volume: 69 start-page: 1305 year: 1982 end-page: 1309 article-title: Evidence for involvement of mast cells in tumor suppression in mice publication-title: J Natl Cancer Inst contributor: fullname: Kondo S – volume: 365 start-page: 340 year: 1993 end-page: 343 article-title: Induction of human IgE synthesis in B cells by mast cells and basophils publication-title: Nature contributor: fullname: Bonnefoy JY – volume: 134 start-page: 7 year: 1981 end-page: 7 article-title: Mast cells and metachromasia in human breast cancer: Their occurrence, significance and consequences: A preliminary report publication-title: J Pathol contributor: fullname: Hartveit F – volume: 41 start-page: 1 year: 1991 end-page: 9 article-title: Biological properties of human skin mast cells publication-title: Clin Exp Allergy contributor: fullname: Okayama Y – volume: 164 start-page: 119 year: 1990 end-page: 146 article-title: Immunohistochemical identification of mast cells in formaldehyde-fixed tissue using monoclonal antibodies specific for tryptase publication-title: J Pathol contributor: fullname: Holgate ST – volume: 3 start-page: 166 year: 1879 end-page: 169 article-title: Beitrage zur Kenntniss der granulirten Bindegewebszellen und der eosinophilen leukocythen publication-title: Arch Anat Physiol contributor: fullname: Ehrlich P – volume: 96 start-page: 857 year: 1991 end-page: 863 article-title: Extracellular localization of human connective tissue mast cell granule contents publication-title: Invest Dermatol contributor: fullname: Murphy GF – volume: 152 start-page: 931 year: 1980 end-page: 931 article-title: Mast cell heparin stimulates migration of capillary endothelial cells in vitro publication-title: J Exp Med contributor: fullname: Folkman J – volume: 153 start-page: 520 year: 1981 end-page: 533 article-title: Mast cell-mediated tumor-cell cytotoxicity: Role of the peroxidase system publication-title: J Exp Med contributor: fullname: Klebanoff SJ – volume: 148 start-page: 17 year: 1986 end-page: 184 article-title: The nature and significance of tumorassociated mast cells publication-title: J Pathol contributor: fullname: Roche WR – ident: atypb3 doi: 10.1093/ajcp/89.3.335 – ident: atypb6 doi: 10.1084/jem.152.4.931 – ident: atypb8 doi: 10.1038/365340a0 – ident: atypb43 doi: 10.1111/1523-1747.ep12475169 – ident: atypb4 doi: 10.1111/j.1365-2222.1991.tb01757.x – ident: atypb19 doi: 10.1084/jem.153.3.520 – volume: 2 start-page: 204 year: 1989 ident: atypb10 publication-title: Neurofibromatosis contributor: fullname: Ionov ID – volume: 79 start-page: 185 year: 1965 ident: atypb17 publication-title: Arch Pathol contributor: fullname: Fisher ER – ident: atypb30 doi: 10.1172/JCI114344 – ident: atypb31 doi: 10.1016/0006-291X(84)90470-4 – ident: atypb14 doi: 10.1038/bjc.1961.41 – ident: atypb26 doi: 10.1002/path.1711480208 – ident: atypb7 doi: 10.1038/293103a0 – volume: 4 start-page: 146 year: 1984 ident: atypb22 publication-title: Invasion & Metastasis contributor: fullname: Hartveit F – ident: atypb24 doi: 10.1080/09553009114552021 – ident: atypb41 doi: 10.1002/path.1711620204 – volume: 188 start-page: 61 year: 1994 ident: atypb33 publication-title: Relation to type and gr.de of malignancy. Pathol Res Pract contributor: fullname: Donhuijsen K – ident: atypb40 doi: 10.1002/path.1711340103 – volume: 34 start-page: 187 year: 1972 ident: atypb38 publication-title: J R Stat Soc B doi: 10.1111/j.2517-6161.1972.tb00899.x contributor: fullname: Cox DR – volume: 464 start-page: 671 year: 1989 ident: atypb5 publication-title: JAMA contributor: fullname: Claman HN – start-page: 17 volume-title: Farbenanalytische Untersuchungen year: 1891 ident: atypb11 contributor: fullname: Westphal E – volume-title: A treatise on tumors year: 1928 ident: atypb15 contributor: fullname: Ewing J – volume: 119 start-page: 57 year: 1985 ident: atypb25 publication-title: Am J Pathol contributor: fullname: Roche WR – volume: 64 start-page: 4416 year: 1988 ident: atypb12 publication-title: Cancer contributor: fullname: Ueda T – ident: atypb21 doi: 10.1016/0008-8749(80)90162-8 – ident: atypb35 doi: 10.1002/1097-0142(197710)40:4<1562::AID-CNCR2820400428>3.0.CO;2-6 – volume: 69 start-page: 1305 year: 1982 ident: atypb16 publication-title: J Natl Cancer Inst contributor: fullname: Tanooka H – volume-title: Pathologic basis of disease year: 1994 ident: atypb1 contributor: fullname: Cotran RS – volume: 3 start-page: 166 year: 1879 ident: atypb9 publication-title: Arch Anat Physiol contributor: fullname: Ehrlich P – ident: atypb37 doi: 10.1080/01621459.1958.10501452 – volume: 74 start-page: 671 year: 1985 ident: atypb20 publication-title: J Natl Cancer Inst contributor: fullname: Burtin C – ident: atypb42 doi: 10.1164/ajrccm/142.4.863 – volume: 7 start-page: 686 year: 1947 ident: atypb32 publication-title: Cancer Res contributor: fullname: Holgren H – ident: atypb39 doi: 10.1002/ijc.2910420110 – volume: 123 start-page: 3 year: 1966 ident: atypb18 publication-title: Surg Gynecol Obstet contributor: fullname: Graham RM – ident: atypb27 doi: 10.1002/ijc.2910180520 – volume-title: Soft tissue tumors year: 1994 ident: atypb34 contributor: fullname: Enzinger FM – ident: atypb36 doi: 10.1002/1097-0142(19840201)53:3<530::AID-CNCR2820530327>3.0.CO;2-D – ident: atypb13 doi: 10.1016/S0344-0338(85)80184-9 – ident: atypb29 doi: 10.1007/BF00119080 – ident: atypb2 doi: 10.1016/0167-5699(90)90176-A – ident: atypb23 doi: 10.1038/bjc.1991.192 – volume: 59 start-page: 1 year: 1945 ident: atypb28 publication-title: Acta Radiol contributor: fullname: Sylven B |
| SSID | ssj0002621 |
| Score | 1.5258113 |
| Snippet | Mast cells (MC) are known to play an important role in IgE-dependent allergic reaction, host defense against parasite infestation, local hemostasis,... |
| SourceID | proquest crossref sage |
| SourceType | Aggregation Database Publisher |
| StartPage | 141 |
| Title | The Prognostic Significance of Mast Cell Count in Soft Tissue Sarcomas |
| URI | https://journals.sagepub.com/doi/full/10.1177/106689699900700303 https://www.proquest.com/docview/214187005 https://search.proquest.com/docview/21195490 |
| Volume | 7 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED-cgvgifuL8zIMPggS7Nm2aJ1HZGIJDZMLeRpoP8MFWbf3_veuyTRF9bZqG3v1yd0l-uQM4T7RFP55F3EgXc5ELzbWXjlO2p9wkibWeNvQfRtnwWdxP0kng5tSBVjm3ia2htpWhPfKruCd6iK0ovX5751Q0ig5XQwWNDqxRMwJ87bY_enxamOI4m128Qr_Kc5Wp-a2Z9r55ltEjtMaIeoR68tMzLcPNbwyv1ukMtmAzRIvsZqbebVhx5Q6sP4Tz8F0YoJYZUazKivItM2JjEPeHVMkqz1513TDam2dtTQj2UrIa7S5rWnGzGlFO_KA9GA_647shD5URuImVaLiIpfSul-jY6UgXhU_z3CdOZL6IfO7TFFcVyqaRxtUE-WSMy4xJE2sSnTqcxPuwWlalOwCmRCaswTVLLnOhCqWVsNIV0pvIKvxyFy7nQpm-zfJfTHshRfhvEXbhaC63aZgL9XShuS6cLVoRxPT3unTVJ71CiedU1IULEvay799DHf471BFszPIrEK_2GFabj093gtFDU5xCR07kaUDKFyHLvz0 |
| link.rule.ids | 315,786,790,12083,21416,27955,27956,31752,31753,33777,33778,43343,43838,74100,74657 |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3JTsMwEB1BkYALYhWlLD5wQEIWaewsPiGEqMpSTkXqLXK8SBxICkn_n5k0LSAE12xWZp5nsZ9nAM6FtujH44CbxIVcplJz7RPHqdpTaoSw1tOC_ug5Hr7Ih0k0abk5VUurXNjExlDb0tAa-VXYl33EVhBdT985NY2izdW2g8YqrEkhJME8mSzzLcwu5seu0KvyVMVqcWamOW0ex3QJbTFiHoEufvqlr2DzG7-rcTmDbdhqY0V2M1fuDqy4YhfWR-1u-B4MUMeMCFZFSdWWGXExiPlDimSlZ2-6qhmtzLOmIwR7LViFVpfVjbBZhRgndtA-jAd349shb_sicBMqWXMZJol3faFDpwOd5z5KUy-cjH0e-NRHEeYUykaBxlyCPDJGZcZEwhqhI4dT-AA6RVm4Q2BKxtIazFjSJJUqV1pJm7g88SawCr_chcuFULLpvPpF1m8LhP8WYRd6C7ll7UyosqXeunC2vIsQpr_XhStn9AiVnVNBFy5I2F_v_j3U0b9DncHGcDx6yp7unx97sDmvtEAM22Po1B8zd4JxRJ2fNmj5BGpav90 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3JTsMwEB1BkRAXxCrKVh84ICGLNHEWnxACqrK04gBSb5HjReJAAiT9f2ZSt4AQXLNZmRnPYj-_ATiJlME4ngRcpzbkIhOKK5daTmxPmY4iYxwt6I_GyfBZ3E3iiacUqj2scu4TW0dtKk1r5OdhX_TRtoL43HlUxOP14OLtnVMDKdpo9d00lmEFg2RAXRzSyaL2wkpjdgQLIyzPZCLn52fak-dJQpfQL6P9o9FHP2PUV-L5DevVhp_BBqz7vJFdzhS9CUu23ILVkd8Z34YB6psR2KqsiHmZES6DUECkVFY59qrqhtEqPWu7Q7CXktXogVnTCp7VaO-EFNqBp8HN09WQ-x4JXIdSNFyEaepsP1KhVYEqChdnmYusSFwRuMzFMdYX0sSBwrqCojNmaFrHkdGRii1O513olFVp94BJkQijsXrJ0kzIQiopTGqL1OnASPxyF87mQsnfZkwYed-Thf8WYRcO5nLL_ayo84UOu9Bb3EVzpr9Xpa2m9AhR0MmgC6ck7K93_x5q_9-herCKhpI_3I7vD2BtRrpAYNtD6DQfU3uEKUVTHLfG8gl9dsQJ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+prognostic+significance+of+mast+cell+count+in+soft+tissue+sarcomas&rft.jtitle=International+journal+of+surgical+pathology&rft.au=Zhang%2C+Paul+J&rft.au=Kobos%2C+Jozef+W&rft.au=Brooks%2C+John+J&rft.date=1999-07-01&rft.pub=SAGE+PUBLICATIONS%2C+INC&rft.issn=1066-8969&rft.eissn=1940-2465&rft.volume=7&rft.issue=3&rft.spage=141&rft_id=info:doi/10.1177%2F106689699900700303&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=48771670 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1066-8969&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1066-8969&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1066-8969&client=summon |