The Prognostic Significance of Mast Cell Count in Soft Tissue Sarcomas
Mast cells (MC) are known to play an important role in IgE-dependent allergic reaction, host defense against parasite infestation, local hemostasis, inflammation, and angiogenesis. The significance of MC in tumor surveillance has been studied with conflicting results. The presence of MC in tumor has...
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Published in | International journal of surgical pathology Vol. 7; no. 3; pp. 141 - 148 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Thousand Oaks, CA
SAGE Publications
01.07.1999
SAGE PUBLICATIONS, INC |
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Abstract | Mast cells (MC) are known to play an important role in IgE-dependent allergic reaction, host defense against parasite infestation, local hemostasis, inflammation, and angiogenesis. The significance of MC in tumor surveillance has been studied with conflicting results. The presence of MC in tumor has been described as evidence of a host immunologic antitumor response, and a high count of tumor-associated MC has been considered as a favorable prognostic factor in sarcomas. In other studies, MC have been shown to have an adverse role in neoplastic proliferation. In this study, tumor-associated MC were histologically quantitated in 75 soft tissue sarcomas. We found that soft tissue sarcomas with a higher MC count (n=or>six) were associated with significant better survival and relatively low incidence of metastasis in contrast to those with a lower count (n<six). There was no correlation between MC count and the histologic type, grade, or size of the sarcomas. Although the role of mast cells in tumor surveillance is still under investigation, quantitive assessment of tumorassociated MC on routine histologic sections could be used as an additional prognostic factor in soft tissue sarcomas. |
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AbstractList | Mast cells (MC) are known to play an important role in IgE-dependent allergic reaction, host defense against parasite infestation, local hemostasis, inflammation, and angiogenesis. The significance of MC in tumor surveillance has been studied with conflicting results. The presence of MC in tumor has been described as evidence of a host immunologic antitumor response, and a high count of tumor-associated MC has been considered as a favorable prognostic factor in sarcomas. In other studies, MC have been shown to have an adverse role in neoplastic proliferation. In this study, tumor-associated MC were histologically quantitated in 75 soft tissue sarcomas. We found that soft tissue sarcomas with a higher MC count (n=or>six) were associated with significant better survival and relatively low incidence of metastasis in contrast to those with a lower count (n<six). There was no correlation between MC count and the histologic type, grade, or size of the sarcomas. Although the role of mast cells in tumor surveillance is still under investigation, quantitive assessment of tumorassociated MC on routine histologic sections could be used as an additional prognostic factor in soft tissue sarcomas. |
Author | Zhang, Paul J. Kobos, Jozef W. Brooks, John J. |
Author_xml | – sequence: 1 givenname: Paul J. surname: Zhang fullname: Zhang, Paul J. organization: Division of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY – sequence: 2 givenname: Jozef W. surname: Kobos fullname: Kobos, Jozef W. organization: Medical University of LodY, Poland – sequence: 3 givenname: John J. surname: Brooks fullname: Brooks, John J. organization: Division of Pathology & Laboratory Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263 |
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Cites_doi | 10.1093/ajcp/89.3.335 10.1084/jem.152.4.931 10.1038/365340a0 10.1111/1523-1747.ep12475169 10.1111/j.1365-2222.1991.tb01757.x 10.1084/jem.153.3.520 10.1172/JCI114344 10.1016/0006-291X(84)90470-4 10.1038/bjc.1961.41 10.1002/path.1711480208 10.1038/293103a0 10.1080/09553009114552021 10.1002/path.1711620204 10.1002/path.1711340103 10.1111/j.2517-6161.1972.tb00899.x 10.1016/0008-8749(80)90162-8 10.1002/1097-0142(197710)40:4<1562::AID-CNCR2820400428>3.0.CO;2-6 10.1080/01621459.1958.10501452 10.1164/ajrccm/142.4.863 10.1002/ijc.2910420110 10.1002/ijc.2910180520 10.1002/1097-0142(19840201)53:3<530::AID-CNCR2820530327>3.0.CO;2-D 10.1016/S0344-0338(85)80184-9 10.1007/BF00119080 10.1016/0167-5699(90)90176-A 10.1038/bjc.1991.192 |
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Copyright | Copyright Westminster Publications, Inc. Jul 1999 |
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Keywords | mast cell count sarcoma Giemsa stain prognosis |
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Title | The Prognostic Significance of Mast Cell Count in Soft Tissue Sarcomas |
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