Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation

• Published in: The Journal of immunology (1950) Vol. 180; no. 4; pp. 2669 - 2678
• Main Authors: Kanamaru, Yutaka, Pfirsch, Séverine, Aloulou, Meryem, Vrtovsnik, François, Essig, Marie, Loirat, Chantal, Deschênes, Georges, Guérin-Marchand, Claudine, Blank, Ulrich, Monteiro, Renato C
• Format: Journal Article
• Language: English
• Published: United States 15.02.2008
• Subjects: Amino Acid Motifs - immunology; Animals; Antigens, CD - physiology; Cell Line, Tumor; Cell Migration Inhibition - immunology; Cell Movement - immunology; Cells, Cultured; Glomerulonephritis, IGA - immunology; Glomerulonephritis, IGA - metabolism; Glomerulonephritis, IGA - pathology; Glomerulonephritis, IGA - prevention & control; Humans; Kidney - immunology; Kidney - pathology; Leukocytes - immunology; Leukocytes - metabolism; Leukocytes - pathology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Myeloid Cells - immunology; Myeloid Cells - metabolism; Myeloid Cells - pathology; Rats; Receptors, Fc - physiology; Receptors, IgG - physiology; Receptors, Immunologic - physiology; Signal Transduction - immunology

Inhibitory signaling is an emerging function of ITAM-bearing immunoreceptors in the maintenance of homeostasis. Monovalent targeting of the IgA Fc receptor (FcalphaRI or CD89) by anti-FcalphaRI Fab triggers potent inhibitory ITAM (ITAM(i)) signaling through the associated FcRgamma chain (FcalphaRI-F...