Low density lipoprotein receptor deficiency in cultured hepatocytes of the WHHL rabbit. Further evidence of two pathways for catabolism of exogenous proteins

• Published in: The Journal of biological chemistry Vol. 256; no. 19; pp. 9789 - 9792
• Main Authors: Attie, A D, Pittman, R C, Watanabe, Y, Steinberg, D
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 10.10.1981
• Subjects: Animals; Cells, Cultured; Chloroquine - pharmacology; Colchicine - pharmacology; Female; Hydroxymethylglutaryl CoA Reductases - metabolism; Hyperlipidemias - genetics; Hyperlipidemias - metabolism; Kinetics; Lipoproteins, LDL - metabolism; Lipoproteins, LDL - pharmacology; Liver - drug effects; Liver - metabolism; Rabbits; Receptors, Cell Surface - metabolism; Receptors, LDL

We have studied hepatocytes cultured from Watanabe-heritable hyperlipidemic (WHHL) rabbits, animals that display striking elevation of plasma low density lipoprotein (LDL), spontaneous atherosclerosis, and an absence of LDL receptor activity in cultured fibroblasts. Degradation of LDL by WHHL hepato...