CSF Aβ42 predicts early-onset dementia in Parkinson disease

• Published in: Neurology Vol. 82; no. 20; p. 1784
• Main Authors: Alves, Guido, Lange, Johannes, Blennow, Kaj, Zetterberg, Henrik, Andreasson, Ulf, Førland, Marthe G, Tysnes, Ole-Bjørn, Larsen, Jan P, Pedersen, Kenn F
• Format: Journal Article
• Language: English
• Published: United States 20.05.2014
• Subjects: Aged; Amyloid beta-Peptides - cerebrospinal fluid; Dementia - cerebrospinal fluid; Dementia - complications; Dementia - diagnosis; Female; Humans; Male; Middle Aged; Parkinson Disease - cerebrospinal fluid; Parkinson Disease - complications; Peptide Fragments - cerebrospinal fluid; Prognosis; Risk

To test in vivo the proposal from clinicopathologic studies that β-amyloid (Aβ) pathology shortens the time to dementia in Parkinson disease (PD), and to explore the utility of CSF Aβ and related measures as early prognostic biomarkers of dementia in an incident PD cohort. We assessed a population-b...