Effect of Rifampicin on The Pharmacokinetics of Selexipag, An Oral Prostacyclin Receptor Agonist, and Its Active Metabolite In Healthy Male Subjects

• Published in: Clinical therapeutics Vol. 39; no. 8; p. e24
• Main Authors: Bruderer, S., Petersen-Sylla, M., Boehler, M., Remeňová, T., Halabi, A., Dingemanse, J.
• Format: Journal Article
• Language: English
• Published: Bridgewater Elsevier Inc 01.08.2017; Elsevier Limited
• Subjects: Internal Medicine; Medical Education; Pharmacokinetics; Prostacyclin; Rifampin

Methods This was an open-label, randomized, two-treatment, two-period, crossover study including 20 healthy male subjects. Concomitant administration of selexipag and multiple-dose rifampicin led to no relevant change in exposure to selexipag (geometric mean ratios [Treatment B/Treatment A] and 90%...