Effect of Rifampicin on The Pharmacokinetics of Selexipag, An Oral Prostacyclin Receptor Agonist, and Its Active Metabolite In Healthy Male Subjects
Methods This was an open-label, randomized, two-treatment, two-period, crossover study including 20 healthy male subjects. Concomitant administration of selexipag and multiple-dose rifampicin led to no relevant change in exposure to selexipag (geometric mean ratios [Treatment B/Treatment A] and 90%...
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| Published in | Clinical therapeutics Vol. 39; no. 8; p. e24 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Bridgewater
Elsevier Inc
01.08.2017
Elsevier Limited |
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| Online Access | Get full text |
| ISSN | 0149-2918 1879-114X |
| DOI | 10.1016/j.clinthera.2017.05.073 |
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| Abstract | Methods This was an open-label, randomized, two-treatment, two-period, crossover study including 20 healthy male subjects. Concomitant administration of selexipag and multiple-dose rifampicin led to no relevant change in exposure to selexipag (geometric mean ratios [Treatment B/Treatment A] and 90% confidence intervals [CIs] for maximum plasma concentration (Cmax) and area under... |
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| AbstractList | Methods This was an open-label, randomized, two-treatment, two-period, crossover study including 20 healthy male subjects. Concomitant administration of selexipag and multiple-dose rifampicin led to no relevant change in exposure to selexipag (geometric mean ratios [Treatment B/Treatment A] and 90% confidence intervals [CIs] for maximum plasma concentration (Cmax) and area under... |
| Author | Dingemanse, J. Bruderer, S. Boehler, M. Remeňová, T. Petersen-Sylla, M. Halabi, A. |
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| DOI | 10.1016/j.clinthera.2017.05.073 |
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| Snippet | Methods This was an open-label, randomized, two-treatment, two-period, crossover study including 20 healthy male subjects. Concomitant administration of... |
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| Title | Effect of Rifampicin on The Pharmacokinetics of Selexipag, An Oral Prostacyclin Receptor Agonist, and Its Active Metabolite In Healthy Male Subjects |
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