Hypomethylation at PANDAR promoter progressively induces senescence in adipocyte precursor cells in subjects with obesity and type 2 diabetes

• Published in: The FASEB journal Vol. 38; no. 19; pp. e70093 - n/a
• Main Authors: Desiderio, Antonella, Pastorino, Monica, Campitelli, Michele, Prevenzano, Immacolata, De Palma, Fatima Domenica Elisa, Spinelli, Rosa, Parrillo, Luca, Longo, Michele, Milone, Marco, Miele, Claudia, Raciti, Gregory Alexander, Beguinot, Francesco
• Format: Journal Article
• Language: English
• Published: United States 15.10.2024
• Subjects: Adipocytes - metabolism; adipose precursor cells; Adult; cellular senescence; Cellular Senescence - genetics; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; DNA Methylation; Female; Humans; lncRNA; Male; Middle Aged; obesity; Obesity - genetics; Obesity - metabolism; PANDAR; Promoter Regions, Genetic; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; type 2 diabetes; adipose precursor cells; cellular senescence; lncRNA; type 2 diabetes; PANDAR; DNA methylation; obesity

The risk of developing type 2 diabetes (T2D) is heterogeneous among individuals with obesity. Functional decline of adipocyte precursor cells (APCs) and accumulation of senescent cells in the subcutaneous adipose tissue contributes to the progression toward T2D. LncRNAs regulate cell senescence and...